46 Results for

Principal Jobs in San Diego, CA

Jobs

New!

San Diego, CA2 days ago

$170,000–$225,000 Per Year

Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. We are seeking a Principal Solutions Architect – Machine Learning to serve as a trusted advisor to clients while leading the design and delivery of enterprise AI / ML solutions.

San Diego, California7 days ago

Remote

$255,000–$300,000 Per Year

We provide a broad range of strategic, financial, operational, and technology-enabled consulting services to the full continuum of care, including hospitals, health systems, medical groups, academic medical centers, children’s hospitals, cancer centers, ambulatory surgery centers, investors, and payers/health plans. As part of a dyad leadership model, you will partner with another ECG principal with deep expertise in academic healthcare, including medical schools and health sciences centers, and a proven track record in growing consulting practices to advance the MSAG business and foster a culture of continuous quality improvement.

San Diego, CA12 days ago

$264,000–$330,000 Per Year

At its core, Realm-X is built on a structured domain ontology and a set of shared business primitives—such as transactions, actions, reports, metrics, and skills—that enable AI systems to deeply understand and operate across the full context of property management workflows. It enables a new generation of intelligent capabilities across our products, including Realm-X Assistant (copilot), Flows (AI Agentic workflows) and Performers (autonomous AI Agents).

San Diego, CA30+ days ago

Full-time

Partner with Neuroscience Discovery on the evaluation of target opportunities from the perspective of cutting-edge genetics, bioinformatics, biosignatures, brain biology, and mechanism, drawing upon a combination of internal and external human data resources and integrative analytics. We are searching for a Senior Principal Scientist, Computational Multiomics, Precision Measures, to be in either Cambridge, MA; Spring House, PA; La Jolla, CA United States of America or Beerse, Antwerp, Belgium, and follows a hybrid schedule of three days in the office and two days remotely per week.

Chula Vista, CA30+ days ago

Perform stress analysis and develop analytical methods for complex technical issues requiring creativity and ingenuity in creating product repairs and allowable damage limits to support engine manufacturers and airframers. Our global team is committed to continuous improvement – we work hard to make our solutions lighter-weight, stronger and more technically advanced, so that plane travel can be safer, more affordable and more sustainable in the years to come.

San Diego, CA30+ days ago

$150,000–$200,000

Responsible for project execution per internally and customer defined processes, reaching, documenting and defending project milestones: requirement, design and test readiness reviews, integration and test events, test reports, installation and support activities. Expert in a subset of technical areas: systems engineering, optics and photonics, AMO physics, control theory, opto-mechanics, electrical and software engineering.

San Diego, CA30+ days ago

$160,000–$240,000

San Diego, CA24 days ago

Full-time

Hands-on algorithm and model development: Design, prototype, and implement AI/ML methods for genomics and multiomics (e.g., basecalling, variant calling, error modeling, QC, anomaly detection, methylation, single-cell, metagenomics, assembly, interpretation). The Principal Deep Learning/AI Engineer Bioinformatics is a senior hands-on technical expert responsible for inventing, implementing, and validating AI- and ML-driven bioinformatics methods that directly power Illumina's sequencing and analysis products.

San Diego, CA30+ days ago

As a trusted partner, we provide actionable solutions and innovation through our Aerospace Technologies, Building Automation, Energy and Sustainability Solutions, and Industrial Automation business segments – powered by our Honeywell Forge software – that help make the world smarter, safer and more sustainable. We are a leading software-industrial company committed to introducing state-of-the-art technology solutions to improve efficiency, productivity, sustainability, and safety in high-growth businesses in broad-based, attractive industrial end markets.

San Diego, CA30+ days ago

Full-time

We’ve listed a broad salary range of $150,000-$200,000/year to account for varying levels of experience, skill sets, and leadership depth. Guide and mentor Brand Managers to elevate team performance and outcomes as well as manage cross-functional teams to execute brand and advertising initiatives.

San Diego, CA30+ days ago

Full-time

We’ve listed a broad salary range of $125,000-$175,000/year to account for varying levels of experience, skill sets, and leadership depth. We’re looking for a Principal Advertising Strategist to join our powerhouse team and lead strategy for enterprise clients across Amazon and other retail media platforms.

New!

San Diego, CA5 days ago

Full-time

We've listed a broad salary range of $175,000-$220,000/year to account for varying levels of experience, depth in cloud warehouse architecture, and leadership scope. Design scalable frameworks for normalizing complex marketplace data (orders, fees, ad metrics, settlements, inventory events) into analysis-ready schemas.

San Diego, CA30+ days ago

$150,000–$200,000

You will collaborate closely with device, optical, electrical, mechanical, and manufacturing engineers to transform delicate photonic designs into robust, manufacturable, high-yield products. 5+ years with demonstrated ownership of manufacturing process equipment such as die bonders, wire bonders, vacuum reflow systems, active alignment platforms, or laser welding systems.

San Diego, CA15 days ago

$150,000–$190,000

This role will be a critical member of a talented team of engineers that demonstrate superb technical competency, delivering mission critical communications systems and ensuring the highest levels of availability, performance, and security. This role will support the agile development of innovative communications, networking, and computing solutions for U.S. defense agencies that improve the sharing of information among warfighters distributed throughout airborne, maritime, and ground environments.

San Diego, CA30+ days ago

$165,000–$225,000

Demonstrated successful execution of engineering tasks including use of mechanical CAD and quantitative analysis/programming tools, instrumentation and measurement, part fabrication or procurement, integration and test, data collection, analysis and documentation. Use tenacity, patience, self-discipline and passion for excellence to assure accuracy of execution schedule, data quality/integrity, conformance to company best practices, clarity in communication and documentation.

San Diego, CA30+ days ago

$170,000–$240,000

You'll have the opportunity to work on cutting edge technologies, work closely with leadership, and develop and implement engineering practices that support our mission and growth. PhD in Physics, Electrical Engineering, Optical Engineering, or related field (exceptional MS candidates considered).

San Diego, CA30+ days ago

$150,000–$200,000

You’ll work closely with device, optical, mechanical, and manufacturing engineers to turn fragile photonic designs into robust, repeatable products. Experience: BS or MS in Optical Engineering, Electrical Engineering, Materials Science, Mechanical Engineering, Physics, or related field.

San Diego, CA30+ days ago

$160,000–$240,000

Define and guide the development of core photonics and control technologies, including laser stabilization, narrow linewidth sources, and low-noise electronic control systems. Your key responsibilities are as follows: Provide technical leadership and system-level direction on the architecture, design, and integration of advanced laser systems for quantum technologies.

San Diego, CA30+ days ago

$190,000–$235,000

Lead complex engineering programs from concept through production, including requirements definition, architecture development, risk assessment, and cross‑functional alignment. This position is ideal for a highly experienced engineer who thrives in ambiguity, leads with initiative, and elevates the technical bar for the entire organization.

San Diego, CA30+ days ago

$175,000–$225,000

You will work closely with device, optical, mechanical, and manufacturing engineers to turn fragile photonic designs into reliable, manufacturable products—with particular ownership over fiber-based processes and interfaces. Join our fast-paced and passionate team as a Principal Photonics Process Development Engineer with deep expertise in optical fiber processes.

San Diego, CA7 days ago

$175,000–$240,000

Drive end-to-end ownership from concept, modeling, and design through tapeout, validation, and production release\Architect innovative solutions balancing noise, linearity, power consumption, and silicon area for high-performance applications. As a Principal Engineer in Analog Design at Elevate Semiconductor, you will operate at the highest level of technical leadership while remaining deeply hands-on in architecture and circuit design.

San Diego, CA30+ days ago

If you are keen to work with a bunch of brilliant people with various backgrounds, if you share the same value of working smart and celebrating successes, if you have enthusiasm for big technology in a small company, if your goals are to learn and experience different aspects of work--not just singing the same song every day, you'll find your playground at Innophase IoT. As a Physical Design Principal Engineer, you will be responsible for the entire SOC implementation and verification flow from RTL-to-GDS that includes floorplan, place and route, CTS, STA, PV/EMIR/Noise/SigEM cleanup and signoff on lower power SoC.

San Diego, CA30+ days ago

Full-time

We serve a broad base of private-sector, municipal, and public agency clients and frequently collaborate with Rincon’s other practice areas—including Environmental/Community Planning, Natural Resources, Cultural Resources, Marine Services, and Sustainability and Climate Action—to pursue and execute high-profile, multidisciplinary projects. Our EES team is composed of geologists, hydrogeologists, and environmental engineers, planners, and scientists who deliver services spanning environmental due diligence, site assessment and remediation, watershed sciences, water resources, and environmental construction compliance and management.

San Diego, CA16 days ago

Technical experience will include the following: Ability to perform conceptual and preliminary engineering design studies (incorporating land use and zoning considerations, assessment and consideration of site constraints, infrastructure requirements, and potential regulatory issues). Possesses working knowledge of business and management principles associated with strategic planning, resource allocation, leadership techniques, production procedures, interview and hiring methods and the coordination of people.

San Diego, California16 days ago

Financial & Business Case Leadership: Lead the development of robust business cases, clearly defining ROI, cost-benefit analysis, and financial impact to prioritize initiatives and secure funding. As a premier individual contributor, this leader will partner directly with executive stakeholders to align the strategic roadmap, applying rigorous critical path thinking to prioritize high-impact initiatives and accelerate value.

New!

San Diego, California5 days ago

Maintain awareness of, and effectively communicate across the organization, applicable information related to changes in business environment, marketing needs/opportunities, competitor landscape, service delivery requirements, technical challenges, and potential new sales and/or existing account opportunities. The Principal Surveyor-in-Charge leads and manages the direct, daily survey/operations for a specific location (i.e., port, station, country, shipyard, client site, etc.) in alignment with ABS Operating Principles and Mission.

San Diego, California30+ days ago

$103,400–$171,000 Per Year

Licenses and/or exams necessary for this position include: Resident state Life/Health and Variable Annuity license; non-resident state Life/Health and Variable Annuity licensing for all non-resident states in which business will be conducted. Posting Window: We will accept applications for 3 full days following the Original Posting Date, after which the posting may remain open or be removed based upon applications received.

San Diego, CA30+ days ago

$204,000–$284,000 Per Year

Reverse engineering complex software or firmware targets, ranging from typical Windows/Linux binaries to embedded firmware running non-traditional computer architectures and operating systems. Offers are based on factors, such as but not limited to, the candidate's experience, education, training, key skills/critical skills, security clearances, and prevailing market and business conditions.

San Diego, CA29 days ago

$140,400–$213,900 Per Year

Strategic thinker with the ability to build and present robust product demos, combined with the communication skills needed to develop customer relationships by listening to, understanding, and anticipating client needs (business and IT). As a key contributor to the Pega Sales Consulting team, you will collaborate with product managers, software developers, analysts, business officers, and other groups to ensure the successful execution of sales strategy.

New!

San Diego, California2 days ago

$195,000–$215,000 Per Year

San Diego, CA30+ days ago

$155,000–$170,000 Per Year

Deep Discovery & Molecular Tooling Context - 7 + years with relevant advanced degree building/ s uppor ting platforms and tools , for c omputational compound d esign and protein engineering workflows (Schrodinger, Open E ye , MOE, Mi XCR , Alphafold ) ; fluent in SAR analysis , sequence/structure predictions , and assay lifecycles. + GenAI engineering depth - Demonstrated success building GenAI Applications and agentic workflows ; fine-tuning and deploying LLMs, diffusion models, structure-prediction models (AlphaFold family, RoseTTAFold ), or vision transformers for scientific or operational use-cases.

San Diego, CA30+ days ago

$125,000–$160,000 Per Year

This leadership role involves overseeing the planning, design, and delivery of private and public land development projects, managing project teams, and coordinating with agencies and clients. We are looking for an experienced Principal Civil Engineer to lead land development projects in the San Diego, area.

San Diego, CA30+ days ago

$195,700–$342,500 Per Year

In this hands-on, highly technical leadership role, you will be a key driver in scaling our Flow Engine, orchestration framework, and automation intelligence stack to support complex, AI-native enterprise workloads. + Lead the architecture, design, and evolution of our core backend and workflow engine frameworks, ensuring they are highly scalable, performant, and resilient across millions of transactions and automation flows.

San Diego, CA30+ days ago

Mentor and Scale Field Teams: Act as a thought leader within the organization, mentoring Solutions Consultants and Forward Deployed Engineers and helping to evolve and refine our AI solution delivery best practices. • Influence Product and GTM Strategy: Collaborate closely with product and engineering teams to relay field insights, identify gaps in our prebuilt agent inventory, and influence the product roadmap based on strategic customer needs.

Poway, CA30+ days ago

$160,000–$180,000 Per Year

Continuous Improvement: Take the initiative to research, develop, propose, evaluate and/or implement new methods, processes, techniques, tools, components, or technology that improve quality, timeliness and/or performance of products or the efficiency or cost effectiveness of engineering work. Responsibilities: Product Specifications: Implement innovative approaches and develop clearly written design specifications that ensure our products are designed to succeed in the market relative to their technical performance, feature set, cost and time to market goals.

San Diego, CA30+ days ago

$120,000–$170,000 Per Year

Provide Clinical Pharmacology and pharmacometrics leadership for designated programs, contribute to design of clinical trial protocols and relevant sections in Investigational Brochure (IB), conduct hands-on analysis of clinical or translational PKPD data, support dosing strategies and clinical pharmacology planning. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

San Diego, California30+ days ago

$125,000–$169,000 Per Year

Job Summary: Negotiates favorable terms, volume discounts and long-term contracts with suppliers and prepares and processes requisitions and purchase orders for the procurement of goods, services and supplies for customer-related business processes or for internal use as a generalist or in a combination of Purchasing Disciplines Impact of the Role: General Profile. Company Overview: General Dynamics Ordnance and Tactical Systems (OTS) is a global leader in the design, engineering and production of munitions, energetics, weapons, armaments, and missile subsystems around the world.

San Diego, CA30+ days ago

$150,000–$200,000

San Diego, CA23 days ago

$175,000–$250,000 Per Year

The Principal Environmental Engineer will serve as the senior technical authority for environmental engineering tasks across the business line, providing executive leadership and strategic direction in the characterization and remediation of complex environmental projects. APTIM Federal Services, LLC is committed to providing an extensive range of benefits that protect and promote the health and financial well-being of our employees and their families through the APTIM Benefits Marketplace https://aptim.makeityoursource.com/ .

San Diego, CA24 days ago

Remote

Part-time

Maximus compensation is based on various factors including but not limited to job location, a candidate's education, training, experience, expected quality and quantity of work, required travel (if any), external market and internal value analysis including seniority and merit systems, as well as internal pay alignment. - Lead the development, evolution, and maintenance of a real-time or near-real-time core enterprise data set that Maximus employees and leadership consume and contribute to daily-ensuring it is complete, correct, relevant, timely, and actionable.

New!

San Diego, California6 days ago

Remote

Experience with Federal permitting programs such as the Clean Water Act, the Clean Air Act, the US Army Corps of Engineers (USACE) 404 wetland permitting, the US Fish & Wildlife Service or the US National Marine Fisheries Sections 7 and 10 consultations, and the National Historic Preservation Act for Section 106 consultations. Assist in the development and planning of new and modified facilities, as well as providing integrated consulting, environmental, design and construction support for some of the largest projects in the U.S. Manage projects and staff, including providing technical leadership and oversight, risk management, and mentoring.

New!

San Diego, CA1 day ago

Extensive knowledge of at least two of the following domains: o Offensive Security / Penetration Testingo SIEM and Security Data Lakeso Cloud Security (CNAPP, CSPM)o Endpoint Detection and Responseo Network Detection and Responseo Vulnerability Managemento Application Securityo Threat Exposure Managemento Continuous Controls Monitoring. This role requires a seasoned product professional with extensive experience across cybersecurity defensive and governance offerings, along with a strong understanding of evolving industry use cases and the impact of AI on the cybersecurity landscape.

San Diego, CA30+ days ago

By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. For example, Debugging Azure Networking for Elastic Cloud Serverless is part of our efforts, and we want your experience to contribute to a truly exceptional customer experience.

San Diego, California21 days ago

Baker Tilly Advisory Group, LP and Baker Tilly US, LLP, trading as Baker Tilly, are independent members of Baker Tilly International, a worldwide network of independent accounting and business advisory firms in 141 territories, with 43,000 professionals and a combined worldwide revenue of $5.2 billion. Baker Tilly is a leading advisory, tax and assurance firm, providing clients with a genuine coast-to-coast and global advantage in major regions of the U.S. and in many of the world's leading financial centers - New York, London, San Francisco, Los Angeles, Chicago and Boston.

San Diego, California19 days ago

$166,900–$248,265 Per Year

SRI is organized around broad disciplines and capabilities, with research and development divisions and labs to groups who excel at identifying new opportunities, developing products, and creating custom solutions. Is a thought leader with a proven track record of significant research contributions and delivery of solutions in the areas that include innovative remote sensing technologies.

San Diego, CA26 days ago

Remote

Full-time

Maximus compensation is based on various factors including but not limited to job location, a candidate's education, training, experience, expected quality and quantity of work, required travel (if any), external market and internal value analysis including seniority and merit systems, as well as internal pay alignment. - Define and enforce test strategies for data migrations, including unit testing, data reconciliation testing, performance testing, and business validation.

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Principal Jobs in San Diego, CA

Jobs

Principal Solutions Architect – Machine LearningJobot

Principal, Physician Educator LeadECG Management Consultants

Principal Machine Learning EngineerAppFolio, Inc

Senior Principal Scientist, Computational Multiomics, Precision MeasuresJohnson and Johnson

Principal Stress Engineer (Onsite)RTX Corporation

Principal Project Engineer, Photonic System DevelopmentMonarch Quantum

Senior Principal Project Engineer, Photonic System DevelopmentMonarch Quantum

Principal Deep Learning/AI Engineer, BioinformaticsIllumina, Inc.

Principal Account Manager – Maritime BusinessHoneywell

Principal Brand Manager (Amazon Marketplace)Luminize

Principal Advertising Strategist (Amazon Marketplace)Luminize

Principal Data ArchitectLuminize

Principal Photonics Process Development Engineer Packaging and ToolingMonarch Quantum

Principal Mechanical EngineerFuse Integration

Senior Principal Robotics Process EngineerMonarch Quantum

Principal Laser Scientist New Laser DevelopmentMonarch Quantum

Principal Photonics Process Development EngineerMonarch Quantum

Senior Principal Quantum Photonics Systems EngineerMonarch Quantum

Principal Electrical Engineer 5Monarch Quantum

Principal Photonics Process Development Engineer - Fiber Process FocusMonarch Quantum

Principal Analog Design EngineerElevate Semiconductor

Principal Engineer, Physical DesignInnoPhase IoT

Director/ Principal of Business DevelopmentRincon Consultants, Inc

Principal Project EngineerATALNT LLC

Sr. Principal, Solutions ManagementCotality

Principal Surveyor In Charge or above - San DiegoAmerican Bureau of Shipping (ABS)

Managing Director - Principal Financial Network (San Diego)Principal Financial Group

Principal Software Reverse EngineerSTR

Principal Solutions ConsultantPegasystems

Principal Engineer – Water, Wastewater & Recycled WaterDudek

Principal AI Engineer (GenAI) - Molecular DiscoveryBristol Myers Squibb

Principal Civil Engineer – Land DevelopmentPTS Advance

Principal Software EngineerServiceNow, Inc.

Principal AI Field ArchitectBoomi

Principal Embedded Software EngineerCaltek Staffing

Senior Scientist / Principal Scientist, Clinical PharmacologyArrowhead Pharmaceuticals

Procurement PrincipalGeneral Dynamics Ordnance & Tactical Systems

Principal Robotics Process EngineerMonarch Quantum

Principal Environmental EngineerAPTIM

Senior Principal Enterprise ArchitectMaximus

Principal Practice Leader - Air QualityGeosyntec Consultants, Inc.

Principal Product ManagerDeep Seas

Principal Software Engineer (Networking) - PlatformElastic

Risk Advisory Services PrincipalBaker Tilly Advisory Group, LP

Sr Principal Research EngineerSRI International

IT Principal Data Architect - ( Data Migration )Maximus

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