Reviewing trial-level ADI/RAID logs, Quality Plans, and readouts from quality metric dashboards (e.g., protocol deviations, temperature excursions), and proactively identifying and minimizing operational risks across the program/disease area/asset (e.g., clinical supply disruptions, service provider performance issues), escalating issues to CST and PDT as needed. Providing operational input at the CST level during protocol design (e.g., feasibility, execution risk, operational implications of design choices) and on program-level development planning documents (e.g., Clinical Development Plan, Protocol Concept Sheet, Protocol), ensuring program-level consistency and delivery of program objectives.