NewProgram Manager, Principal - Secret DCS CorporationProgram Manager, Principal - SecretBedford, MA$123,639–$199,000 / yearIn this Advisory and Assistance Services (A&AS) role, you will provide expert-level support to Department of Defense (DoD) programs by assisting government leadership with decision-making, planning, and execution throughout the acquisition lifecycle. DCS has an exciting opportunity for a Program Manager SME (Principal) supporting the Air Force Life Cycle Management Center/PEO Electronic Systems Directorate (AFLCMC/HB) within the HBU Force Protection Division at Hanscom AFB.
Cyber Defense Principal Engineer Spyglass Partners, LLCCyber Defense Principal EngineerHybrid/Onsite, MASpyglass Partners LLC has over 20 years of experience as a nationwide staffing firm and is your ideal source for all your project-based temporary and direct-hire staffing needs. Spyglass Partners excels in placing contract and direct-hire resources across all aspects of IT, Accounting & Finance, Sales, and Executive roles.
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development 3316 Takeda Development Center AmericasSenior/Principal Scientist, Analytical Cell Line Engineering and Bioassay DevelopmentLexington, Massachusetts$154,400–$242,550 / yearHow you will contribute: Lead the design, generation, characterization, and lifecycle management of stable mammalian analytical cell lines expressing targets of interest, receptor systems, or reporter constructs to support potency and functional bioassays. Operating at the interface between Discovery, Global Biologics, Analytical Development, and late-stage potency teams, this role translates product mechanism of action into scientifically sound, phase-appropriate cell line and assay strategies.
Principal Noise Consultant AcentechPrincipal Noise ConsultantCambridge, MA$115,000–$145,000 / yearAcentech, a multidisciplinary design consulting firm specializing in acoustics, vibration, audiovisual systems, IT and security system design seeks to hire a senior- to principal-level consultant to work with our Noise and Vibration team. We foster a collaborative environment of diverse talent, and encourage people of color, lesbian, gay, bisexual, transgender, queer and non-binary people, neurodivergent, veterans, parents, and individuals with disabilities to apply.
Principal Engineer, Core Infrastructure KlaviyoPrincipal Engineer, Core InfrastructureBoston, MA$248,000–$372,000 / yearIn addition to base salary, our total compensation package may include participation in the company’s annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑enabled platform: Approved AI tooling is integrated into IDE/CI/CD with repo policies and auditability; 70% MAU among eligible engineers; MTTR down 20–30% via AI‑assisted triage; flaky‑test rate decreases through targeted, AI‑suggested fixes.
Principal Program Scheduler Torch TechnologiesPrincipal Program SchedulerHanscom AFB, Massachusetts$145,000–$160,000 / yearBy enabling aircrews to electronically receive and process tasking orders, intelligence inputs, target coordinates, and mission‑critical flight and weapons data, MPS enhances combat effectiveness, increases sortie generation rates, and improves aircrew readiness and survivability across the Combat Air Forces (CAF) and Mobility Air Forces (MAF). Several factors can influence the salary for a position including but not limited to, Federal Government contract labor categories and contract wage rates, geographic location, business considerations, scope and responsibilities of the position, local or other applicable market conditions, and internal equity.
Principal Scientist, TCR Optimization ModernaTXPrincipal Scientist, TCR OptimizationCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. The role is well suited for a hands-on scientist who can execute complex experimental workflows, interpret multi-parameter datasets, and contribute to the generation of optimized TCR candidates with the potency, specificity, and developability required for therapeutic advancement.
Principal Scientist, Antibody Discovery and Engineering ModernaTXPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MassachusettsThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Software Engineer Boston Human Capital PartnersPrincipal Software EngineerBoston, MassachusettsRemoteThis role centers on building high-performance distributed systems, powering data-intensive services, and enabling seamless, secure integrations across modern IT and security ecosystems. only) and best suited for engineers who excel in fast-moving startup environments where autonomy, rapid iteration, and strong technical judgment are essential.
Principal AI/ML Researcher WhoopPrincipal AI/ML ResearcherBoston, MassachusettsDeep expertise in modern deep learning (transformers, state space models), multimodal training, self-supervised and representation learning, RL-based post-training (PPO/DPO/GRPO), and large-scale distributed training (data, model, and context parallelism). At WHOOP, we view total compensation as the combination of base salary, equity, and benefits, with equity serving as a key differentiator that aligns our employees with the long-term success of the company and allows every member of our corporate team to own part of WHOOP and share in the company’s long-term growth and success.
Principal RA Associate Devices Fresenius Medical CarePrincipal RA Associate DevicesWaltham, MassachusettsResponsible for preparing FDA submissions necessary for new product approvals/clearances which include Premarket norifictoins-510(k)s, Premarket Approval Applications (PMAs) and supplements, Investigational Device Exemptions (IDEs) submissions. Serves as the primary regulatory resource for change to and prioritization of projects, resource assignment and efficient management of the development and change processes.
Principal Engineer, Data Infrastructure KlaviyoPrincipal Engineer, Data InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company’s annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑augmented data operations: Semantic discovery and auto‑documentation cover the majority of high‑value datasets; AI‑assisted DQ monitors reduce data incidents on top pipelines by 25–40%; pipeline authoring and review times drop 15–25% with AI in the loop.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Principal Software Engineer, Platform Engineering ModernaTXPrincipal Software Engineer, Platform EngineeringCambridge, MassachusettsThis is a senior individual contributor role that combines deep technical execution with cross-functional technical leadership across developers ("Builders"), Cybersecurity, Architecture, AI platform teams, and broader teams to provide scalable, secure, and user-focused capabilities that make the right path the easiest path for Moderna’s engineering teams. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MassachusettsThe Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level. Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal Product Designer MoonpigPrincipal Product DesignerManchester, NHWe’re proud to have a number of employee-led groups driving this forward, including our LGBTQ+, Gender Balance, Neurodiversity and EMBRACE (Educating Myself for Better Racial Awareness and Cultural Enrichment) communities, plus our Group-wide EDI committee. Wellbeing First: Private healthcare (UK) and mental health support ️ Flexible Working & Time Off: Generous holidays, hybrid working (1-3 days in office, depending on role/team) & up to 20 days of international working.
Mergers & Acquisition, Lead Transaction Principal TeradyneMergers & Acquisition, Lead Transaction PrincipalNorth Reading, MA$219,900–$351,900 / yearTeradyne is a global leader in automated test equipment and industrial automation, enabling customers across the semiconductor, electronics, and advanced manufacturing ecosystem to accelerate innovation and deliver high-quality products at scale. Across semiconductor test, system-level and wafer-level test, photonics, and adjacent semiconductor capital equipment, Teradyne operates at the intersection of deep engineering, complex supply chains, and long investment cycles.
Principal Systems Engineer, Digital Lab Systems ModernaTXPrincipal Systems Engineer, Digital Lab SystemsNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team.
NewPrincipal SDET – Linux Kernel Premier Global LinksPrincipal SDET – Linux KernelCambridge, MassachusettsPremier Global Links LLC is seeking an experienced Principal Software Development Engineer in Test SDET to lead test strategy, automation, and system-level validation for a highly distributed, Linux-based AI and compute platform. This is a senior technical leadership opportunity for an engineer who enjoys working at the Linux kernel level, solving complex infrastructure problems, and building scalable automated testing and continuous integration systems.