Principal Data Scientist Gradient AIPrincipal Data ScientistBoston, MARemoteDeep experience being accountable for model impact long term – from MLOps pipelines to monitor for drift, to KPI and impact monitoring, driving incremental and long-term improvements, triaging issues, addressing tech debt responsibly, etc. Our platform harnesses a vast industry data lake – tens of millions of policies and claims enriched with economic, health, geographic, and demographic signals – integrating cleanly with existing workflows to make complex risk clear, usable, and actionable.
Senior Principal Scientist Waters CorpSenior Principal ScientistMilford, MAIn addition to leading innovation in material design, you will help advance next-generation manufacturing strategies for Waters particle and bonded-phase production, including scalable and data-rich manufacturing approaches, advanced process characterization, and in-process analytical testing methodologies. As a Senior Principal Scientist within the BioSeparations Portfolio of the Chemistry & Lab Automation Business Unit, you will define and lead the scientific strategy for novel chromatographic materials and enabling chemistries for biologics ranging from oligonucleotides, viral vectors, and mRNA to proteins, peptides, and gene-editing therapeutics.
Principal Software Developer - SafeTrace Haemonetics CorpPrincipal Software Developer - SafeTraceBoston, MA$103,600–$176,400 / yearWe are seeking a Principal Software Developer to drive the technical direction of SafeTrace Tx, our industry-leading transfusion management software trusted by hundreds of hospitals to deliver complete testing and transfusion histories in a single, consolidated patient record. As a principal-level contributor, you will lead the design of scalable integrations with hospital information systems such as Epic, applying service-oriented and event-driven architecture principles to ensure reliable, real-time communication from the blood bank to the bedside.
Principal DevOps Architect Harvard Business PublishingPrincipal DevOps ArchitectBoston, MA$160,000–$175,000 / yearAs a key member of the Technology Operations leadership team, you will define and lead our DevOps strategy-partnering closely with engineering, cloud operations, and security to deliver secure, reliable, and scalable platforms. Partner with software engineering and product teams to translate delivery needs into an efficient CI/CD ecosystem-recommending, selecting, implementing, evolving, and optimizing tools and practices.
Principal Scientist, Agentic Systems for Pipeline Strategy Flagship Pioneering IncPrincipal Scientist, Agentic Systems for Pipeline StrategyCambridge, MA$179,000–$236,000 / yearThis role will serve as PI''s in-house expert in clinical and commercial strategy, and will lead the codification of therapeutic pipeline strategy as agentic capabilities: translating the judgment that today lives in the heads of senior strategic and translational leaders into autonomous systems that identify, evaluate, and prioritize opportunities to create new medicines at a level of scale and rigor that humans alone cannot achieve. Own the "legitimate patient need" problem end-to-end: define what it means for an agentic tool to identify and value a real, underserved patient need, what a product that addresses it looks like, and build the evaluations, ground-truth sets, and feedback loops that make agent outputs trustworthy enough to inform pipeline decisions.
Principal Scientist, Computational Protein Design Moderna IncPrincipal Scientist, Computational Protein DesignCambridge, MA$142,500–$256,500 / yearWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna's Research and Early Development portfolio.
Principal Scientist, Machine Learning Flagship Pioneering, Inc.Principal Scientist, Machine LearningCambridge, MA USA$208,000–$286,000 / yearBreadth across domains such as genomics, protein modeling/design, proteomics/mass spec, multi-omics, cheminformatics/docking/ADMET, biophysics/MD, and scientific literature mining, with the ability to connect them using LLM-based agents and agentic workflows. We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects that accelerate pharmaceutical R&D across the preclinical, translational, and clinical continuum, working closely with Pioneering Medicines (PM) and across Flagship’s platform companies as part of the company origination process.
Principal Solutions Architect Maven AGI IncPrincipal Solutions ArchitectBoston, MAYou will own pre-SOW technical validation, design production-grade AI agent architectures, guide Forward Deployed Engineers from POC through launch, and help convert field learnings into reusable platform capabilities. 7+ years in Solutions Architecture, Applied Engineering, Forward Deployed Engineering, Sales Engineering, or equivalent customer-facing technical leadership for enterprise SaaS, data, ML, or AI products.
Principal Product Manager, AI Infrastructure and Orchestration DataRobot IncPrincipal Product Manager, AI Infrastructure and OrchestrationBoston, MAIt does not own agent coordination and authoring (planner and router logic, memory strategy, multi-agent handoff, builder surfaces), workflow orchestration in the Airflow or Temporal sense, model quality and applied research, or cluster fabric work such as InfiniBand and RoCE tuning for distributed training. Deep technical understanding of GPU and accelerator behavior: topology-aware placement, fractional and time-sliced sharing, MIG, device plugins and the driver and container runtime plumbing underneath them, memory as the binding constraint, and what utilization costs when a tenant holds a GPU it is not saturating.
Principal Scientist, Antibody Discovery and Engineering Moderna IncPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MA$142,500–$256,500 / yearThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
NewPrincipal IT Security Project Manager BullhornPrincipal IT Security Project ManagerMassachusettsProgram Leadership: Direct large-scale cross-functional security projects, such as large scale software hardening, identity management rollouts, cloud security implementations, or zero-trust implementations. A Principal IT Security Project Manager leads complex, enterprise-wide cybersecurity initiatives and manages strategic security programs from planning to completion.
Principal Signal Processing Engineer - Cardiac Ablation Solutions MedtronicPrincipal Signal Processing Engineer - Cardiac Ablation SolutionsNewton, MassachusettsIf you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. The following benefits and additional compensation are available to those regular employees who work 20+ hours per week: Health, Dental and vision insurance, Health Savings Account, Healthcare Flexible Spending Account, Life insurance, Long-term disability leave, Dependent daycare spending account, Tuition assistance/reimbursement, and Simple Steps (global well-being program).
Principal Product Manager, Software: Identity, Security and Compliance SonosPrincipal Product Manager, Software: Identity, Security and ComplianceBoston, MassachusettsHands-on experience using AI tools (e.g., for research synthesis, spec drafting, data analysis, prototyping, or workflow automation) to move faster and work leaner — and genuine enthusiasm for continuing to evolve how PM work gets done. Define and champion the vision, roadmap, and success metrics for global identity management, platform security, and regulatory compliance within the Sonos software ecosystem — including authentication, authorization, data privacy (e.g., GDPR, CCPA), identity profiles and roles, and related critical initiatives.
Sr. Principal Scientist, Oral Drug Product Development BiogenSr. Principal Scientist, Oral Drug Product DevelopmentCambridge, MassachusettsRegular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. Serve as the senior drug product representative on cross-functional CMC and asset teams, driving alignment across regulatory, quality, manufacturing, analytical, clinical pharmacology, DMPK, and external partner functions.
Principal Product Manager, AI Infrastructure and Orchestration DataRobotPrincipal Product Manager, AI Infrastructure and OrchestrationBoston, WashingtonIt does not own agent coordination and authoring (planner and router logic, memory strategy, multi-agent handoff, builder surfaces), workflow orchestration in the Airflow or Temporal sense, model quality and applied research, or cluster fabric work such as InfiniBand and RoCE tuning for distributed training. Deep technical understanding of GPU and accelerator behavior: topology-aware placement, fractional and time-sliced sharing, MIG, device plugins and the driver and container runtime plumbing underneath them, memory as the binding constraint, and what utilization costs when a tenant holds a GPU it is not saturating.
Principal, Process Architecture Barry-WehmillerPrincipal, Process ArchitectureBoxborough, MA$170,000–$240,000 / yearBy blending people-centric leadership with disciplined operational strategies and purpose-driven growth, Barry-Wehmiller has become a $3 billion organization with nearly 12,000 team members united by a common belief: to use the power of business to build a better world. Rooted in our distinct culture of Truly Human Leadership, we cultivate the leaders who will define tomorrow and partner with our clients in the food & beverage, life sciences, industrial, and advanced technology industries to build the future of manufacturing and technology.
Senior Associate Scientist/ Principal Research Associate, Antibody and Protein Engineering Mediar Therapeutics IncSenior Associate Scientist/ Principal Research Associate, Antibody and Protein EngineeringBoston, MAAssociate Scientist Antibody and Protein Engineering Reports To: Scientist II, Antibody Engineering Position: Mediar Therapeutics is a clinical stage biotechnology company developing therapeutics to halt, or even reverse, fibrosis and restore long-term organ function. Associate Scientist Level - mimimum of 2 years of industry R&D experience (and B.S) Senior Associate Scientist Level - minimum of 5 years of industry R&D experience (with B.S) or 3 years of industry R&D experience (with M.S) Demonstrated hands-on experience with mammalian cell culture, recombinant protein expression, and protein purification.
Senior Principal Cyber Security Specialist, Culture Lead Medtronic PlcSenior Principal Cyber Security Specialist, Culture LeadBoston, MAIf you are applying to perform work for Medtronic, Inc. ("Medtronic") in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. Bring deep cybersecurity and program leadership experience, including success leading large, cross-functional initiatives, influencing senior stakeholders, and building enterprise-wide awareness and behavior-change programs in complex environments.
Senior Principal IT Architect - SAP Business AI Platform, S/4 HANA, and ABAP MedtronicSenior Principal IT Architect - SAP Business AI Platform, S/4 HANA, and ABAPBoston, MinnesotaIf you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. The following benefits and additional compensation are available to those regular employees who work 20+ hours per week: Health, Dental and vision insurance, Health Savings Account, Healthcare Flexible Spending Account, Life insurance, Long-term disability leave, Dependent daycare spending account, Tuition assistance/reimbursement, and Simple Steps (global well-being program).
Senior Principal Scientist Oligonucleotides Amgen IncSenior Principal Scientist OligonucleotidesCambridge, MAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Amgen is currently seeking a talented Senior Principal Scientist who will lead a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes, drive capacity expansion projects, and lead technology transfers for oligonucleotides.