Principal Engineer - Security Products, Security Visibility DigitalOceanPrincipal Engineer - Security Products, Security VisibilityBoston, MARemote$235,200–$294,000 / yearEvolve the Audit Logging Platform: Lead the redesign of DigitalOcean's audit log infrastructure to support immutable, tamper-evident, compliance-grade event records with fine-grained retention controls, cross-account federation, and real-time streaming access for customers and internal security teams. Core Experience: You possess over 10 years of software engineering expertise, including 4+ years dedicated to audit logging, security telemetry, SIEM integration, or managing high-throughput data pipelines within cloud or IaaS ecosystems.
Principal Specialist, Quality Assurance Cardinal HealthPrincipal Specialist, Quality AssuranceMansfield, MassachusettsCross-functional Collaboration: Leads complex cross-functional projects to identify root causes of significant quality issues, educates stakeholders on quality requirements, and develops sustainable solutions to minimize future risks. The Principal Specialist, Quality Assurance, is a highly experienced individual contributor who applies advanced knowledge of quality assurance concepts and technical capabilities to drive uncompromised laboratory integrity and minimize risks.
Principal Engineer, Core Infrastructure KlaviyoPrincipal Engineer, Core InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑enabled platform: Approved AI tooling is integrated into IDE/CI/CD with repo policies and auditability; 70% MAU among eligible engineers; MTTR down 20-30% via AI‑assisted triage; flaky‑test rate decreases through targeted, AI‑suggested fixes.
Principal Software Engineer, Platform Engineering ModernaTXPrincipal Software Engineer, Platform EngineeringCambridge, MassachusettsThis is a senior individual contributor role that combines deep technical execution with cross-functional technical leadership across developers ("Builders"), Cybersecurity, Architecture, AI platform teams, and broader teams to provide scalable, secure, and user-focused capabilities that make the right path the easiest path for Moderna’s engineering teams. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Engineer, Data Infrastructure KlaviyoPrincipal Engineer, Data InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑augmented data operations: Semantic discovery and auto‑documentation cover the majority of high‑value datasets; AI‑assisted DQ monitors reduce data incidents on top pipelines by 25-40%; pipeline authoring and review times drop 15-25% with AI in the loop.
Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Principal Sales Engineer, SLED - East Zscaler IncPrincipal Sales Engineer, SLED - EastMARemote$175,875–$251,250 / yearThe range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations and could be higher or lower based on a multitude of factors, including job-related skills, experience, and relevant education or training. Demonstrated ability to act as a Consultative AI Advisor, guiding customers through AI change management, including mapping manual business workflows to agentic AI systems and managing expectations around non-deterministic outputs.
Principal Scientist, mRNA-tLNP Analytical Development Kernal BiologicsPrincipal Scientist, mRNA-tLNP Analytical DevelopmentBoston, MassachusettsDevelop and qualify methods to characterize antibody–lipid bioconjugates and targeted LNPs, including conjugation efficiency, antibody-to-particle ratio and surface ligand density, free/unconjugated antibody, conjugate identity and integrity, and antigen-binding activity. Demonstrated expertise in developing analytical methods to test and characterize mRNA and LNP products, spanning both biophysical and biochemical techniques (particle size measurement, HPLC, LC-MS, CE, ELISA, qPCR, protein analysis, and in vitro potency assays).
Principal Engineer, CMC Development Pilot Operations ModernaTXPrincipal Engineer, CMC Development Pilot OperationsNorwood, MassachusettsThe Principal Engineer will partner closely with CMC Dev Quality, analytical testing laboratories, Process Development, Engineering, Safety, Digital, and the GMP manufacturing facility to ensure seamless material delivery, technical readiness, operational excellence, and robust transfer of product and process knowledge across the manufacturing network. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Systems Engineer, Digital Lab Systems ModernaTXPrincipal Systems Engineer, Digital Lab SystemsNorwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team.
Investment Principal, Public Markets Partner's CapitalInvestment Principal, Public MarketsBoston, MassachusettsThe primary goal of the Public Markets Research Team is to deliver high absolute and relative returns over the long-term by partnering with of top-tier managers and select direct investments. In addition to the above, you will, for variety, take on other activities and projects, which might include researching and improving our portfolio construction knowledge and approach, assisting with business development, or helping to develop our technological capabilities.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal, Market & Reference Data Partner's CapitalPrincipal, Market & Reference DataBoston, MassachusettsThis is a hands-on leadership role at the center of the firm’s investment, operations, risk, and technology workflows which involves owning the integrity of reference data that powers trading, portfolio management, performance, valuation, and reporting firmwide. The role combines deep subject matter expertise in financial instrument and market reference data with strong commercial discipline and the relationship-building skills needed to operate as a trusted partner to functional leaders across the firm.
Client Service Principal, Taxable Partner's CapitalClient Service Principal, TaxableBoston, MassachusettsHands-on experience servicing US taxable clients (HNW families and family offices), including multi-entity household structures, tax-aware investment operations, and coordination with external CPAs and trust & estate counsel. Proactively identify and mitigate potential risks related to client accounts, working internally to identify, assess, and mitigate risks associated with client accounts and operational processes.
Principal Industrial Designer - US Kids2 LLCPrincipal Industrial Designer - USRhode Island, RIThis role requires a highly creative, strategic, and collaborative design leader who can guide projects from concept through production while partnering cross-functionally with Engineering, Marketing, Packaging, Product Management, and global manufacturing teams. The Principal Industrial Designer will also help elevate the design organization by mentoring junior designers, influencing creative direction, and contributing to the evolution of design processes, tools, and brand expression across the portfolio.
Principal Data Strategy Analyst Liberty Mutual Holding Company IncPrincipal Data Strategy AnalystBoston, MADescription As a Principal Data Strategist within the Office of Data and Data Science team supporting People, Purpose, and Brand, you will be a driving force behind transforming our organization and supporting business goals through cutting-edge data initiatives. You'll not only manage impactful data projects but also develop and mature strategy practices to steer an overall data strategy vision alongside our Enterprise Data Practice partners.
Principal Product Manager, Search Scribd, IncPrincipal Product Manager, SearchBoston, MASuccess here means defining a compelling vision, crafting metrics that truly matter, and experimenting your way to breakthrough features that redefine search relevance and discovery - all in close partnership with Engineering, Analytics, Data Science, Design, and Machine Learning teams who turn strategy into production reality. Familiarity with modern ML operations tooling - from vector databases to end-to-end model-ops workflows (MLOps / LLMOps) - and the ability to collaborate with engineering teams that rely on these systems.
Principal Systems Engineer Onto Innovation IncPrincipal Systems EngineerWilmington, MAOnto Innovation is a leader in process control, combining global scale with an expanded portfolio of leading-edge technologies that include: 3D metrology spanning the chip from nanometer-scale transistors to micron-level die-interconnects; macro defect inspection of wafers and packages; metal interconnect composition; factory analytics; and lithography for advanced semiconductor packaging. We are seeking a Principal Systems Engineer to provide technical leadership in the advancement of the existing platforms and the introduction of new complex automated optical inspection and metrology systems for the semiconductor industry.
Principal IT Systems Administrator CarGurus IncPrincipal IT Systems AdministratorBoston, MA$113,000–$142,000 / yearNice to have Experience in a high-growth SaaS or technology company familiarity with CarGurus tools Okta Google WorkspaceM365 Jamf Intune and experience partnering with Security Engineering and GRC. Come join us for the ride Role overview The Principal IT Systems Administrator is the most senior individual contributor on the IT Systems team setting technical direction for core platforms endpoints networks and security within IT Operations.
Principal Data Scientist - Gen AI Xometry IncPrincipal Data Scientist - Gen AIWaltham, MA$200,000–$230,000 / yearIn this role, you will serve as a technical leader, owning a 12 month technical roadmap, driving large-scale cross-functional ML and AI initiatives, and setting the long-term scientific direction for AI-driven solutions that enhance Xometry''s service offerings. Generative AI Development: Develop and deploy generative AI models and large language models (LLMs) for multimodal document processing, focusing on extracting structured data from technical drawings, purchasing orders, and other complex documents.