NewSr. Principal Technical Program Manager, INT Digital ModernaTXSr. Principal Technical Program Manager, INT DigitalCambridge, MassachusettsOwn portfolio-level financial and resource planning, including labor forecasts, actuals, resource assumptions, spend, and investment tradeoffs, making owner-minded decisions that keep technology investment aligned with priorities, expected outcomes, and the cost-efficient delivery of INT. Lead the planning and delivery of the INT Digital portfolio, translating business and technology strategy into a clear roadmap, executable plans, milestones, dependencies, and measurable outcomes across mINT products and offshore delivery teams.
NewPrincipal Research Associate, Clinical Biomarker Laboratory ModernaTXPrincipal Research Associate, Clinical Biomarker LaboratoryNorwood, MassachusettsParticipate in review of protocols, methods, reports, batch records and related GLP/GcLP source documents to actively manage data and documents by using various software like Excel, LabVantage LIMS (Laboratory Information Management System) database for clinical phase studies. The Principal Research Associate will work closely with the clinical Biomarker Laboratory Lead, biostatisticians, Quality/ Compliance partners, and other cross-functional stakeholders to deliver high-quality, traceable, and regulatory-compliant bioanalytical data supporting Vaccine clinical development programs.
Principal Scientist (Director), Translational Medicine - Cardiovascular Merck & Co IncPrincipal Scientist (Director), Translational Medicine - CardiovascularBoston, MA$260,300–$409,700 / yearInterface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late-stage Clinical Research throughout research sites around the world. Contributing to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into the earliest stages of target identification and validation, and executing clinical studies to evaluate the relevance of potential targets to human disease in order to justify investment in clinical development programs.
Principal Product Manager - Billing Duck Creek Technologies LLCPrincipal Product Manager - BillingBoston, MAFor reference, the expected salary range for this position is generally positioned as follows based on candidate location: 171,900 - 245,500: Candidates living in the Boston, New York City-Newark, Los Angeles, San Francisco/Bay Area, Seattle, or Washington, DC metropolitan areas. Experience delivering configurable, transaction-centric platforms, including rules-driven and AI-enabled or model-informed workflows, and translating customer needs, regulatory constraints, financial controls, and analytical outputs into governed product decisions.
Principal Scientist, Translational Clinical Biomarkers Merck & Co IncPrincipal Scientist, Translational Clinical BiomarkersBoston, MA$190,800–$300,300 / yearFor cardiovascular and metabolic programs, develop biomarker strategies addressing areas such as target engagement, pathway modulation, disease biology, pharmacodynamic response, patient heterogeneity, and relationships between biological effects and clinical outcomes. The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity, dose and regimen selection, clinical endpoints, and opportunities for precision medicine.
NewPrincipal Engineer (AI, Office of the CEO) JobberPrincipal Engineer (AI, Office of the CEO)Boston, MassachusettsEmbed with teams across the company, working day-to-day with function leaders and their teams and weekly with executive leadership, shipping AI into real workflows and leaving behind systems and owners that outlast the visit. Reporting to the VP of Customer Experience Innovation , the Principal Software Engineer will be the founding technical seat: you'll architect and build new AI systems from zero to production, and own the hard problems that come with putting AI at the center of how a company runs — trust, permissions, security, and quality at scale.
Principal Embedded Software Engineer Lexington Medical, Inc.Principal Embedded Software EngineerBedford, MA$180,000–$220,000 / yearDesign, build, and integrate real-time embedded software for Lexington Medical's surgical stapling platform and supporting devices, primarily using ARM Cortex-M or equivalent microcontroller-based systems. With engineering, manufacturing, and quality working closely together, engineers stay close to the product and see their work move from an idea through prototyping, testing, manufacturing, and ultimately into the operating room.
NewPrincipal Research Associate, Analytical Development ModernaTXPrincipal Research Associate, Analytical DevelopmentNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Moderna is seeking a Principal Research Associate to serve as a critical bridge for development, method transfer, and routine operations between Analytical Development (AD) and cross-functional partners including Analytical Sciences & Technology (AST), Quality Control (QC), Analytical Technical Operations (ATO), and Quality Assurance (QA).
NewPrincipal Engineer (Ai, Office Of The Ceo) JobberPrincipal Engineer (Ai, Office Of The Ceo)Boston, MAThe role: Reporting to the VP of Customer Experience Innovation, the Principal Software Engineer will be the founding technical seat: you'll architect and build new AI systems from zero to production, and own the hard problems that come with putting AI at the center of how a company runs - trust, permissions, security, and quality at scale. Embed with teams across the company, working day-to-day with function leaders and their teams and weekly with executive leadership, shipping AI into real workflows and leaving behind systems and owners that outlast the visit.
Principal Scientist (Director), Translational Medicine - Infectious Diseases Merck & Co IncPrincipal Scientist (Director), Translational Medicine - Infectious DiseasesBoston, MA$260,300–$409,700 / yearPrimary responsibilities for the Principal Scientist include the following: Working with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets, including the design of preclinical and clinical experiments to validate targets and/or pathways, and leveraging this work for development of novel therapeutics. Translational Medicine is specifically responsible for: Contributing to the identification of novel targets by partnering with Discovery Sciences to bring a clinical perspective into the earliest stages of target identification and validation, and to execute clinical studies to evaluate the relevance of potential targets to human disease in order to justify full development.
NewPrincipal Scientist, Pharmacokinetics, Biologics Merck & Co IncPrincipal Scientist, Pharmacokinetics, BiologicsBoston, MA$176,200–$277,300 / yearIn this exciting position, your primary roles will include: Lead bioanalytical strategies for a portfolio of drug discovery programs with a primary focus on biologics (monoclonal antibodies, bispecifics, and engineered proteins), providing high quality and timely data to project teams across our Research & Development Division's drug discovery portfolio. Required Skills: ADME, Bioanalysis, Bioanalytical Method Development, Biologics, Cross-Functional Teamwork, Drug Development, Drug Discovery Research, Drug Metabolism, Ligand Binding, Pharmaceutical Sciences, Pharmaceutics, Pharmacodynamics, Pharmacokinetics, Pharmacology, PKPD Modeling, Therapeutic Proteins.
Principal Controls and Automation Engineer Michael Page InternationalPrincipal Controls and Automation EngineerBillerica, Massachusetts$180,000–$200,000 / yearFull timeBachelor's degree in Electrical Engineering, Controls Engineering, Automation Engineering, or a related technical discipline. The organization is driving innovation in energy storage manufacturing through proprietary technologies that improve efficiency, scalability, and sustainability.
Principal Controls and Automation Engineer - Tewksbury, MA Michael Page InternationalPrincipal Controls and Automation Engineer - Tewksbury, MATewksbury, MA$180,000–$200,000 / yearFull timeThe culture encourages innovation, cross-functional teamwork, and professional development, making it an excellent opportunity for individuals who thrive on solving complex technical challenges and leading transformative projects. This organization offers a collaborative environment where engineering leaders are empowered to drive change, introduce new ideas, and make a measurable impact.
BAS Principal - Valuation, Financial Forensics, Litigation (VFL) LitmanGerson AssociatesBAS Principal - Valuation, Financial Forensics, Litigation (VFL)Woburn, MA$140,000–$230,000 / yearFull timespecializing in a given subset Education and Experience:Bachelor's degree in Accountancy, Marketing, Finance, or a related fieldMaster's degree in Accountancy, Marketing, Finance or a plan to pursue preferredOne or more of the following credentials: certified public accountant (CPA), certified valuation analyst (CVA), accredited in business valuation (ABV), chartered financial analyst (CFA), certified business appraiser (CBA), accredited senior appraiser (ASA), certified divorce financial analyst (CDFA) CPA, CVA, ABV, CBA, or ASA certification is required 10+ years' of recent experience in a related field, with a proven ability to lead and develop client relationships. Acts as the firm's preeminent resource in specific technical areasProvides advice and council to clients, partners, and staffManages client expectations, develop solutions, and champions the implementation of client needs and ideasConsistently meets client deadlines timely and adheres to delivering specific client scopesIdentifies and recommends additional services that would be beneficial to clientsProvides exceptional customer service, ensuring client understands services, processes, etc.
Principal Software Engineer-SRE PTC IncPrincipal Software Engineer-SREBoston, MA$131,000–$200,000 / yearToday, we are a global team of nearly 7,000 and our main objective is to create opportunities for our team members to explore, learn, and grow - all while seeing their ideas come to life and celebrating the differences that make us who we are and the work we do possible. Onshape's Site Reliability Engineering team is looking for a Principal Software Engineer to play a critical role in ensuring the long‑term reliability, scalability, and operational excellence of our platform.
Principal Systems Analyst Onto Innovation IncPrincipal Systems AnalystWilmington, MAOnto Innovation is a leader in process control, combining global scale with an expanded portfolio of leading-edge technologies that include: 3D metrology spanning the chip from nanometer-scale transistors to micron-level die-interconnects; macro defect inspection of wafers and packages; metal interconnect composition; factory analytics; and lithography for advanced semiconductor packaging. You'll also enjoy access to our Employee Stock Purchase Program (ESPP), wellness initiatives, and cutting-edge tools-all within a collaborative, inclusive culture where your contributions are valued and recognized.
Sr. Principal Scientist, Nonclinical Drug Safety Merck & Co IncSr. Principal Scientist, Nonclinical Drug SafetyBoston, MA$190,800–$300,300 / yearStrategically influence nonclinical drug safety considerations for Immunology programs by providing drug development mentorship and partnering with Compound Leaders on time-critical matters, including nonclinical program design and toxicology study design, weight-of-evidence risk assessments, science-based waiver strategies, and integrated safety development plans that support clinical trials, global registration, and timely resolution of nonclinical development issues. Provide scientific and strategic oversight for Immunology candidates through close collaboration with Program Coordinators, Discovery Preclinical Leaders, Compound Leaders, and scientists across NDS and/or Preclinical Development, while ensuring strong partnership with key Research and Development Division functions, including Discovery, chemistry, regulatory affairs, translational medicine, clinical development, and CMC.
Principal, Fund Controller Partner's CapitalPrincipal, Fund ControllerBoston, Massachusetts$120,000–$170,000 / yearStrategic Partnership and Other: You will serve as a trusted advisor to global client CIOs, fund PMs, and research teams, ensuring fund finance considerations are integrated into broader strategic decisions. The Firm designs bespoke investment policies reflecting each client’s unique circumstances and implements investment solutions that aim to deliver strong returns with resilience across market cycles.
Principal Scientist (Scientific Director Level)- Nonclinical Drug Safety Merck & Co IncPrincipal Scientist (Scientific Director Level)- Nonclinical Drug SafetyBoston, MA$176,200–$277,300 / yearThey are responsible for 1) providing risk assessments for targets, 2) de-risking strategies for discovery programs and 3) collaborating with NDS staff at other sites to execute on the appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates. The Discovery Program Leader is responsible for defining and overseeing the NDS strategy for programs in all modalities (including small molecules, peptides, biologics and ADC programs) from Target Identification through to the approval of First-In-Human enabling GLP toxicity studies.
Principal Systems Verification Architect (IST, North Reading, MA) Teradyne IncPrincipal Systems Verification Architect (IST, North Reading, MA)North Reading, MA$166,300–$266,100 / yearTeradynes Integrated Systems Test (IST) Hardware Engineering team is seeking a highly motivated, energetic and technically driven Senior Systems Engineer to deliver world-class System-Level Test solutions to a growing portfolio of customers. Multidisciplinary technical expertise in one or more of the following: complex electronic systems, network systems, embedded systems, automation and controls, thermal systems, power distribution, pneumatics, software usability or test execution.