Senior Principal Hardware Design Engineer RTXSenior Principal Hardware Design EngineerTewksbury, MassachusettsThese design efforts will include collaboration with systems engineers, mechanical engineers, manufacturing engineers, and other electrical engineers to perform design trades and requirements flow down, perform electrical analysis, develop test plans, and ultimately to deliver working hardware that meets program requirements. Ability to obtain INTERIM U.S. government issued security clearance is required prior to start date At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems.
Principal Mechanical Engineer The Home Depot IncPrincipal Mechanical EngineerWaltham, MA$150,000–$200,000 / yearDrive Design for Manufacturing (DFM), Design for Assembly (DFA), Design for Serviceability (DFS), Design for Reliability (DFR), and cost optimization initiatives to ensure successful transition from development into production and long-term product support. This role will lead the architecture, design, and commercialization of innovative products from concept through production, while partnering across engineering disciplines and business functions to deliver reliable, manufacturable, and cost-effective solutions.
Presales Solution Principal in Supply Chain SaaS - Pricing & Promotions RELEX OyPresales Solution Principal in Supply Chain SaaS - Pricing & PromotionsBostonRemoteDetailed knowledge of pricing and promotion business logic, such as price optimization and rule frameworks, price elasticity and demand modeling, price zones and family/link rules, KVI and price image management, competitor price response, promotional lift and cannibalization, and post-event effectiveness analysis. RELEX Solutions offers an AI-native, unified supply chain and retail planning platform that helps retailers, wholesalers, manufacturers, and consumer packaged goods (CPG) companies plan, optimize, and automate operations across demand forecasting, inventory, merchandising, pricing, and supply chain management.
Principal Manufacturing Engineer, Assembly Amazon.com IncPrincipal Manufacturing Engineer, AssemblyNorth Reading, MAThis is a senior technical leadership role - you"ll create clarity from ambiguity, set manufacturing direction and architect production systems that maximize learning velocity while laying the groundwork for future high-volume scale. Amazon is seeking a Principal Manufacturing Engineer to define and drive the manufacturing strategy manufacturing strategy for new product introductions, informing production line design while partnering to design the product for manufacturing.
PATRIOT - Principal Program Cost Controls Analyst - P3 - (Hybrid) RTXPATRIOT - Principal Program Cost Controls Analyst - P3 - (Hybrid)Tewksbury, ArizonaNot Required At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. The successful candidate will serve as a Principal Program Cost Controls Analyst (P3), leading financial planning, analysis, and execution for the program while managing and developing a team of analysts.
Principal Network Engineer Zelis Healthcare, Inc.Principal Network EngineerBoston, MA$127,000–$160,550 / yearThe successful candidate will possess deep expertise in Palo Alto Networks Firewalls, Palo Alto Prisma SASE, AWS Networking, Cisco Routing & Switching, Network Security, Infrastructure Automation, and hybrid cloud connectivity solutions. As a Principal Network Engineer, you'll have the opportunity to influence enterprise-wide technology strategy and architecture decisions, lead modernization initiatives, partner with cloud, security, infrastructure, and application engineering teams, and mentor engineering talent across the organization.
Principal Specialist - Design Release Coordinator RTXPrincipal Specialist - Design Release CoordinatorTewksbury, MassachusettsWork in unison with each program Integrated Product Team Lead (IPTL), program engineering personnel (Hardware Engineers, drafting, Chief Engineers, etc.), Configuration Management for Configuration Control Boards (CCB) and Product Data Management (cPDM) coordination, Design Integrity Check, Computer-aided-design (CAD), etc. Ability to obtain INTERIM U.S. government issued security clearance is required prior to start date At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems.
Raven StealthCo - Principal Scientist, In Vivo Pharmacology RavenRaven StealthCo - Principal Scientist, In Vivo PharmacologyBoston, Massachusetts$170,000–$185,000 / yearThe team is small, the work deeply cross-functional, and priorities shift, so we want someone thoughtful, highly organized, and energized by a fast-paced start-up, with significant latitude to shape how we run in vivo pharmacology and a clear path to grow in scope and leadership as the organization matures. As one of our earliest and more senior hires, this person helps shape a culture we are deliberate about: rooted in psychological safety, where good ideas are welcomed from any seat, respect is paramount, failure is a chance to learn rather than a cause for blame, and mentorship is the spine of strong teams.
NewPrincipal Clinical Data Manager Alnylam Pharmaceuticals IncPrincipal Clinical Data ManagerCambridge, MA$147,900–$200,100 / yearCollaborate with internal and external partners, including Biostatistics, Statistical Programming, Clinical Operations, Clinical Research, Quality Assurance, Global Patient Safety and Risk Management, and Regulatory Affairs; CROs, central and local laboratories, and other vendors. Collaborate with Statistical Programming to oversee SDTM validation efforts, performing review of validation reports, SDTM Reviewer Guides and define.xml files, and coordinating feedback to CRO while driving internal decision-making and overseeing issues to resolution.
NewPrincipal Scientist, DMPK Alnylam Pharmaceuticals IncPrincipal Scientist, DMPKCambridge, MA$147,200–$220,800 / yearThe candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance programs from discovery through clinical development. Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership teams to integrate PK, PD, efficacy, safety, and biomarker data and inform development decisions.
NewPrincipal Systems Integration Engineer Elbit America, Inc.Principal Systems Integration EngineerMerrimack, NHFull timeAbility to interact professionally with a diverse group, including executives, managers, subject matter experts, and business users, as well as internal and external developers and technical service teams. The Principal Systems Integration Engineer is responsible for understanding and translating complex customer requirements into technical solutions, creating and managing development, integration, and testing solutions, and ensuring that all systems are properly integrated.
Principal Machine Learning Engineer Cambridge Mobile TelematicsPrincipal Machine Learning EngineerCambridge, MA$177,000–$221,300 / yearExperience building large-scale data processing and orchestration: Spark or Beam, Airflow, Kafka or Pub/Sub, Docker, and Kubernetes on AWS, GCP, or Azure. Recognized innovator in mobility AI, earning top honors including the TIME Industry Leader in AI, a Gold Edison Award, and the Artificial Intelligence Excellence Award for AI for Social Good.
Associate Principal, Monitoring, Evaluation And Quality Improvement (Meqi) BME StrategiesAssociate Principal, Monitoring, Evaluation And Quality Improvement (Meqi)North Andover, MA$99,840–$162,240 / yearThis may include rural health evaluation design and implementation, multi-site evaluation architecture, performance measurement for complex public health initiatives, public health data strategy, health information exchange (HIE) integration, data governance, and capacity-building for public health agencies navigating a rapidly changing data landscape. What is consistent across strong candidates is a track record of leading complex engagements at the state level; managing and developing staff; holding client relationships with sophistication and commercial awareness; and contributing to business development with the credibility of someone who has delivered at scale.
Process Engineer, Principal Scientist - Automation of Machinery and Processes Vertex Pharmaceuticals IncProcess Engineer, Principal Scientist - Automation of Machinery and ProcessesBoston, MA$141,800–$212,800 / yearTechnical Delivery: Lead major engineering workstreams and complex equipment development efforts from concept through implementation, including URS/FRS development, technology evaluations, RFP and vendor selection, facility & systems simulation, requirements mapping, safety risk assessments, FMEA execution, study design, FAT/SAT execution, technology transfer, and validation support. Cross-Functional Influence and Collaboration: Partner closely with Manufacturing, Process Development, Quality, Validation, Facilities, MSAT, Project Management, and external vendors/partners to ensure successful delivery of engineering and equipment initiatives across the product lifecycle.
Principal Product Designer VIAPrincipal Product DesignerSomerville, MassachusettsRemote$160,000–$190,000 / yearAgentic and collaborative workflow experience: You've navigated UX problems where multiple users or multiple agents interact with shared state, and you know how to make those flows feel clear, not chaotic. Own end-to-end UX/UI design across VIA's product suite, including AI-native platforms, agentic workflow interfaces, multiplayer and collaborative data environments, and permission-controlled data sharing experiences.
Principal Machine Learning Operations Engineer Definitive Healthcare, USPrincipal Machine Learning Operations EngineerFramingham, MA$158,000–$294,000 / yearIn 2024 and 2025, we earned multiple workplace honors, including Built In’s 100 Best Places to Work in Boston (both years), a Stevie Bronze Award for Great Employers, and recognition as a Great Place to Work in India. As the Functional Lead, you will drive engineering excellence, establish MLOps best practices across the organization, mentor senior engineers, and translate strategic business objectives into robust, highly scalable automated pipelines.
Associate Principal/Ediscovery (Forensic Services) CRA International, Inc.Associate Principal/Ediscovery (Forensic Services)Boston, MA$140,000–$170,000 / yearYour responsibilities may include (but are not limited to): Executing on projects involving the identification, collection, processing, review, and production of data relevant to litigation or regulatory investigations; Supporting engagement planning - participating in project team execution, analysis, and work product; Interfacing with client personnel and implementing client discovery strategies; Preparing client communications/reports for project milestones and senior leadership; Implementing client data processing projects, including planning of processing specifications, search parameters, etc. Ability to effectively lead teams, prioritize multiple projects, design workflows, and meet timely deadlines; Strong policy, process and project management experience, including management of multiple simultaneous workflows and team members; Excellent analytical, decision making and problem-solving skills; Ability to influence colleagues and implement initiatives across functions; Demonstrates integrity, initiative and commitment in all interactions with colleagues and clients.
Principal Scientist R&D & Cgmp Preparative Chromatography Vertex Pharmaceuticals, IncPrincipal Scientist R&D & Cgmp Preparative ChromatographyBoston, MA$138,000–$207,000 / yearThis is an exceptional opportunity for a seasoned pharmaceutical scientist with deep expertise in analytical and preparative chromatographic purification in both an R&D and cGMP environment- including large-scale preparative HPLC, supercritical fluid chromatography (SFC), Ion-pair reversed phase high-performance liquid chromatography (IP-RP_HPLC), ion exchange chromatography (AEX/CEX), and size exclusion chromatography (SEC). Build Peptide and Oligonucleotide Purification Capability: Define the strategic roadmap and lead the implementation of kilogram oligonucleotide synthesis (solid-phase phosphoramidite chemistry) and purification platforms (IP-RP HPLC, AEX/CEX, ultrafiltration/diafiltration), including equipment procurement, qualification, and SOP establishment.
NewPrincipal Radar Systems Engineer RTXPrincipal Radar Systems EngineerConcord, MassachusettsRTX considers several factors when extending an offer, including but not limited to, the role, function and associated responsibilities, a candidate’s work experience, location, education/training, and key skills. As part of our commitment to maintaining a secure hiring process, candidates may be asked to attend select steps of the interview process in-person at one of our office locations, regardless of whether the role is designated as on-site, hybrid or remote.
NewSenior Principal Actuation Systems Leader RTXSenior Principal Actuation Systems LeaderTewksbury, MassachusettsThe ideal candidate possesses a combination of project / team leadership, design, product and production support experience, electronics knowledge, & hands-on laboratory skills, and is also a recognized Subject Matter Expert (SME) in areas related to actuation systems, motion control, motor drive systems, motor control, and/or electric machine design. You will be expected to apply sound systems engineering principles to define and solve sometimes complex actuation system problems while influencing engineering teams to include electrical engineering, mechanical engineering, control systems engineering, software and firmware engineering, manufacturing engineering, supply chain and others.