Senior Scientist, Process Development (I,II,III) CellaresSenior Scientist, Process Development (I,II,III)South San Francisco, CAPartnering with Cellares enables academics, biotechs, and pharma companies to accelerate drug development and scale out manufacturing, lower process failure rates, lower manufacturing costs, and meet global patient demand. The ideal candidate will be a highly organized technical leader and cross-functional collaborator with demonstrated expertise in developing robust autologous and allogeneic cell therapy processes.
Environmental Analyst (Permitting & Compliance) Mainspring Energy IncEnvironmental Analyst (Permitting & Compliance)Menlo Park, CAEnvironmental Analyst (Permitting & Compliance)Menlo Park, CALegal - Legal /Salary /HybridApply for this jobJob OverviewMainspring is seeking a highly motivated, business-minded Environmental Analyst to join our Environmental Permitting & Compliance team. In this role, you will own key environmental compliance workflows and data systems, drive continuous improvement through automation and tool development, and serve as a strategic partner to Operations, Sales, Project Delivery, and other cross-functional stakeholders.
Environmental Project Manager APTIMEnvironmental Project ManagerConcord, CA$130,000–$180,000 / yearThe Project Manager must demonstrate the following minimum qualifications and experience: + Managerial and/or technical experience in remediation services involving the release of hazardous materials, contaminants, or pollutants to the environment, including: + Radiological Sites. APTIM Federal Services, LLC is seeking a qualified Project Manager (PM) to manage and execute environmental remediation task orders in Northern California including the surrounding areas of San Francisco Bay and Sacramento.
Data Scientist, Knowledge Graphs MithrlData Scientist, Knowledge GraphsSan Francisco, CaliforniaThis role focuses on ingesting and harmonizing the world’s most important biological data sources and curating the relationships that allow our system to reason across pathways, targets, diseases, compounds, and multimodal datasets. Beyond ingestion and curation, you will create the tools and frameworks that allow users to interact with the knowledge graph and even build their own custom graphs based on the results they generate inside Mithrl.
Principal Scientist, Purification Process Development Denali Therapeutics IncPrincipal Scientist, Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Qualifications/Skills: Typically requires a PhD in Biology, Biochemistry, Chemical Engineering or related scientific discipline, plus 10+ years' of related work experience.
Senior Scientist, Characterization Denali Therapeutics IncSenior Scientist, CharacterizationSouth San Francisco, CA$147,000–$191,000 / yearIn depth knowledge and extensive hands-on experience developing and applying mass spectrometry-based methods (Intact/reduced MS, subunit analysis, peptide mapping, N-/O-glycosylation profiling, disulfide linkage determination, LC-MS/MS analysis) for protein sequence confirmation, identification and characterization of product variants, and comparability in the context of protein therapeutics. Qualifications/Skills: Typically requires a PhD in Analytical Chemistry, Chemical Engineering, Biophysics or related scientific discipline and 3+ years of direct CMC-focused analytical development experience in protein therapeutics within the biotech/biopharma industry (MS with 8+ or BS with 10+ years' experience).
Principal Scientist, Downstream Process Development (Contract) - AW Adverum Biotechnologies IncPrincipal Scientist, Downstream Process Development (Contract) - AWRedwood City, CA$80–$90 / hourThe successful candidate will participate in late-stage activities including design and optimization of the process as needed using historical batch data and manufacturing needs; process characterization; and tech-transfer of downstream processes to support clinical and commercial manufacturing. Leveraging the research capabilities of its proprietary intravitreal (IVT) platform, Adverum is developing durable, single-administration therapies designed to be delivered in physicians' offices to eliminate the need for frequent ocular injections to treat these diseases.
Principal Scientist, Purification Process Development Denali TherapeuticsPrincipal Scientist, Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearDenali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. Qualifications/Skills: Typically requires a PhD in Biology, Biochemistry, Chemical Engineering or related scientific discipline, plus 10+ years' of related work experience.
Associate Director, CMC Project Management ORIC Pharmaceuticals IncAssociate Director, CMC Project ManagementSouth San Francisco, CA$210,000–$240,000 / yearORIC's clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Working with functional leads (Drug Substance, Drug Product, and Analytical Department Heads), execute a robust external manufacturing strategy, including selection, onboarding, and management of CMOs/CDMOs.
Sr Research Associate Talent Software Services, Inc.Sr Research AssociateSan Rafael, CA$35–$43.75 / hourThe Therapeutics Process Development & Characterization (TPDC) group is seeking a highly motivated Temporary Senior Research Associate to support biologics purification and analytical characterization, with a primary focus on recombinant enzymes and additional exposure to therapeutic proteins, antibodies, and peptide-based modalities. Protein & Biologic Purification Independently perform purification of recombinant enzymes and other therapeutic biologics, including proteins, antibodies, and peptides, using ÄKTA Pure and ÄKTA Avant chromatography systems.
NewPrincipal Scientist, CMC Analytical Development - Commercial Products Denali Therapeutics IncPrincipal Scientist, CMC Analytical Development - Commercial ProductsSouth San Francisco, CA$159,000–$207,000 / yearAs the product transitions into routine commercial production and Denali pursues marketing applications in additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical Development Team to serve as a Commercial Analytical Lifecycle Lead. The Commercial Analytical Lifecycle Lead is expected to partner closely with peer Late Stage Analytical Development and Bioassay Development Leads responsible for driving successful analytical transfer & registration of a second-source manufacturing and QC site.
Senior Manager, Quality Control Vir Biotechnology, Inc.Senior Manager, Quality ControlSan Francisco, CA$142,500–$199,000 / yearThe Senior Manager, Technical Operations Quality Control, is responsible for executing and operationalizing QC strategy across assigned programs and external testing partners (e.g., CDMOs/CTLs) from Phase 1 through commercialization. The Senior Manager partners cross-functionally with Quality, Technical Operations, Regulatory, and Analytical Development to deliver program milestones, maintain inspection readiness, and support global regulatory submissions.
Senior Scientist, Large Molecule Characterization Denali TherapeuticsSenior Scientist, Large Molecule CharacterizationSouth San Francisco, CA$147,000–$191,000 / yearIn depth knowledge and extensive hands-on experience developing and applying mass spectrometry-based methods (Intact/reduced MS, subunit analysis, peptide mapping, N-/O-glycosylation profiling, disulfide linkage determination, LC-MS/MS analysis) for protein sequence confirmation, identification and characterization of product variants, and comparability in the context of protein therapeutics. Qualifications/Skills: Typically requires a PhD in Analytical Chemistry, Chemical Engineering, Biophysics or related scientific discipline and 3+ years of direct CMC-focused analytical development experience in protein therapeutics within the biotech/biopharma industry (MS with 8+ or BS with 10+ years' experience).
NewPrincipal Scientist, Commercial & Late-Stage Cell Culture Process Development Denali Therapeutics IncPrincipal Scientist, Commercial & Late-Stage Cell Culture Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearSupport lifecycle management activities for commercial products, including process improvements, tech transfer validation activities, local and cross-site change management, regulatory filing updates (CBE, PAS, Ex-US expansion), and responses to health authority questions. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
NewPrincipal Scientist, Commercial and Late-Stage Purification Process Development Denali Therapeutics IncPrincipal Scientist, Commercial and Late-Stage Purification Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearSupport lifecycle management activities for commercial products, including process improvements, tech transfer validation activities, local and cross-site change management, regulatory filing updates (CBE, PAS, Ex-US expansion), and responses to health authority questions. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
NewPrincipal Scientist, CMC Analytical Development - Commercial Products Denali TherapeuticsPrincipal Scientist, CMC Analytical Development - Commercial ProductsSouth San Francisco, CA$159,000–$207,000 / yearAs the product transitions into routine commercial production and Denali pursues marketing applications in additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical Development Team to serve as a Commercial Analytical Lifecycle Lead. The Commercial Analytical Lifecycle Lead is expected to partner closely with peer Late Stage Analytical Development and Bioassay Development Leads responsible for driving successful analytical transfer & registration of a second-source manufacturing and QC site.
NewPrincipal Scientist, Commercial & Late-Stage Cell Culture Process Development Denali TherapeuticsPrincipal Scientist, Commercial & Late-Stage Cell Culture Process DevelopmentSouth San Francisco, CA$159,000–$207,000 / yearSupport lifecycle management activities for commercial products, including process improvements, tech transfer validation activities, local and cross-site change management, regulatory filing updates (CBE, PAS, Ex-US expansion), and responses to health authority questions. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
Senior Manager, Commercial MSAT, Polysaccharide VaxcyteSenior Manager, Commercial MSAT, PolysaccharideSan Carlos, California$165,000–$193,000 / yearManufacturing Science and Technology (MSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. The range of activities will include technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle, etc.
NewSenior Manager, Commercial Msat, Polysaccharide VaxcyteSenior Manager, Commercial Msat, PolysaccharideSan Carlos, CA$165,000–$193,000 / yearManufacturing Science and Technology (MSAT) is responsible for successfully and seamlessly transitioning the vaccine process from Process Development to Commercial, developing and executing technical launch and commercialization strategy, continuously improving process robustness through to end of lifecycle, and ensuring best possible patient outcomes while creating value for the enterprise. The range of activities will include technology transfer support, process characterization experiments in support of validation, process improvement, evaluation of novel process technologies, investigation of process related manufacturing issues, ensuring continuous improvement in process robustness throughout the product life cycle, etc.
Sr. Assoc. Scientist, Process and Product Development (Contract) Allogene Therapeutics IncSr. Assoc. Scientist, Process and Product Development (Contract)South San Francisco, CA$45–$50 / hourAbout Allogene: Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of "off-the-shelf" CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients.