Senior/Principal Scientist, Small Molecule Therapeutics Lila SciencesSenior/Principal Scientist, Small Molecule TherapeuticsCambridge, Massachusetts$148,000–$208,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. Automation-forward mindset: experience operating in automation- and robotics-enabled labs, including liquid handling integration, assay automation, and designing scalable, reproducible experimental workflows.
Principal Embedded Software Engineer RISE RoboticsPrincipal Embedded Software EngineerSomerville, MAAs a pivotal member of the RISE Robotics Engineering organization, your contributions will shape the future of our company, spearheading the engineering effort to implement electronic controls of truly massive machines. Collaboration: Work closely with cross-functional teams, including mechanical engineers, electrical engineers, and application specialists, to achieve project goals.
Principal Software Engineer, Instrument Simulations Lila SciencesPrincipal Software Engineer, Instrument SimulationsCambridge, Massachusetts$204,000–$270,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Technical Program Manager, App Lila SciencesPrincipal Technical Program Manager, AppCambridge, Massachusetts$204,000–$270,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Principal Engineer, Geostructural - Mi-Tech Services, Inc. Michels CorporationPrincipal Engineer, Geostructural - Mi-Tech Services, Inc.Boston, MA$138,000–$207,000 / yearA Principal Engineer is a leadership role that focuses on overseeing and driving the technical direction of projects for specific geographical regions or scopes of engineering services. Currently holding a Structural Engineer (SE) license or having passed the NCEES 16-hour structural engineering exam with which to obtain an SE license via comity without additional testing needed.
Principal System Safety Engineer Avenue Technologies CompanyPrincipal System Safety EngineerWoburn, MassachusettsAvenue Technologies is seeking a Principal System Safety Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate across engineering, program, and customer-facing teams to identify hazards and define effective controls.
Principal Clinical Trial Manager TransMedics Group, Inc.Principal Clinical Trial ManagerAndover, MA$137,100–$193,700 / yearThis position is responsible for, but not limited to, the following: Leading the process of pre and post market clinical trials for FDA by employing effective organizational strategies and reviewing and presenting the results using rigorous clinical procedures. Experience in medical device (strongly preferred), Outstanding track record leading large complex global clinical trials for medical device products in different phases of the product cycle.
Staff/Principal DevOps Engineer, AI Inference Lila SciencesStaff/Principal DevOps Engineer, AI InferenceCambridge, Massachusetts$192,000–$272,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. This role bridges platform engineering, site reliability, and ML infrastructure, building the systems that power low-latency, high-throughput inference across GPU clusters and cloud accelerators.
Principal Engineer, AI Security Lila SciencesPrincipal Engineer, AI SecurityCambridge, Massachusetts$255,000–$348,000 / yearMulti-Layer AI Security (Network, Endpoint, Data) — Integrate AI security into existing enterprise security layers: network visibility and control over AI service access, API traffic inspection, and zero trust enforcement; endpoint security for developer machines, research environments, browsers, and plugins; data layer controls ensuring proper handling of sensitive data when interacting with AI systems. While Lila builds AI-powered systems, this role is primarily focused on securing the use of third-party and internally deployed AI tools across the enterprise — ensuring sensitive data, intellectual property, and scientific workflows are protected as AI becomes deeply embedded in how work gets done.
Principal Manufacturing Engineer Avenue Technologies CompanyPrincipal Manufacturing EngineerTewksbury, MassachusettsAvenue Technologies is seeking a Principal Manufacturing Engineer to support technical, engineering, and program teams in a hands-on environment. Lead or support root cause, corrective action, and continuous improvement activities using data-driven methods.
Principal Cybersecurity Engineer Avenue Technologies CompanyPrincipal Cybersecurity EngineerMarlborough, MassachusettsAvenue Technologies is seeking a Principal Cybersecurity Engineer to support technical, engineering, and program teams in a hands-on environment. Coordinate with engineering and program teams to maintain secure and compliant systems.
Principal Software Engineer, Berxi Vets HiredPrincipal Software Engineer, BerxiBoston, MassachusettsWe are seeking a highly skilled Principal Software Engineer to lead the design and delivery of scalable, cloud-native digital platform solutions in a direct-to-customer environment. This role plays a key part in shaping technical strategy, mentoring engineering teams, and building secure, high-performance applications that drive business growth.
Principal Performance Test Engineer BlockHiresPrincipal Performance Test EngineerBoston, MassachusettsWe are uniquely positioned at the center of global trading activity, processing over 100 million financial transactions every day, pioneering industry-wide, post-trade solutions and maintaining multiple data and operating centers worldwide. This highly technical position is responsible for the performance engineering of DTCC distributed computing environments and providing analytical stress evaluations of applications/systems and service level compliance using statistical, analytical, and simulation methods.
Associate Principal Threat Intelligence Analyst Rockstar GamesAssociate Principal Threat Intelligence AnalystAndover, MA$125,000–$150,000 / yearIf hired, employee will be in an "at-will position" and the company reserves the right to modify base salary (as well as any other discretionary payment or compensation or benefit program) at any time, including for reasons related to individual performance, company or individual department/team performance, and market factors. Become part of a team working on some of the most rewarding, large-scale creative projects to be found in any entertainment medium - all within an inclusive, highly-motivated environment where you can learn and collaborate with some of the most talented people in the industry.
Principal Associate I, Plant Quality Assurance - 2ND SHIFT ReplimunePrincipal Associate I, Plant Quality Assurance - 2ND SHIFTFramingham, Massachusetts$120,000–$155,000 / yearThe Principal Associate I/II, Plant Quality Assurance (PQA) reports to the Associate Director, Quality Assurance and is responsible for on-going Quality oversight to ensure real time quality oversight for Drug Substance, Drug Product, and all other production and QC testing activities according to current good manufacturing practices (cGMP), good documentation practices (GDP) and other applicable regulations. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Principal Systems Management Analyst - Epic Healthy Planet UnitedHealth Group Inc.Principal Systems Management Analyst - Epic Healthy PlanetAuburndale, MA$112,700–$193,200 / yearAs a Principal Systems Management Analyst focusing on Epic Healthy Planet and Epic Cheers, you will partner with clinical, operational, and technical leadership to drive population health strategies and patient engagement workflows. Evaluate current-state workflows and identify opportunities to optimize Healthy Planet functionality to improve care gap closure, patient outreach, quality performance, and provider efficiency.
Principal Systems Engineer - CLEARANCE REQUIRED BelcanPrincipal Systems Engineer - CLEARANCE REQUIREDTewksbury, MAACTIVE US Secret Clearance REQUIREDDesired Skill Sets:* Experience using test equipment, software installations, and integrating or regression testing systems with certifications in CompTIA Network+ and or CompTIA Security+.* Experience with MATLAB, Linux Operating Systems (Linux Red Hat), Unix, Perl, C/C++, and Shell scripting for performing integration, verification and test analysis, integrating and configuring electronics/network routers, and installing/debugging software.* Experience with agile and DevSecOps processes, implement (or maintain) agile methodologies, participating in daily team standup meetings, sprint reviews, program Increment (PI) Planning meetings, retrospectives, and agile tooling such as JIRA and Confluence, and support execution of the team"s backlog including performance analysis and issue investigation.*
Principal Data Engineer CodaMetrixPrincipal Data EngineerBoston, Massachusetts$175,000–$200,000 / yearThe Data Platform team is responsible for executing the data strategy for the organization, ensuring high-quality external data is ingested into the Lakehouse and realized in powerful insights for internal and external customers, while ensuring ML/AI, BI and customer success teams have the data they need to develop and train their models, build insightful dashboards and design semantic layer. Cross-Functional Enablement & Mentorship - Enable ML, BI, Analytics, DevOps, and customer success and implementation teams with training data pipelines, model-ready datasets, feature store architecture, optimized views, dashboards, Tableau refreshes, infrastructure changes, and tenant onboarding.
Principal Mechanical Engineer, Process Equipment Boston MaterialsPrincipal Mechanical Engineer, Process EquipmentBillerica, MADesign and requisition mechanical machinery and components using CAD (SolidWorks preferred), ensuring design specifications are met, and manage design files, revisions, and workflows within a Product Data Management (PDM) system. 8+ years designing, building, and commissioning custom capital equipment in advanced materials, semiconductor packaging, battery, display, web converting, or other environments where the fidelity of a chemical or materials process must be preserved by the equipment design.
Principal Software Engineer Vets HiredPrincipal Software EngineerBoston, MassachusettsThe ideal candidate brings deep technical expertise, strong leadership, and a hands-on approach to building high-impact systems in a fast-paced, collaborative environment. This role plays a critical part in shaping technology strategy, driving architectural excellence, and mentoring engineering teams to support evolving business platforms.