NewPhysical Therapist- 15K Sign On Bonus Pappas OPT Physical and Hand TherapyPhysical Therapist- 15K Sign On BonusHanson, MA$80,000–$100,000 / yearConfluent Health is a family of physical therapy and occupational therapy companies transforming healthcare by strengthening private practices, developing highly effective clinicians, and lowering healthcare costs through workplace wellness and injury prevention. In this role, you’ll evaluate and treat patients in an outpatient setting, develop and implement individualized plans of care, and track clinical outcomes to support patient progress.
NewPhysical Therapist Pappas OPT Physical and Hand TherapyPhysical TherapistMedway, MA$80,000–$100,000 / yearConfluent Health is a family of physical therapy and occupational therapy companies transforming healthcare by strengthening private practices, developing highly effective clinicians, and lowering healthcare costs through workplace wellness and injury prevention. In this role, you’ll evaluate and treat patients in an outpatient setting, develop and implement individualized plans of care, and track clinical outcomes to support patient progress.
NewFinancial Analyst - SAP Vaco LLCFinancial Analyst - SAPDracut, MA$100,000–$130,000Determining compensation for this role (and others) at Vaco by Highspring depends upon a wide array of factors including but not limited to: the individual’s skill sets, experience and training; licensure and certification requirements; office location and other geographic considerations; other business and organizational needs. Determining compensation for this role (and others) at Vaco/Highspring depends upon a wide array of factors including but not limited to the individual’s skill sets, experience and training, licensure and certifications, office location and other geographic considerations, as well as other business and organizational needs.
NewDirector of Labor Relations Lesley UniversityDirector of Labor RelationsCambridge, MA$115,705–$131,392 / yearAt Lesley University we strive for a supportive and equitable environment where people -- regardless of race, ethnicity, color, sex, physical ability, religion, national origin or ancestry, age, neurodiversity, sexual orientation, gender identity or expression, genetic information, veteran or military status, membership in uniformed services, and all other categories protected by applicable state and federal laws -- can participate equally and fully as their true selves in all aspects of university life. In doing so, Lesley strives for a campus culture and community that fosters a true sense of belonging for all, provides opportunity for everyone to participate equally and fully in the Lesley experience, and helps to develop each individual's capacity to confidently and competently engage within and across difference.
NewSenior Director and Regulatory Platform Lead GRA CMC, Device and Drug-Device Combinations Human Factors Takeda PharmaceuticalSenior Director and Regulatory Platform Lead GRA CMC, Device and Drug-Device Combinations Human FactorsBack Bay, MA$212,000–$333,190 / yearAs Senior Director and Regulatory Platform Lead GRA CMC, Device and Drug-Device Combinations Human Factors, you will provide leadership for the development and implementation of innovative pure device and combination product regulatory strategies particularly pertaining to the development, registration, commercialization and life cycle management with a focus on Human Factors, ensuring that regulatory filings are of high quality and right first time. Works effectively across a complex matrix environment in GRA with GRLs, CMC RA project leads and other GRA sub-functions (e.g., Growth & Emerging Markets, Strategy, Labelling, etc.) to ensure effective strategies are implemented and project execution is on target.
NewSenior Manager, Regulatory Lead Takeda PharmaceuticalSenior Manager, Regulatory LeadBack Bay, MA$137,000–$215,270 / yearAssists in the creation and submission of high quality, compliant regulatory documents (e.g., BLAs, INDs, CTAs, MAAs, Variations/Supplements and other relevant regulatory filings such as PIPs/PSPs, ODDs, meeting requests and briefing packages) for assigned programs within defined timelines as per R&D and business objectives. See Takeda Pharmaceutical Terms of Use at https://www.takeda.com/terms-of-use/ and Privacy Policy at https://www.takeda.com/privacy-notice/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions.
NewMedical Director, Clinical Science - Solid Tumor Takeda PharmaceuticalMedical Director, Clinical Science - Solid TumorBack Bay, MA$237,200–$372,790 / yearAssesses scientific, medical, and development feasibility, evaluating strategic fit with overall portfolio, evaluating complete or ongoing clinical trials, assessing regulatory interactions and future development plans, interacting with upper management of potential partner/acquisition companies during DD visits and alliance negotiations, and representing clinical science on internal assessment teams in conjunction with TPNA/TPEU/TPC. These responsibilities include leadership roles in meetings with the regulatory organizations or key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g.
NewOperations Supervisor gategroupOperations SupervisorChelsea, MA$60,000–$64,000 / yearThe position is responsible for supervising thirty plus food production employees in a unionized environment to ensure security, safety, food specifications, quality assurance of products, sanitation, HACCP, USDA and FDA regulations are followed and are responsible for labor and Material cost controls. See gategroup Privacy Policy at https://www.gategroup.com/data-privacy/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions.
Vice President, Human Resources - Analytical Sciences Waters CorporationVice President, Human Resources - Analytical SciencesMilford, MAThe Vice President, Human Resources serves as the senior HR leader for the Analytical Sciences business unit and as a principal advisor to the Analytical Sciences SVP and executive leadership team. • Act as a trusted advisor to senior leaders on organizational capability, leadership effectiveness, succession, and workforce strategy.
Van Driver / MiniBus Driver - Hudson Summit School ServicesVan Driver / MiniBus Driver - HudsonHudson, NHCompletes all required paperwork (including route change sheets, time cards, vehicle repair requests) and submits to the appropriate authority in a timely manner. · Maintains a cooperative attitude with fellow employees, supervisors, customers, and passengers while always promoting company goodwill.
NewAssociate Director, Global Regulatory Affairs Marketed Products Takeda PharmaceuticalAssociate Director, Global Regulatory Affairs Marketed ProductsBack Bay, MARemote$154,400–$242,550 / yearAccountable for execution of global regulatory strategy including the provision of global regulatory submissions to local Takeda affiliates in compliance with local regulatory working with regional leads, other functions and vendors. As an Associate Director, Global Regulatory Affairs Marketed Products you will: Lead/Contribute global strategies to maximize global regulatory success towards achievement of program objectives for complex and/or multiple projects.
NewDirector, Global Regulatory Labeling Strategy Takeda PharmaceuticalDirector, Global Regulatory Labeling StrategyBack Bay, MARemote$177,000–$278,080 / yearConducts precedent searches, analyzes relevant competitor labeling, health authority labeling requests for Takeda products, labeling guidance and trends; and develops strategies and labeling language for inclusion assigned product labels (TLP, CCDS, USPI, EU SmPC, others as appropriate) to ensure consistency with the overall product strategy, product claims and information in the CCDS and to ensure that Takeda products have the most competitive labeling possible; while maintaining awareness of recent in-class approvals. In alignment with TAU/MPD Labeling Lead, coordinates the process to obtain labeling approval by Labeling Senior Management Cross-functional team (Global Labeling Oversight Committee - GLOC) providing leadership to foster cross-functional collaboration and drive alignment of the labeling strategy and labeling content at all levels.
Financial Reporting Analyst Kforce Inc.Financial Reporting AnalystBoston, MA$32–$36This role will partner with business units across the organization to monitor financial performance, develop forecasting models, analyze budget trends, and provide actionable insights to support strategic decision-making. Overview: We are seeking a Senior Budget and Financial Analyst to support organizational leadership by providing financial planning, budgeting, forecasting, and analytical expertise.
NewSenior Manager, Clinical Partner Outsourcing Takeda PharmaceuticalSenior Manager, Clinical Partner OutsourcingBack Bay, MARemote$137,000–$215,270 / yearLead ballparking, contracting and commercial management of complex clinical studies, understanding study requirements and translating into robust supplier contracts across a broad category of suppliers supporting R&D activities for assigned therapeutic areas and studies. The Senior Manager, Clinical Partner Outsourcing (CPO) ensures seamless execution of clinical studies by developing robust supplier contracts through commercial negotiations and resolving commercial and operational challenges.
Dialysis Clinical Manager Registered Nurse - RN Fresenius Medical CareDialysis Clinical Manager Registered Nurse - RNQuincy, MA$99,694–$166,109 / yearOther: • Collaborates closely with, providing oversight as needed to, the Clinical Manager/Charge RN acting as nurse manager, the Medical Director, and the physicians regarding the direct patient care responsibilities within the facility to ensure the provision of outstanding quality of patient care, as defined by the FMS quality goals, and compliance with the pertinent company policies and procedures. • Demonstrated leadership competencies and management skills for the position, including excellent communication, customer service, continuous quality improvement, relationship development, results orientation, team building, motivating employees, performance management and decision making.
Van Driver / MiniBus Driver - Nashua Summit School ServicesVan Driver / MiniBus Driver - NashuaNashua, NHCompletes all required paperwork (including route change sheets, time cards, vehicle repair requests) and submits to the appropriate authority in a timely manner. · Maintains a cooperative attitude with fellow employees, supervisors, customers, and passengers while always promoting company goodwill.
Van Driver / MiniBus Driver - Manchester Summit School ServicesVan Driver / MiniBus Driver - ManchesterManchester, NHCompletes all required paperwork (including route change sheets, time cards, vehicle repair requests) and submits to the appropriate authority in a timely manner. · Maintains a cooperative attitude with fellow employees, supervisors, customers, and passengers while always promoting company goodwill.
NewExecutive Director, Global Regulatory Affairs CMC Devices and Drug-Device Combination Product Takeda PharmaceuticalExecutive Director, Global Regulatory Affairs CMC Devices and Drug-Device Combination ProductBack Bay, MA$238,000–$374,000 / yearAs Executive Director, Global Regulatory Affairs CMC Devices and Drug-Device Combination Product, you will provide strategic leadership and development to global regulatory subject matter experts to ensure innovative and robust regulatory strategies for medical devices and drug-device combination products, maximizing global regulatory success and minimizing time to approval/clearance. Leads and develops a team of regulatory leaders and subject matter experts, overseeing global regulatory strategy and major submissions for an assigned portfolio of medical devices and drug-device combination products, ensuring clear strategy, high-quality execution, and timely approvals/clearances.
NewAssociate Medical Director, Clinical Science, NS TAU Takeda PharmaceuticalAssociate Medical Director, Clinical Science, NS TAUCambridge, MA$198,500–$311,850 / yearProvides leadership in meetings and negotiations with key opinion leaders, establishment of strategy for assigned compounds, and the direction of clinical scientists involved in developing documents required to outline the Company positions on research programs or regulatory applications (e.g. Contributes to the development and negotiation of clinical development plans for potential alliances and or in-licensing opportunities, interacts with upper management of potential partner/acquisition companies during DD visits and alliance negotiations and represents clinical science on internal assessment teams.
Senior Director, Strategic & Named Accounts - Healthcare - Remote InfobloxSenior Director, Strategic & Named Accounts - Healthcare - RemoteBoston, MARemoteHere, how we empower our people is extraordinary: Glassdoor Best Places to Work 2025, Great Place to Work-Certified in five countries, and Cigna Healthy Workforce honors three years running — and what we build is world-class: recognized as CybersecAsia’s Best in Critical Infrastructure 2024 — evidence that when first-class technology meets empowered talent, remarkable careers take shape. This role requires a proven enterprise sales executive with a track record of scaling high-performing organizations, developing leaders, building executive customer relationships, and consistently exceeding aggressive growth targets within cybersecurity, networking, cloud, SaaS, or adjacent enterprise technology markets.
NewDirector, Global Regulatory Affairs, Neuroscience Takeda PharmaceuticalDirector, Global Regulatory Affairs, NeuroscienceBack Bay, MARemote$177,000–$278,080 / yearDemonstrates acceptable skills with increasing independence in the area of regulatory strategy such as understanding broad concepts within regulatory affairs and implications across the organization and globally; proactively identifies regulatory issues; offers creative solutions and strategies, including risk mitigation strategies. Defines strategies and provides tactical guidance to teams and collaborates cross-functionally to ensure the global regulatory strategy is updated and executed, ensuring global regulatory compliance and/or oversees direct reports or junior staff responsible.
Clinical Trial Manager IconmaClinical Trial ManagerBoston, MA$26.16–$28.34 / hourAdvise RSP policy owner/committee chair on policy style, writing, programming; collaboration with subject matter experts; alignment of policy directives, procedural job aids, and committee direction. Identify available resources, including needed mentoring, partnerships, for example, SRG, scientific writing core, CCRO, biostats core, IRB, budget development].
NewHR Generalist (on site) gategroupHR Generalist (on site)Back Bay, MA$65,000–$70,000 / yearPartners with various levels of management to understand business objectives and identify corresponding human resource needs; implements strategies to support various business objectives and improve programs to support employee retention. Partners with operations to identify and understand workforce needs; may be responsible for recruiting union hourly employees and for assisting with recruitment for exempt and non-exempt positions.
NewSenior Manager, Global Regulatory Affairs CMC Takeda PharmaceuticalSenior Manager, Global Regulatory Affairs CMCBack Bay, MARemote$137,000–$215,270 / yearThis role is within the Global Regulatory Affairs (GRA) Chemistry Manufacturing & Controls (CMC) and Devices organization, and will contribute to the team’s delivery of critical functions as follows: This role is within in the GRA Chemistry Manufacturing & Controls (CMC) and Devices organization, and will contribute to the team’s delivery of critical functions as follows: With some supervision, leads the execution of regulatory CMC investigational, registration and/or post-approval strategies for assigned products. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
Acute Dialysis Services Program Manager - RN Fresenius Medical CareAcute Dialysis Services Program Manager - RNBoston, MA$105,206–$175,198 / yearConfer routinely with Technical Program Manager and Technical Operations Manager to ensure preventative maintenance program for routine machine maintenance, to ensure the timely repair of disabled machines, to coordinate infection control measures, routine culturing, water testing, logging of results, transportation of equipment and supplies and communicate technical information to the staff. Responsible for Acute Care Electronic System (ACES) include the following: Takes initiative and action to respond, resolve and follow up regarding customer service issues with all customers in a timely manner.
NewPallet Repair Operator - 2nd Shift CHEPPallet Repair Operator - 2nd ShiftWilmington, MAIn a repair department places pallet on repair table, removes defective boards, replaces new boards, and nails replaced boards into place. Accountability, Active Listening, Computer Literacy, Critical Thinking, Decision Making, Interpersonal, Managerial Confidence, Mathematic Literacy, Time Management, Verbal Communications.
NewExecutive Director, Global Regulatory Affairs CMC Early Development Takeda PharmaceuticalExecutive Director, Global Regulatory Affairs CMC Early DevelopmentBack Bay, MA$238,000–$374,000 / yearAccountable for ensuring global CMC content quality and compliance for early development submissions and lifecycle changes through Phase 2 (e.g., IND/CTA modules, IMPD quality sections, amendments, investigator’s brochure CMC, and responses to health authority questions), partnering with regional leads and technical functions to ensure consistent, inspection-ready documentation. Represents Global Regulatory Affairs CMC in senior-level governance and in interactions with global health authorities, including FDA, EMA, MHRA, PMDA, and other agencies as applicable, to enable efficient pathways for early development CMC strategies and submissions (e.g., pre-IND/IND/CTA, amendments, Type B/C meetings, scientific advice).
NewAssociate Director, Global Regulatory Affairs CMC Takeda PharmaceuticalAssociate Director, Global Regulatory Affairs CMCBack Bay, MA$154,400–$242,550 / yearProactively communicates CMC regulatory strategies, key issues and risks through assigned programs / products development activities and LCM in adequate and timely manner to cross-functional programs/ products teams and management level within GRA CMC, GRA, PS, GMS and QA - as appropriate. This role is within the Global Regulatory Affairs (GRA) Chemistry Manufacturing & Controls (CMC) and Devices organization, and will contribute to the team’s delivery of critical functions as follows: With minimal supervision, develops and leads the execution of regulatory CMC investigational, registration and/or post-approval strategies for assigned products.
NewSr. Associate, Fraud Transformation & Platform Enablement Santander Holdings USA IncSr. Associate, Fraud Transformation & Platform EnablementBoston, MAConduct comparative analysis of legacy fraud platforms and vendor provided tools and services, rules engines, case management tools, and industry best practices and benchmarking of control environments to determine optimal fraud prevention strategy (retain, sunset, integrate, upgrade or replace). Perform fraud systems and control analysis to support bank consolidation activities; Assess current state, analyze and compare fraud control environments, assess vendors, and recommend future state roadmap for maximum fraud control effectiveness.
NewSr. Associate, Application Development Santander Holdings USA IncSr. Associate, Application DevelopmentBoston, MAServes as a hands-on technical leader, actively contributing to application architecture, software design, code reviews, and complex development initiatives while providing day-to-day leadership, coaching, and direction to the development team. Provides strong leadership to the various team members through mentoring, career development, interpersonal skills, teamwork ethic, and enabling leadership skills.
Director - HCM IT Lead & Business Partner Waters CorporationDirector - HCM IT Lead & Business PartnerMilford, MAThe Director, IT HCM Lead & Business Partner is accountable for end to end leadership of Waters’ Human Capital Management (HCM) technology landscape, serving as both the IT HCM platform lead and the primary IT business partner to Human Resources Information Systems (HRIS). Acting as a trusted advisor to HRIS leadership, this role ensures HR capabilities are enabled through scalable, secure, and well governed technology solutions that support global workforce strategy, operational excellence, and continuous transformation.
NewPhysical Therapist- 15K Sign On Bonus ConfidentialPhysical Therapist- 15K Sign On BonusBryantville, MA$80,000–$100,000 / yearConfluent Health is a family of physical therapy and occupational therapy companies transforming healthcare by strengthening private practices, developing highly effective clinicians, and lowering healthcare costs through workplace wellness and injury prevention. In this role, you’ll evaluate and treat patients in an outpatient setting, develop and implement individualized plans of care, and track clinical outcomes to support patient progress.
Senior Manager/Associate Director, Global Safety Scientist, MSRM Agios PharmaceuticalsSenior Manager/Associate Director, Global Safety Scientist, MSRMCambridge, MA$153,541–$230,312 / yearManager level is expected to be between $131,035 and $196,553 annualized and the current base salary range for this position at the Associate Director level is expected to be between $153,541 and $230,312 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. The Global Safety Scientist will work closely with the Head of Safety Sciences and the Global Safety Leads and be responsible for leading and planning the development of aggregate safety reports, signal detection review, authoring and analyzing data for safety topic reports, and creation and update of risk management plans.
Enterprise Global Account Director - Remote DoceboEnterprise Global Account Director - RemoteBoston, MARemoteCollaborate Internally: Develop strong relationships with post-sales teams and coordinate internal resources, including Account Management, Marketing, Professional Services, Support, Product, and Client Success, to drive account strategy, deal closure, and customer satisfaction. Strategic Account Planning: Use extensive sales experience to provide territory and key account planning, steer prospecting efforts, and work with the Business Development team to drive net new opportunities.
Production Planner Shred-Tech CorporationProduction PlannerCambridge, ONThe Production Scheduler monitors production performance, maintains schedule integrity and key performance indicators, supports continuous improvement initiatives and proactively communicates risks that may impact customer delivery commitments while coordinating recovery plans to ensure on-time execution. The Production Planner is responsible for the overall ownership and execution of the short-term production schedule, ensuring work orders are released, prioritized and completed in alignment with customer requirements and available manufacturing capacity.
Manufacturing Engineer Shred-Tech CorporationManufacturing EngineerCambridge, ONWorking closely with cross-functional teams including Engineering, Production, Quality, Supply Chain and Operations, you will lead process improvement initiatives, support engineering change implementation and contribute to the successful execution of strategic manufacturing projects. As a Manufacturing Engineering Specialist at Shred-Tech, you will play a key role in optimizing manufacturing operations, supporting new product introductions, and driving continuous improvement initiatives across the organization.
Registered Nurse (RN) - Certified Home Health - earn $72.13 per point connectRNRegistered Nurse (RN) - Certified Home Health - earn $72.13 per pointQuincy, MA$74.80–$79.20Keywords: Registered Nurse, RN, RN Per Diem, Certified Home Health, OASIS, HomeCare HomeBase, Side Hustle, Flexible Hours, Per Diem, Competitive Pay, PRN. One-To-One Support & Clinical Mentorship: You work hard to care for so many, our team is dedicated to making sure that your questions are answered and that you feel supported day in and day out.
Associate Director, Clinical Assay Strategy, Flu CSL SeqirusAssociate Director, Clinical Assay Strategy, FluWaltham, MA$179,000–$212,000This role is intended for a recognized subject matter expert who understands the scientific, operational, and regulatory evolution of influenza immunogenicity assessment, including HAI, microneutralization (MN), ELLA, and multiplex platforms, and can strategically navigate assay modernization while maintaining regulatory alignment. Headquartered in Melbourne, Australia, with major manufacturing hubs in Holly Springs, NC, and Liverpool, UK, the company operates the world’s largest cell-based vaccine facility and serves as a primary partner to governments for global pandemic preparedness.
Director, Agentic Software Development CSL BehringDirector, Agentic Software DevelopmentWaltham, MA$228,000–$270,000We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas.
NewSenior Associate, Strategic Change Management KPMGSenior Associate, Strategic Change ManagementBoston, MAExcellent communication skills with the ability to lead conversations and create stakeholder engagement with clients and colleagues across an organizational hierarchy and strong demonstrated ability in AI, PowerPoint, Excel, MS Project and other Microsoft tools to develop work plans, articulate complex issues, analyze data and structure information. Manage scope, and junior resources on client engagements, while also identifying and mitigating any associated risks or issues; Deliver change management projects using AI/Agents with an Ability to build agents and analyze change workforce data.
Senior Director, Program Leader, Corporate Strategy Agios PharmaceuticalsSenior Director, Program Leader, Corporate StrategyCambridge, MA$229,562–$344,345 / yearDemonstrated ability to drive successful product launch and commercialization of innovative, first-in-class therapies, including lifecycle management (LCM) planning and execution; experience leading programs from late-stage development through commercial readiness and post-launch LCM strategies strongly desired. Define and continuously evolve the Target Product Profile, Clinical Development Plan, regulatory pathway, market access strategy, and commercial positioning in close partnership with cross-functional leaders and aligned with patient needs.
Senior Manager, Medical Affairs Operations - Remote Agios PharmaceuticalsSenior Manager, Medical Affairs Operations - RemoteBoston, MARemote$131,035–$196,553 / yearManage the execution of Agios’ patient advocacy conference plans for PK deficiency, thalassemia, and sickle cell disease; participate in cross-functional planning meetings; obtain compliance approval for related materials; and attend virtual and in-person conferences, when needed. Provide operational and project management support to the US patient advocacy team, ensuring smooth day-to-day coordination across priorities, stakeholders, and deliverables, and flex to support various other functions within Medical Affairs as needs arise.
Associate Director, G&A Business Systems Analyst, IT Agios PharmaceuticalsAssociate Director, G&A Business Systems Analyst, ITCambridge, MA$153,541–$230,312 / yearCreate and deliver documentation required per established project implementation process for each phase of SDLC including but not limited to creating User requirements doc, system impact assessment, Test plan, Test scripts, traceability matrix, training plan, communications plan, end user guides, RAID logs, status reports, data migration plan, etc. Interact and support core G&A platforms including and not limited to Oracle HCM, Icertis CMS, Oracle Financials, Taleo ATS in a hybrid internal/vendor delivery model, partnering closely with IT Solutions Architect, PMO, and MSP.
Senior Director, Immunology and Translation CSL BehringSenior Director, Immunology and TranslationWaltham, MA$302,000–$350,000You will bring end-to-end experience from early ideation through first-in-disease and will partner closely with cross-functional teams including discovery research, translational medicine, clinical development, and business development to shape and advance CSL Behring's immunology pipeline. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.