Scientist, Discovery Biology

Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle platform. With the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Advances Denali's oligonucleotide therapeutic pipeline by generating the in vivo and ex vivo evidence that guides candidate selection. Applies animal models, molecular and cellular assays, and pharmacokinetic and pharmacodynamic (PK/PD) studies to validate targets, identify biomarkers, and inform therapeutic development. Partners with Preclinical Translational Sciences, Developmental Sciences, Safety, and drug metabolism and pharmacokinetics (DMPK) scientists to move candidates through preclinical development. Delivers well-documented results that inform central nervous system (CNS) drug delivery and disease research decisions.

Key Accountabilities/Core Job Responsibilities:

• Design and execute in vivo and ex vivo studies that inform candidate progression, PK/PD modeling, and biomarker strategies
• Generate PK/PD data in preclinical models in partnership with Safety and DMPK scientists
• Perform molecular and biochemical assays, including RNA extraction, quantitative PCR, tissue sectioning, immunofluorescence, microscopy, and ELISAs
• Troubleshoot technical issues to keep experiments on schedule
• Evaluate oligonucleotide therapeutic candidates in CNS tissue-based models
• Analyze and interpret experimental data and report quantitative results
• Document experiments completely in electronic lab notebooks
• Present experimental designs and study results to cross-functional teams and collaborators
• Apply emerging scientific literature and technologies in CNS drug delivery and disease research to study design

Qualifications/Skills:

• Typically requires a PhD in Neuroscience, Cell Biology, Pharmacology, or a related scientific field; or a Master's degree and 3+ years of relevant experience in academia or pharmaceutical discovery/translational research
• Hands-on proficiency in wet lab techniques (for example RNA extraction, quantitative PCR, tissue sectioning, immunofluorescence, microscopy, and ELISAs)
• Experience with in vivo models and CNS tissue-based studies
• Strong scientific reasoning in experimental design and data analysis
• Strong verbal and written communication skills, with the ability to work independently, prioritize tasks, and adapt in a fast-paced research environment

Salary Range: $110,000.00 to $143,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.