Principal Scientist - Cardiometabolic Disorders AmgenPrincipal Scientist - Cardiometabolic DisordersThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Demonstrated experience developing, optimizing, and applying GPCR-based in vitro pharmacology assays, including functional signaling assays, ligand-binding assays, receptor internalization, -arrestin, cAMP, calcium mobilization, and pathway-selective (biased signaling) analyses.
Principal Scientist Algorithm Lead NeoGenomics IncPrincipal Scientist Algorithm LeadCARemoteArchitect and lead automated analytical validation frameworks spanning accuracy, precision, sensitivity/LOD, specificity, linearity, and robustness for SNVs, indels, CNVs, structural variants, gene fusions, and RNA‑based assays. Develop and track NGS‑based quality control metrics at the read, molecule, sample, and assay levels (e.g., coverage, uniformity, duplication/UMI yield, error rates, contamination, noise profiles) to monitor analytical performance and stability.
Associate Principal Scientist, Innovation - Scientific Affairs Liquid I.V.Associate Principal Scientist, Innovation - Scientific AffairsEl Segundo, California$116,100–$174,100 / yearWe know that the happiest and highest performing teams include people with diverse perspectives that encourage new ways of solving problems, so we strive to attract and develop talent from all backgrounds and create workplaces where everyone feels seen, heard, and empowered to bring their full, authentic selves to work. Our team members enjoy a flexible and inclusive working environment, a highly collaborative and innovation-forward culture, generous benefits and perks that empower employees to champion their wellbeing every day, as well as an infinite supply of Liquid I.V. for extraordinary hydration.
Principal Scientist - Modeling & Simulation AmgenPrincipal Scientist - Modeling & SimulationThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Principal Scientist – Chemical Biology & Proximity-Based Therapeutics AmgenPrincipal Scientist – Chemical Biology & Proximity-Based TherapeuticsThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Principal Scientist – Inflammation Human Data & Computational Biology AmgenPrincipal Scientist – Inflammation Human Data & Computational BiologyThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Sr. Principal Scientist - Project Toxicologist AmgenSr. Principal Scientist - Project ToxicologistThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Process Development Senior Principal Scientist AmgenProcess Development Senior Principal ScientistThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. This candidate will integrate formulation, analytical, and process data to guide product design, apply cutting-edge technologies (including AI/ML), and collaborate cross-functionally to deliver high-quality, stable, and manufacturable drug products for development in a fast-paced environment.
Principal Scientist - Data Insights & Hypothesis Design Tempus AI IncPrincipal Scientist - Data Insights & Hypothesis DesignCA$150,000–$200,000 / yearData Engineering & Scale Architecture: Proven experience collaborating directly with data engineering and platform teams to build large-scale relational databases, design advanced SQL data models, and support the robust infrastructure needed to create and deploy massive, production-grade models. Multi-Omic & NGS Modalities: Deep expertise executing multi-omic analyses across a diverse spectrum of high-throughput sequencing applications and biotechnologies, including specialized NGS modalities such as single-cell sequencing, immunomics, metagenomics, and varied sequencing platforms.
Associate Principal Scientist, Innovation - Scientific Affairs Liquid IVAssociate Principal Scientist, Innovation - Scientific AffairsEl Segundo, CA$116,100–$174,100 / yearWe know that the happiest and highest performing teams include people with diverse perspectives that encourage new ways of solving problems, so we strive to attract and develop talent from all backgrounds and create workplaces where everyone feels seen, heard, and empowered to bring their full, authentic selves to work. Functions and duties of this role include, but not limited to: Serve as a Scientific Affairs lead in the innovation engine, partnering with R&D, Regulatory, Brand Innovation, and other cross-functional teams to shape early-stage concepts and sprint work.
Principal Scientist – Lead Discovery and Targeted Protein Degradation Biochemistry AmgenPrincipal Scientist – Lead Discovery and Targeted Protein Degradation BiochemistryThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Process Development Sr Principal Scientist AmgenProcess Development Sr Principal ScientistThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Serve as a leader on Drug Product Commercialization Teams responsible for planning, designing, executing, and documenting laboratory studies related to drug product design, formulation, and process development in support of commercialization and lifecycle management of biologic drug product presentations.
Process Development Principal Scientist AmgenProcess Development Principal ScientistThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. The Amgen DPT leader will lead Drug Product Teams as a DPTL and represent the DP function on Product Development Teams to advance late-stage assets through commercial formulation and process development, process characterization, marketing application, and post-launch commercial maintenance.
Process Development Principal Scientist – Drug Product Technologies AmgenProcess Development Principal Scientist – Drug Product TechnologiesThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this vital role you will join the Pre-Pivotal Drug Product Technologies group, which is responsible for early-stage drug product development across diverse modalities, including antibody-drug conjugates (ADCs), oligonucleotides such as siRNAs, monoclonal antibodies, multispecifics, and other complex biologics.
Senior Principal Scientist AmgenSenior Principal ScientistThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this role you will mature core toxicology programs to manage patient safety and EHSS risks of Amgen products, including those from drugs, manufacturing materials, primary containers, and drug-delivery device combination products, as they advance from development to commercialization, and post-approval.
Principal Scientist - Clinical Pharmacology Modeling and Simulation AmgenPrincipal Scientist - Clinical Pharmacology Modeling and SimulationThousand Oaks, CaliforniaIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Develop integrated clinical pharmacology plans addressing key program questions related to PK, PD, exposure-response, dose and regimen selection, drug-drug interactions, intrinsic and extrinsic factors, special populations, ethnic sensitivity, formulation changes/biopharmaceutics.
Associate Principal Scientist, Innovation Liquid IV IncAssociate Principal Scientist, InnovationEl Segundo, CA$116,100–$174,100 / yearWe know that the happiest and highest performing teams include people with diverse perspectives that encourage new ways of solving problems, so we strive to attract and develop talent from all backgrounds and create workplaces where everyone feels seen, heard, and empowered to bring their full, authentic selves to work. Functions and duties of this role include, but not limited to: Serve as a Scientific Affairs lead in the innovation engine, partnering with R&D, Regulatory, Brand Innovation, and other cross-functional teams to shape early-stage concepts and sprint work.
Architect, Machine Learning (Principal Scientist) Kinaxis IncArchitect, Machine Learning (Principal Scientist)CAAs part of the Product R&D organization, you will play a senior technical leadership role in applied AI, helping identify promising techniques, develop differentiated approaches, and shape how new ideas evolve into product capabilities. Our powerful, AI infused platform provides full transparency and visibility across end-to-end supply chains, enabling our customers to make faster, better decisions.
Principal Engineer/Scientist- Water Resources Exponent Inc.Principal Engineer/Scientist- Water ResourcesPasadena, California$211,500–$258,500 / yearFull timeFor over five decades, we've connected the lessons of past failures with tomorrow's solutions to advise clients as they innovate technologically complex products and processes, ensure the safety and health of their users, and address the challenges of sustainability. Work Environment: At Exponent, we have found that in-person interactions deepen employee engagement and are crucial for development, for realizing the full potential of our talented and diverse teams, and for building a more inclusive workplace where all have a sense of belonging.
Principal Engineer/Scientist Water Resources Exponent IncPrincipal Engineer/Scientist Water ResourcesPasadena, CA$211,500–$258,500 / yearFor over five decades, we''ve connected the lessons of past failures with tomorrow''s solutions to advise clients as they innovate technologically complex products and processes, ensure the safety and health of their users, and address the challenges of sustainability. To learn more about life at Exponent and our impact, please visit the following links: https://www.exponent.com/careers/life-exponenthttps://www.exponent.com/company/our-impact .