Principal Medical Writer CSL Behring LLCPrincipal Medical WriterKing of Prussia, PAHe or she is also responsible for the messaging strategy across a program of work, for the provision of strategic input into the development of clinical development plans and submission plans, and for analyzing proposed plans, programs, individual studies and related documents for their ability to deliver the information required by the target audience (ie, regulatory authority) in a compelling fashion with accuracy and consistency. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
Associate Principal Scientist, Downstream Bioprocess Modeling, Digital Insights Merck & Co IncAssociate Principal Scientist, Downstream Bioprocess Modeling, Digital InsightsWest Point, PA$142,400–$224,100 / yearRequired Skills: Analytical Testing, Analytical Testing, Biochemistry, Cell Line Development, Chemical Engineering, Computer Simulations, Data Modeling Techniques, Detail-Oriented, Downstream Process Development, Downstream Processing, Drug Delivery Technology, Drug Development, Expression Vectors, Interpersonal Relationships, Kinetics, Laboratory Instrumentation, Leading Project Teams, Method Development, Model Development, Model Driven Design, Molecular Biology, Parameter Estimation, Perform Testing, Pharmaceutical Formulations, Pharmaceutical Process Development {+ 9 more}. The successful candidate will play a technical leadership role in embedding mechanistic downstream modeling into DSCS decision-making-partnering closely with DSP scientists, process engineers, and DS technical leads to translate model outputs into actionable purification and manufacturing decisions.
Principal Scientist, Process Modeling, Digital Insights Merck & Co IncPrincipal Scientist, Process Modeling, Digital InsightsWest Point, PA$173,200–$272,600 / yearThe successful candidate will play a technical leadership role in establishing engineering simulation as a core capability across DSCS partnering deeply with experimentalists, process engineers, and DS technical leads to translate first-principles model outputs into actionable CMC decisions. In this Principal Scientist role, the successful candidate will apply first-principles engineering, computational fluid dynamics (CFD), and physics-based simulation to bring predictive rigor to scale-up across a multi-modality pipeline from small to large molecules, with a current focus on biologics.
Principal Scientist/Director (Downstream), Biologics Drug Substance Commercialization (BDSC) Merck & Co IncPrincipal Scientist/Director (Downstream), Biologics Drug Substance Commercialization (BDSC)West Point, PA$173,200–$272,600 / yearRequired Skills: Biological Engineering, Biologics, Biopharmaceutical Manufacturing, Bioproduction, Bioproducts, Chemical Engineering, Commercialization, Cross-Functional Teamwork, Decision Making, Downstream Processing, Drug Development, Manufacturing Scale-Up, Process Characterization, Process Development (PD), Process Transfers, Purification Methods, Strategic Thinking, Technology Transfer. The Principal Scientist (Director level) position in BDSC-Downstream team is a senior scientific and people leadership role supporting late stage and commercial biologics programs, with a primary focus on biologics downstream processing.
Principal Scientist, Translational Medicine, Neuroscience Merck & Co IncPrincipal Scientist, Translational Medicine, NeuroscienceWest Point, PA$255,800–$402,700 / yearPrimary responsibilities for the Principal Scientist include the following: Working with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets, including the design of preclinical and clinical experiments to validate targets and/or pathways, and leveraging this work for development of novel therapeutics. Translational Medicine is specifically responsible for: Contributing to the identification of novel targets by partnering with Discovery Sciences to bring a clinical perspective into the earliest stages of target identification and validation, and to execute clinical studies to evaluate the relevance of potential targets to human disease in order to justify full development.
Principal Enterprise Architect - Remote CSAA Insurance GroupPrincipal Enterprise Architect - RemotePARemote$186,660–$207,400 / yearAlabama - Home Teleworkers, Alabama - Home Teleworkers, Arkansas - Home Teleworkers, California - Home Teleworkers, Colorado - Home Teleworkers, Connecticut - Home Teleworkers, Delaware - Home Teleworker, District of Columbia - Home Teleworkers, Florida - Home Teleworkers, Georgia - Home Teleworkers, Idaho - Home Teleworkers, Illinois - Home Teleworkers, Indiana - Home Teleworkers, Iowa - Home Teleworkers, Kansas - Home Teleworker, Kentucky - Home Teleworkers, Louisiana - Home Teleworkers, Maine Home Teleworkers, Maryland - Home Teleworkers, Massachusetts - Home Teleworkers, Michigan - Home Teleworkers, Minnesota - Home Teleworkers, Mississippi - Home Teleworker, Missouri - Home Teleworker, Montana - Home Teleworkers {+ 21 more}. Experience designing and securing on-premises or hybrid AI infrastructure, including GPU-accelerated compute, private AI/ML platforms, model hosting environments, data pipelines, and supporting network, identity, storage, and workload security controls.
NewPrincipal Scientist (Director), Clinical Research, Immunology Merck & Co IncPrincipal Scientist (Director), Clinical Research, Immunologyupper gwynedd, PA$255,800–$402,700 / yearWork closely with a cross-functional group of experts in commercialization, regulatory affairs, statistics, and manufacturing to manage clinical development projects; and assist the Senior Director, Associate Vice-President/Vice-President and Product Development Team Lead in ensuring that appropriate corporate personnel is informed of the progress of studies of our company and competitors' drugs and internal and external expert opinion on scientific questions relevant to his/her areas of responsibility. With a focus on late-stage development, the Clinical Director will manage the entire cycle of clinical development, including determination of appropriate disease indications to pursue and subsequent study design, initiation, execution, monitoring, analysis, regulatory filing, and publication.
NewAssociate Principal Scientist, Engineering - Vaccine, Sterile Drug Product Commercialization Merck & Co IncAssociate Principal Scientist, Engineering - Vaccine, Sterile Drug Product CommercializationWest Point, PA$142,400–$224,100 / yearRequired Skills: Biochemistry, Biological Engineering, Biologics, Biopharmaceuticals, Bioprocess Engineering, Bioprocessing, Biotechnology, Chemical Engineering, Commercialization, Decision Making, Drug Product Manufacturing, Manufacturing Scale-Up, Process Improvements, Process Scale Up, Process Transfers, Protein Purifications, Regulatory Submissions, Shop Floor Management, Technical Writing, Technology Transfer, Vaccine Development, Virus Production. As part of Our Company's Manufacturing Division, the Sterile Drug Product Commercialization group provides the technical process leadership and laboratory capabilities for late stage and commercial drug product processes for vaccines, biologics, and sterile pharmaceutical products.
Insights and Analytics Principal, Large Pharma IQVIAInsights and Analytics Principal, Large PharmaWayne, PennsylvaniaLeveraging deep industry knowledge and strong client relationships, this role combines commercial acumen, data-driven problem solving, and thought leadership to help clients address complex brand and market challenges. The Insights and Analytics Principal is a senior analytics leader responsible for driving business growth, shaping analytic solutions, and delivering strategic insights that create measurable impact for our biopharma clients.
Senior Principal Scientist, Clinical Research, Thoracic Malignancies Merck & Co IncSenior Principal Scientist, Clinical Research, Thoracic MalignanciesNorth Wales, PA$282,200–$444,200 / yearMonitoring and managing the conduct of ongoing or new clinical trials for investigational or marketed Oncology drugs; Analyzing and summarizing the clinical findings from studies to support decisions regarding safety and efficacy as well as new drug applications, clinical study reports, or publication; and. Assist the Senior/Executive Director in ensuring that appropriate corporate personnel are informed of the progress of studies of our Company's and competitors' drugs and internal and external expert opinion on scientific questions relevant to his/her areas of responsibility.
NewPrincipal Scientist (Director), Translational Medicine - Cardiovascular Merck & Co IncPrincipal Scientist (Director), Translational Medicine - CardiovascularWest Point, PA$260,300–$409,700 / yearInterface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late-stage Clinical Research throughout research sites around the world. Contributing to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into the earliest stages of target identification and validation, and executing clinical studies to evaluate the relevance of potential targets to human disease in order to justify investment in clinical development programs.
Associate Principal Scientist/Engineer, Medical Device and Combination Products, ISO/DV Testing Manager Merck & Co IncAssociate Principal Scientist/Engineer, Medical Device and Combination Products, ISO/DV Testing ManagerWest Point, PA$142,400–$224,100 / yearResponsibilities will include: (1) strategic and tactical (day-to-day) management of design verification testing to support our commercial products to meet critical project timelines, (2) technical oversight of method development, validation, and implementation of analytical methods and associated investigational support at both internal and external laboratories, (3) ensuring safety, environmental and cGMP and ISO 13485 compliance for all laboratory activities and operations, (4) collaborating with CPDA program leads to drive test method development, validation and implementation of new instrumentation/analytical technologies for the laboratory to support current and future commercial MDCP DV testing, and, (5) oversight and technical coaching of CPDA analysts in the ISO laboratory. The Center for Packaging & Device Analytics (CPDA), within our Manufacturing Division, has responsibility for applied physical, material & analytical science to support production and commercialization of product packaging and drug-delivery medical device/combination-products (MDCPs), such as auto-injectors and pre-filled syringes.
NewPrincipal Scientist, Translational Clinical Biomarkers Merck & Co IncPrincipal Scientist, Translational Clinical Biomarkersupper gwynedd, PA$190,800–$300,300 / yearFor cardiovascular and metabolic programs, develop biomarker strategies addressing areas such as target engagement, pathway modulation, disease biology, pharmacodynamic response, patient heterogeneity, and relationships between biological effects and clinical outcomes. The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity, dose and regimen selection, clinical endpoints, and opportunities for precision medicine.
Principal Sales Engineer, SLED - East Zscaler IncPrincipal Sales Engineer, SLED - EastPARemote$175,875–$251,250 / yearThe range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations and could be higher or lower based on a multitude of factors, including job-related skills, experience, and relevant education or training. Demonstrated ability to act as a Consultative AI Advisor, guiding customers through AI change management, including mapping manual business workflows to agentic AI systems and managing expectations around non-deterministic outputs.
Associate Principal - Industry Advisory 3 GenpactAssociate Principal - Industry Advisory 3New JerseyArtificial Intelligence (AI), Artificial Intelligence (AI), Banking Capital Markets, Bank Risk Management, Business Banking, Business Consulting, Client Relations, Commercial Modeling, Critical Thinking, Electronic Hardware, Executive Presence, Fast Moving Consumer Goods, Food And Beverage (F&B), Generative AI, Hospitality, Industrial Manufacturing Processes, Insurance, Life Science, Media And Communications, Pharmaceutical Industry, Property & Casualty Insurance, Retail Banking, Retail Banking Products, Risk Analytics, Semiconductors {+ 3 more} Language . Certified Business Analysis Professional (CBAP) - UpgradUpgrad, Microsoft Certified: Power BI Data Analyst Associate - MicrosoftMicrosoft, PRINCE2 Practitioner - PeopleCraftPeopleCraft, Project Management Professional (PMP) - Virtual Learning Academy (VLA)Virtual Learning Academy (VLA), Tableau Desktop Specialist - EdurekaEdureka Required Skills .
SAP S/4 MRP Application Architect (Principal) Yantran LLCSAP S/4 MRP Application Architect (Principal)NEWTOWN SQUARE, PAThese roles require close collaboration with supply chain stakeholders during on-site workshops, along with remote configuration and documentation activities. Travel required for discovery sessions, process workshops, integration testing, and pilot deployment.
Principal Software Engineer Zuven technologies IncPrincipal Software EngineerBlue Bell, PALead the design and delivery of scalable microservices using Java and Spring Boot, ensuring clean separation of concerns and resilience. ? Architect and maintain Kafka-based event-streaming pipelines for real-time data processing and decoupled service communication. ?
Principal Data Engineer GTT, LLCPrincipal Data EngineerPhiladelphia, PAThe Principal Data Engineer will own the design, delivery, and maturity of production-grade data pipelines and data platforms, with a primary emphasis on real-time streaming, IoT telemetry, Databricks, Azure, data services for APIs and microservices, and reliable data products for downstream consumption. The ideal candidate should be comfortable spending significant time working directly with Databricks, Spark, SQL, Python/PySpark, Azure services, streaming architectures, data quality frameworks, pipeline automation, CI/CD, and production troubleshooting.
Principal, General Servicing Lakeview Loan ServicingPrincipal, General ServicingHorsham, PennsylvaniaRemote$128,000–$145,000 / yearFull timeReporting to the Director of Servicing Product, this role operates within the broader servicing product structure and brings shared-services domain expertise into requirements definition, workflow validation, testing support, and implementation discussions to ensure that platform functionality accurately reflects real-world servicing operations, regulatory expectations, and vendor dependencies. Instead, this position is designed for a deeply experienced servicing subject matter expert who understands, in detail, how shared servicing infrastructure enables consistent execution across borrower communications, vendor interactions, and cross-domain workflows, and can translate that expertise into scalable product capabilities.
Managing Principal HDR IncManaging PrincipalPhiladelphia, PAUnited States-Pennsylvania-Philadelphia'',''United States-Pennsylvania-Philadelphia'','''','''','''','''','''','''','''','''',''Architecture'',''Architecture'',''Full-time'',''Full-time'',''Regular'',''Regular'','''','''',''Gen Architecture'',''Gen Architecture'',''Apr 22, 2026'',''Apr 22, 2026'',''false'',''781593'',''781593'',''true'',''781593'',''false'',''Submission for the position: Managing Principal - (Job Number: 192608)'',''false'',''781593'',''false'',''true''. This individual will oversee and direct the activities of personnel within the office including implementing annual plans, marketing strategies, public relations, project planning, financial planning and management, staff planning and oversight and other related matters.