Staff/Principal DevOps Engineer, AI Inference Lila SciencesStaff/Principal DevOps Engineer, AI InferenceCambridge, Massachusetts$192,000–$272,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. This role bridges platform engineering, site reliability, and ML infrastructure, building the systems that power low-latency, high-throughput inference across GPU clusters and cloud accelerators.
Principal Engineer, AI Security Lila SciencesPrincipal Engineer, AI SecurityCambridge, Massachusetts$255,000–$348,000 / yearMulti-Layer AI Security (Network, Endpoint, Data) — Integrate AI security into existing enterprise security layers: network visibility and control over AI service access, API traffic inspection, and zero trust enforcement; endpoint security for developer machines, research environments, browsers, and plugins; data layer controls ensuring proper handling of sensitive data when interacting with AI systems. While Lila builds AI-powered systems, this role is primarily focused on securing the use of third-party and internally deployed AI tools across the enterprise — ensuring sensitive data, intellectual property, and scientific workflows are protected as AI becomes deeply embedded in how work gets done.
Principal Cybersecurity Engineer Avenue Technologies CompanyPrincipal Cybersecurity EngineerMarlborough, MassachusettsAvenue Technologies is seeking a Principal Cybersecurity Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate with engineering and program teams to maintain secure and compliant systems.
Principal SoC Architect - Hardware NVIDIAPrincipal SoC Architect - HardwareWestford, MassachusettsYou have meaningful industry expertise in SoC architecture definition - Clocks, Resets, Automotive safety, Interconnects, Memory Controller, Boot, Virtualization, Power Management, Security, System Performance, IO technologies, (PCIE, Camera Interfaces, etc), Multimedia accelerator pipelines, CPU/GPU coherency, Platform integration. In this position, you will have the chance to define future aspects of our architectures that bring together NVIDIA GPUs, custom processors and accelerators into a single chip.
Principal Manufacturing Engineer-NPI TransMedicsPrincipal Manufacturing Engineer-NPIAndover, MassachusettsPOSITION SUMMARY: The Principal Engineer – NPI Manufacturing serve as the technical project leader for NPI manufacturing activities, driving the development and commercialization of TransMedics perfusion set and OCS products. To accomplish this mission, we partner closely with transplant stakeholders worldwide and help expand their access to healthy donor organs, while delivering the highest quality technology, service, clinical care and outcomes.
Principal Associate I, Plant Quality Assurance - 2ND SHIFT ReplimunePrincipal Associate I, Plant Quality Assurance - 2ND SHIFTFramingham, Massachusetts$120,000–$155,000 / yearThe Principal Associate I/II, Plant Quality Assurance (PQA) reports to the Associate Director, Quality Assurance and is responsible for on-going Quality oversight to ensure real time quality oversight for Drug Substance, Drug Product, and all other production and QC testing activities according to current good manufacturing practices (cGMP), good documentation practices (GDP) and other applicable regulations. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Principal Mechanical Engineer Berkshire Grey Inc.Principal Mechanical EngineerBedford, MAThe candidate must be highly experienced and autonomous with respect to designing, fabricating, and testing new designs, as well as launching new products into production and supporting systems fielded at customer sites. Significant experience designing systems that are used in industrial settings, expecting to balance cost and durability for maximum customer success over the capital equipment's full depreciation lifespan.
Principal Modeling And Simulation Engineer Berkshire Grey Inc.Principal Modeling And Simulation EngineerBedford, MAIn the role of Principal Modeling and Simulation Engineer, you will lead the development of high-fidelity simulation platforms and digital twins that drive system design, validation, and deployment. This role blends advanced software engineering with modeling and simulation, enabling rapid development, testing, and optimization of complex robotic systems.
Principal Consultant - Life Sciences LumanityPrincipal Consultant - Life SciencesBoston, MassachusettsAs a trusted advisor to senior leaders across the life sciences industry, you will lead complex consulting engagements, cultivate long-term client relationships, identify new business opportunities, and mentor high-performing consulting teams. As a global strategic partner that brings together strategy, evidence, engagement, and technology, we were designed to engineer breakthrough value to tackle our clients’ toughest challenges by revolutionizing how value is generated, demonstrated, and communicated.
Associate Principal Threat Intelligence Analyst Rockstar GamesAssociate Principal Threat Intelligence AnalystAndover, MA$125,000–$150,000 / yearIf hired, employee will be in an "at-will position" and the company reserves the right to modify base salary (as well as any other discretionary payment or compensation or benefit program) at any time, including for reasons related to individual performance, company or individual department/team performance, and market factors. Become part of a team working on some of the most rewarding, large-scale creative projects to be found in any entertainment medium - all within an inclusive, highly-motivated environment where you can learn and collaborate with some of the most talented people in the industry.
Principal Systems Management Analyst - Epic Healthy Planet UnitedHealth Group Inc.Principal Systems Management Analyst - Epic Healthy PlanetAuburndale, MA$112,700–$193,200 / yearAs a Principal Systems Management Analyst focusing on Epic Healthy Planet and Epic Cheers, you will partner with clinical, operational, and technical leadership to drive population health strategies and patient engagement workflows. Evaluate current-state workflows and identify opportunities to optimize Healthy Planet functionality to improve care gap closure, patient outreach, quality performance, and provider efficiency.
Principal Systems Engineer - CLEARANCE REQUIRED BelcanPrincipal Systems Engineer - CLEARANCE REQUIREDTewksbury, MAACTIVE US Secret Clearance REQUIREDDesired Skill Sets:* Experience using test equipment, software installations, and integrating or regression testing systems with certifications in CompTIA Network+ and or CompTIA Security+.* Experience with MATLAB, Linux Operating Systems (Linux Red Hat), Unix, Perl, C/C++, and Shell scripting for performing integration, verification and test analysis, integrating and configuring electronics/network routers, and installing/debugging software.* Experience with agile and DevSecOps processes, implement (or maintain) agile methodologies, participating in daily team standup meetings, sprint reviews, program Increment (PI) Planning meetings, retrospectives, and agile tooling such as JIRA and Confluence, and support execution of the team"s backlog including performance analysis and issue investigation.*
Principal Systems Engineer – Quantum Computing Systems QuEra ComputingPrincipal Systems Engineer – Quantum Computing SystemsBoston, MassachusettsThe ideal candidate brings extensive experience building complex hardware–software systems (e.g., aerospace, EVs, robotics, advanced instrumentation) and is motivated to apply systems engineering rigor in a learning-driven R&D environment , pairing closely with internal quantum experts. We are seeking a Principal Systems Engineer to play a critical role in aligning engineering execution with scientific and machine-level progress in the development of large-scale quantum computers.
Client Service Principal, Taxable Partners Capital Investment Group LLPClient Service Principal, TaxableBoston, MA$115,000–$160,000 / yearPart timeProactively identify and mitigate potential risks related to client accounts, working internally to identify, assess, and mitigate risks associated with client accounts and operational processes. Hands-on experience servicing US taxable clients (HNW families and family offices), including multi-entity household structures, tax-aware investment operations, and coordination with external CPAs and trust & estate counsel.
Principal Electrical Engineer RE Build Manufacturing, LLCPrincipal Electrical EngineerWilmington, MA$165,000–$250,000 / yearAn experienced engineering leader with a broad range of electrical engineering disciplines, including analog and digital circuit design, power electronics, PCB design, sensors, instrumentation, embedded electronics, and electromechanical systems. We operate an advanced, end-to-end manufacturing platform that partners with industrial companies and innovators to take products from first concept to full-scale production in critical verticals including aerospace and defense, electrification, medical, energy and environment, and robotics and automation.
NewPrincipal AI Program Manager, Appeals Innovation And Automation - Remote UnitedHealth Group Inc.Principal AI Program Manager, Appeals Innovation And Automation - RemoteBoston, MARemote$91,700–$163,700 / yearThis role serves as the bridge between business operations, clinical leadership, technology teams, legal, compliance, privacy, security, and enterprise governance to ensure the responsible deployment of AI capabilities that improve quality, efficiency, consistency, and user experience. The ideal candidate will possess deep expertise in AI agents, workflow automation, generative AI, and healthcare operations, with a proven ability to translate business challenges into AI-enabled solutions.
NewPrincipal Data Engineering - Remote - CST UnitedHealth Group Inc.Principal Data Engineering - Remote - CSTBoston, MARemote$112,700–$193,200 / yearDeploy AI and Data-Driven Solutions: Develop and deploy large-scale data pipelines empowering machine learning algorithms, insights generation, business intelligence dashboards, reporting, and new data products while utilizing enterprise-approved AI tools to address complex business challenges. Working with advanced platforms such as Azure Databricks, Snowflake, and LLMs, you will build data solutions that empower machine learning, insights generation, and business automation, directly contributing to better clinical and administrative connectivity across the healthcare system.
NewPrincipal Software Engineer, Semantic Data Services WEX Inc.Principal Software Engineer, Semantic Data ServicesBoston, MA$200,600–$250,400 / year10+ years of experience in software engineering, data engineering, distributed systems, data platforms, or related technology areas, with demonstrated experience operating at Staff, Principal, or equivalent technical scope. Experience with technologies such as Spark, Flink, Kafka, Iceberg, Snowflake, Databricks, cloud-native data services, graph databases, or equivalent large-scale data technologies.
NewPrincipal Engineer, Process Development Sarepta Therapeutics Inc.Principal Engineer, Process DevelopmentBedford, MA$136,000–$170,000 / yearThe ideal candidate will bring deep experience in complex biologics or bioconjugate manufacturing, hands-on analytical capability such as HPLC, strong knowledge of cGMP and CMC expectations, and the communication and cross-functional leadership skills needed to advance programs from development through late-stage clinical or commercial production. Technical background in AOC, antibody-drug conjugates, bioconjugates, oligonucleotide therapeutics, Fab/antibody intermediates, AAV vectors, viral vector manufacturing, or other complex biologics is strongly preferred.
Principal MRB Engineer BelcanPrincipal MRB EngineerLynn, MA$104,000–$145,600 / yearA Principal MRB Engineer is needed to support the needs and goals of manufacturing teams with engineering substantiation reviews to determine the acceptability of aircraft engine hardware. Mentor and develop Junior Engineers who perform analysis to document acceptability of parts to include stresscalculations, tolerance stack ups, and leveraging of previous analysis.*