NewHead of Growth JobotHead of GrowthSan Francisco, CA$200,000–$250,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Our platform helps high-growth startups and frontier technology companies automate and scale complex operational workflows that have historically been handled through fragmented, manual, and service-heavy processes.
NewProject Manager JobotProject ManagerRichmond, CA$130,000–$200,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. This role is pivotal in managing the planning, implementation, and execution of K12/K14 DSA construction projects to ensure they are completed in a timely fashion and within budget.
DSP Supported and Independent Living Lead ToolworksDSP Supported and Independent Living LeadSF, CAPer diemToolworks' Community Living Department is seeking dedicated and compassionate Direct Support Professionals (DSPs) for Case Lead roles in both Independent Living Services (ILS) and Supported Living Services (SLS) programs. As a Case Lead DSP in our Supported Living (SLS) program, you'll provide in-home instruction, case management, and daily living skills training to individuals with developmental and physical disabilities.
NewAssistant Project Manager - Commercial HVAC JobotAssistant Project Manager - Commercial HVACAlameda, CA$115,000–$135,000 / yearThe Assistant Project Manager is a full-time role that supports Project Managers and Project Executives by coordinating multi-department efforts to deliver HVAC and plumbing construction projects on schedule, on budget, and to specification. Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal.
NewHeavy Civil/Industrial Project Manager - Water/Wastewater JobotHeavy Civil/Industrial Project Manager - Water/WastewaterLivermore, CA$120,000–$150,000 / year2. Proven experience in managing water and wastewater construction projects, including experience with underground utilities, pump stations, site work, structural concrete, - knowledge of process piping, mechanical piping, and yard piping a plus! Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal.
NewLicensed Project Manager JobotLicensed Project ManagerSan Francisco, CA$110,000–$130,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. o Design of nonstructural components, including architectural features and components, metal stud framing, equipment anchorage, and seismic bracing of equipment and MEP distribution systems.
NewCustomer Success Manager JobotCustomer Success ManagerSan Francisco, CA$120,000–$165,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. By applying for this job, you agree to receive calls, AI-generated calls, text messages, or emails from Jobot, and/or its agents and contracted partners.
NewAssistant Project Manager - Construction JobotAssistant Project Manager - ConstructionPetaluma, CA$100,000–$120,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. By applying for this job, you agree to receive calls, AI-generated calls, text messages, or emails from Jobot, and/or its agents and contracted partners.
NewProject Manager-HVAC JobotProject Manager-HVACAlameda, CA$130,000–$180,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. You’ll manage multiple projects, drive financial performance, support forecasting, and contribute to a collaborative culture while working across Design Build, Plan & Specification, Design Assist, and IPD delivery models.
NewStructural Project Manager JobotStructural Project ManagerSan Francisco, CA$100,000–$118,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Gain further understanding of the scope of other design consultants/trades (including architect, Geotech, civil, MEP engineers, etc.) to better communicate and coordinate the impact of other consultants’ design on structure and vice versa.
NewProject Manager/Project Executive JobotProject Manager/Project ExecutiveFremont, CA$140,000–$220,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. You will be responsible for managing and overseeing multiple construction projects from conception to completion, ensuring that they are completed in a timely and cost-effective manner.
NewProject Manager - Roofing (Commercial & Residential) JobotProject Manager - Roofing (Commercial & Residential)Emeryville, CA$100,000–$140,000 / yearCommercial Projects Include: GAF | Garland | Firestone | Duro-Last | American Hydro-Tech (Garden Roof Systems) | Carlisle | Soprema | United Coatings | AEP Span (Metal Roofing) | GACO | Henry’s Roofing & Maintenance Systems | IB Thermoplastic Roofing Systems | Performance Roof Systems. Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal.
NewArchitectural Practice Lead, Healthcare & Science JobotArchitectural Practice Lead, Healthcare & ScienceSan Francisco, CA$160,000–$185,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Serve as a trusted advisor to project teams and clients, offering insights into emerging trends, best practices, and strategies to achieve exceptional planning and design outcomes for healthcare environments.
NewSenior Project Manager - Luxury Residential Construction JobotSenior Project Manager - Luxury Residential ConstructionSan Francisco, CA$150,000–$190,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. + Understand, plan, and review the construction program including plan layout, equipment and manpower needs, budget, and schedule; making sure the project is completed in a timely manner.
NewSenior Project Manager JobotSenior Project ManagerSan Francisco, CA$140,000–$160,000 / yeara California Public Benefit Nonprofit Corporation that specializes in addressing affordable housing and homelessness needs in the Bay Area, is looking for Senior Project Manager to help oversee our teams and projects. Information collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal.
NewConstruction Assistant Project Manager JobotConstruction Assistant Project ManagerFremont, CA$100,000–$125,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. Qualifications: A working knowledge of electrical construction at a level normally acquired through completion of a 5-year electrical apprentice program or a bachelor's degree in construction engineering management or related field.
NewHVAC Service Contracts Rep JobotHVAC Service Contracts RepAlameda, CA$85,000–$115,000 / yearInformation collected and processed as part of your Jobot candidate profile, and any job applications, resumes, or other information you choose to submit is subject to Jobot's Privacy Policy, as well as the Jobot California Worker Privacy Notice and Jobot Notice Regarding Automated Employment Decision Tools which are available at jobot.com/legal. You will coordinate initial PMA visits, communicate with customers about scheduling and site requirements, support data accuracy, and help ensure renewals and retention efforts are handled professionally and on time.
NewDirector, Technical Accounting & Financial Reporting Vaco LLCDirector, Technical Accounting & Financial ReportingSan Francisco, CA$220,000–$260,000Determining compensation for this role (and others) at Vaco by Highspring depends upon a wide array of factors including but not limited to: the individual’s skill sets, experience and training; licensure and certification requirements; office location and other geographic considerations; other business and organizational needs. Determining compensation for this role (and others) at Vaco by Highspring depends upon a wide array of factors, including but not limited to:The individual’s skill sets, experience, and training; Licensure and certifications; Office location and other geographic considerations; Other business and organizational needs.
NewDeal Desk Manager Vaco LLCDeal Desk ManagerSan Francisco, CARemote$60–$65Determining compensation for this role (and others) at Vaco by Highspring depends upon a wide array of factors including but not limited to: the individual’s skill sets, experience and training; licensure and certification requirements; office location and other geographic considerations; other business and organizational needs. Determining compensation for this role (and others) at Vaco by Highspring depends upon a wide array of factors, including but not limited to:The individual’s skill sets, experience, and training; Licensure and certifications; Office location and other geographic considerations; Other business and organizational needs.
NewPersonal Trainer, Pine Street EquinoxPersonal Trainer, Pine StreetSan Francisco, CA$39.50–$70Instruct and demonstrate to members on the proper use of equipment and exercise techniques which may include operating equipment and dynamically moving weight up to 50 pounds. Our portfolio of brands is recognized globally with locations within every major city across the United States in addition to London, Toronto, and Vancouver. .
NewPersonal Trainer, Marina District EquinoxPersonal Trainer, Marina DistrictSan Francisco, CA$40.50–$72.50Under the guidance of two dedicated managers you will develop and refine an approach to programming, education, business, and financial planning that ensures your Personal Training career is as unlimited as your passion. Market and sell personal training programs to members and/or clients through phone calls, emails, and in-person interactions.
NewPersonal Trainer, Van Mission EquinoxPersonal Trainer, Van MissionSan Francisco, CA$39.50–$70Under the guidance of two dedicated managers you will develop and refine an approach to programming, education, business, and financial planning that ensures your Personal Training career is as unlimited as your passion. Bonus opportunities for eligible trainers such as, but not limited to: New Trainer Bonus, Tri Annual Incentive Bonus, Senior Trainer Annual Bonus, and Member Referral Bonus.
NewPersonal Trainer, San Francisco EquinoxPersonal Trainer, San FranciscoSan Francisco, CA$40.50–$72.50Spend time speaking with a Personal Training Recruiter about our world-renowned Equinox Fitness Training Institute (EFTI), accelerated career-growth opportunities, and why a Personal Training career at Equinox is as unlimited as your passion! For over twenty years EFTI has elevated our trainers to design comprehensive client fitness programs that are safe, effective and results driven.
NewEngineering Operations Technician, DCC Communities Amazon Data Services, Inc.Engineering Operations Technician, DCC CommunitiesSan Francisco, CAThese include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company’s reputation. Our Engineering Operations Technicians II (EOT’s) help keep them that way by working with the brightest minds from around the globe to help test and implement the newest technology and work practices to meet the demands of a changing market.
Senior Project Manager (Consultant) IT SoliSenior Project Manager (Consultant)Newark, CA$75–$95 / hourContractorWe are seeking an experienced and highly organized Senior Project Manager (Consultant) to lead and deliver strategic cross-functional initiatives across Information Technology, Cybersecurity, Digital Transformation, Data Analytics, and Business Systems. The ideal candidate will possess exceptional project management capabilities, strong stakeholder management skills, and experience operating within regulated life sciences environments.
Lead Technician Summit School ServicesLead TechnicianConcord, CAYou’ll handle advanced diagnostics and repairs on medium/heavy vehicles, oversee inspection readiness (DVIR, DOT/state), and guide technicians through preventive maintenance cycles so routes leave safe and on time. Summit School Services companies share a strong commitment to provide the highest level of transportation safety, quality transportation, outstanding customer service and positive employee relations.
NewGrowth Marketing Manager - Contract TalentBurst, Inc.Growth Marketing Manager - ContractSan Francisco, CARemote$100–$133 / hourAn agile marketer who is comfortable with an evolving team structure, and willing and able to put on many hats Solid track record of successfully managing and executing large-scale, complex, high volume B2C email campaigns and cross-functional projects. You will be a thought partner and trusted stakeholder to functional leads and business partners across Product, Data Science, Business Ops, Host Community, Marketing, Brand, and Creative teams to set and exceed aggressive growth targets.
NewBiospecimen Acquisition and Data Specialist - Contract TalentBurst, Inc.Biospecimen Acquisition and Data Specialist - ContractPleasanton, CA$46.40–$46.40 / hourFacilitate cross-functional alignment with local and global stakeholders, including Procurement, Legal, Safety, Quality, and Logistics (Import/Export). You have prior experience navigating a highly complex, global matrix environment to align cross functional stakeholders.
NewSenior Project Manager - Contract TalentBurst, Inc.Senior Project Manager - ContractNewark, CAManage projects involving Identity and Access Management (IAM), including user lifecycle management, role-based access controls (RBAC), Single Sign-On (SSO), Multi-Factor Authentication (MFA), Privileged Access Management (PAM), and identity governance initiatives. We are seeking an experienced and highly organized Senior Project Manager (Consultant) to lead and deliver strategic cross-functional initiatives across Information Technology, Cybersecurity, Digital Transformation, Data Analytics, and Business Systems.
NewManager, Non Card Strategic Partnerships Visa Technology and Operations LLCManager, Non Card Strategic PartnershipsSan Francisco, CA$169,100–$270,800 / yearThe focus is on shaping compelling client narratives, structuring end‑to‑end solutions, and enabling large, complex partnerships (Bigtech) that accelerate adoption and revenue across Visa’s non‑card and acceptance platforms. This role leads strategic partnerships, client solutioning, and narrative development for Visa Pay and Visa Accept, working with priority partners such as banks, wallets, fintech's, merchants, and ecosystem enablers.
Senior Manager, External Data Products Visa Technology and Operations LLCSenior Manager, External Data ProductsFoster City, CA$169,100–$270,800 / yearWorking closely with Visa’s Chief Privacy Officer, the Technology organization, Government Solutions, the wider data community, and the full set of Visa’s global lines of business, the Global Data Office is evolving Visa’s data and AI-related work with momentum and enthusiasm. Visa is a world leader in payments technology, facilitating transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories, dedicated to uplifting everyone, everywhere by being the best way to pay and be paid.
Manager, Stablecoin Strategic Initiatives Visa Technology and Operations LLCManager, Stablecoin Strategic InitiativesSan Francisco, CA$146,200–$233,700 / yearp>As a Manager on the Crypto Strategic Initiatives Team within Growth Products and Partnerships at Visa, you will be responsible for driving execution of key strategic initiatives (or major workstreams within Initiatives) for Visa’s crypto efforts. Visa is a world leader in payments technology, facilitating transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories, dedicated to uplifting everyone, everywhere by being the best way to pay and be paid.
Applications Program Analyst Visa Technology and Operations LLCApplications Program AnalystFoster City, CA$123,000–$190,900 / yearPreferred Qualifications • 2 years or more with an Advanced Degree (Masters/PhD in Computer Science) • Proficiency in implementing and fine-tuning AI models using popular frameworks (e.g., TensorFlow, PyTorch, scikit-learn) • Exposure to leading-edge areas such as Machine Learning, Deep Learning, Stream Computing and MLOps. Translate complex business challenges into clear engineering roadmaps, user requirements, and technical specifications that enable breakthrough innovation across payment flows, fraud intelligence, data products, and real‑time commerce platforms.
Senior Product Delivery Manager Visa Technology and Operations LLCSenior Product Delivery ManagerFoster City, CA$169,100–$270,800 / yearWe’re looking for a high-agency Senior Product Delivery Manager to lead cross-functional delivery efforts for new products and enhancements across Visa Direct, ensuring successful execution from concept to market. Visa is a world leader in payments technology, facilitating transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories, dedicated to uplifting everyone, everywhere by being the best way to pay and be paid.
Sr Manager, Business Planning & Ops - Community Sales Visa Technology and Operations LLCSr Manager, Business Planning & Ops - Community SalesSan Francisco, CA$130,600–$246,200 / yearVisa is a world leader in payments technology, facilitating transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories, dedicated to uplifting everyone, everywhere by being the best way to pay and be paid. The Senior Manager, Business Planning and Operations – Community Sales is a senior individual contributor role responsible for enabling execution excellence across the North America Community Sales segment.
Senior Manager, B2B Agentic Commerce Partnerships Visa Technology and Operations LLCSenior Manager, B2B Agentic Commerce PartnershipsFoster City, CA$169,100–$270,800 / yearVisa is a world leader in payments technology, facilitating transactions between consumers, merchants, financial institutions and government entities across more than 200 countries and territories, dedicated to uplifting everyone, everywhere by being the best way to pay and be paid. This role is execution‑focused and partner‑facing, with responsibility for developing partnerships, structuring and closing pilot agreements, and running partner pilots from concept through production validation.
Program Manager - Marketing Events I Pinnacle Technical ResourcesProgram Manager - Marketing Events ISan Francisco, CaliforniaContractorCore Responsibilities:Operational Support and Logistics: Partner with the Global Strategic Event Manager to execute a high volume of logistics-heavy events, taking ownership of the day-to-day moving parts, planning timelines, and execution. Job Description:Client is hiring for an execution-focused Events Lead, Recruiting Programs to deliver of a high-volume, high-touch event portfolio spanning both recruiting events and intern program experiences.
NewCommercial Branch Manager OrkinCommercial Branch ManagerConcord, CA$85,000–$100,000When you’re an Orkin Branch Manager, you’re the leader cultivating a team to deliver top-notch service from the industry leader with more than 120 years of protecting homes and businesses. Founded in 1901, Orkin is a global residential and business service provider who provides the most accurate, comprehensive, and efficient pest management services for both residential and commercial customers.
NewOB-GYN Hospitalist Needed in California for New Program Development CHG HealthcareOB-GYN Hospitalist Needed in California for New Program DevelopmentRedwood City, CARedwood City is a San Francisco Bay Area community located in the heart of Silicon Valley, the technology-rich region extending from the San Francisco Peninsula to the foothills of the Santa Cruz Mountains. Rates shown are all-inclusive and combine an hourly base pay with other potential earnings like overtime, call, and holiday pay.
NewTraffic Control Supervisor II Roadsafe Traffic SystemsTraffic Control Supervisor IIAmerican Canyon, CA$25–$28 / hourTheir duties include using traffic control devices to divert drivers and pedestrians, monitoring road repairs, and supervising teams as they install equipment. Basic reading and writing ability to comply with road signs, complete paperwork, and knowledge of federal and state motor carrier safety regulations.
NewTraffic Control Supervisor II RoadSafe Traffic SystemsTraffic Control Supervisor IIAmerican Canyon, CA$25–$28 / hourTheir duties include using traffic control devices to divert drivers and pedestrians, monitoring road repairs, and supervising teams as they install equipment. Basic reading and writing ability to comply with road signs, complete paperwork, and knowledge of federal and state motor carrier safety regulations.
NewFire Director 4LEAF, IncFire DirectorPleasanton, CA$151,143–$179,378 / yearAs one of the industry’s notable providers of planning, building and safety, engineering, construction management, and fire consulting services, 4LEAF has an enviable track record of completing complex projects and staffing assignments with both public and private clients. Under general administrative direction, plans, organizes, manages, and directs the activities of the Fire Prevention Division, including fire inspection services, fire code enforcement, building and fire protection system plan review, permit processing, and public fire safety programs.
NewResident Services Manager Sares-Regis GroupResident Services ManagerOakland, CA$30–$35 / hourSares Regis Group of Newport Beach, California, is a privately held real estate development, investment and management firm that focuses on commercial properties and multifamily communities in the western U.S. Since its founding in 1993, SRG has developed and acquired more than $7 billion in commercial and residential assets. Act as the communication center providing residents community happenings daily, weekly, or monthly via the computer portal and postings.
NewPart -Time Resident Services Coordinator Sares-Regis GroupPart -Time Resident Services CoordinatorOakland, CA$25–$30 / hourSares Regis Group of Newport Beach, California, is a privately held real estate development, investment and management firm that focuses on commercial properties and multifamily communities in the western U.S. Since its founding in 1993, SRG has developed and acquired more than $7 billion in commercial and residential assets. Act as the communication center providing residents community happenings daily, weekly, or monthly via the computer portal and postings.
NewManufacturing Program Manager Davron LLCManufacturing Program ManagerFremont, CAVery familiar with Open Order Reports, including tracking customer purchase orders, current production status, due dates, ship dates, backorders, and potential late orders. Manage and update the MRP system, download and analyze customer data to reconcile accounts, and collaborate across internal departments to track orders and manage escalations.
NewAssociate Director, Field Marketer (Central - South) - Remote Agios PharmaceuticalsAssociate Director, Field Marketer (Central - South) - RemoteSan Francisco, CARemote$153,541–$230,312 / yearThe current base salary range for this position is expected to be between $153,541 and $230,312 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities.
NewAssociate Director, Translational Medicine Agios PharmaceuticalsAssociate Director, Translational MedicineSan Francisco, CA$153,541–$230,312 / yearThe current base salary range for this position is expected to be between $153,541 and $230,312 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities.
NewAssociate Director, Field Marketer (Southwest) - Remote Agios PharmaceuticalsAssociate Director, Field Marketer (Southwest) - RemoteSan Francisco, CARemote$153,541–$230,312 / yearThe current base salary range for this position is expected to be between $153,541 and $230,312 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities.
NewAssociate Director, Global Safety Lead - Remote Agios PharmaceuticalsAssociate Director, Global Safety Lead - RemoteSan Francisco, CARemote$185,369–$308,948 / yearo The current base salary range for this position is expected to be between $185,369 and $308,948 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. • Proactively assesses and evaluates the clinical implications of safety data from all sources in order to understand and communicate the benefit-risk profile of assigned drugs in development and in the post-marketing settings as appropriate .