Core knowledge should include: API Manufacturing Processes (Reactors, Filter Dryers, TCUs, Potent Isolators), Cleaning Methodologies (API/LM/SM), Management of Change, Process Hazard Analysis, Potent Compound Containment (OEB 4/5), Regulations/Industry Guidance (NEC Electrical Classification), PSV's, and Chemical Processing. Adhere to Project Change Control principles, ensuring all design changes are evaluated for cost, schedule, and safety impacts before securing necessary financial approvals to prevent unapproved scope creep while maintaining design integrity.