Principal Scientist SanofiPrincipal ScientistWaltham, MA$122.25–$176.58 / hourThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Main responsibilities: Lead scale-up activities from bench scale to pilot scale (200L-2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Principal Scientist, In Vivo Pharmacology, Oncology Merck & Co IncPrincipal Scientist, In Vivo Pharmacology, OncologyBoston, MA$176,200–$277,300 / yearRequired Skills: Cancer Research, Drug Discovery Process, Immunoassays, Immunohistochemistry (IHC), In Vivo Models, Leading Project Teams, Mass Spectrometry Imaging, Molecular Biology Techniques, Mouse Models, Multiplex Assays, Oncology, Pharmacokinetics, Pharmacology, Tumor Biology. The role will involve building alliances with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies (e.g., spatial biology using novel multi-plex immunohistochemistry capabilities), and interfacing with our global pharmacology network.
Senior Research Scientist, Robotics Research Toyota Research InstituteSenior Research Scientist, Robotics ResearchCambridge, MA$180,000–$258,750 / yearBackground or familiarity with some of the following: motion control and actuation, whole-body control, reinforcement learning, robot teleoperation methods, common communication protocols, research robotic arms/systems, visual perception and depth sensors, machine learning, robotic simulation, force and tactile sensing systems, haptic interfaces. A strong track record of impact, either via first author research publications at top-tier machine learning or robotics conferences (RSS, NeurIPS, ICML, CoRL, ICRA, IROS, …), or via meaningful contributions to successful industry initiatives.
NewSenior Scientist, Translational Data Science AstraZeneca PlcSenior Scientist, Translational Data ScienceCambridge, MA$115,057.60–$178,586.40 / yearExcellent coding skills in Python, R, or similar languages appropriate for large-scale omics analysis, together with experience in version control such as Git/Bitbucket, Linux environments (cluster and/or cloud), and effective use of modern AI-assisted coding tools such as GitHub Copilot or Claude Code. In this role, you will work in a highly collaborative and science-driven environment focused on advancing our understanding of immune-mediated disease biology, identifying novel therapeutic opportunities, and enabling precision approaches across our Immunology portfolio from discovery through clinical development.
(StealthCo) Scientist: Biology and Cell Pharmacology Foresite Labs(StealthCo) Scientist: Biology and Cell PharmacologyBoston, MAThe position is a rare opportunity to play a pivotal role in the successful development of new drugs for patients within an early-stage therapeutics company backed by highly regarded investors. The successful candidate will be mechanistically minded, able to connect experimental observations to underlying biology, build novel reproducible assays, and deliver results in a fast-paced environment.
Research Leader / Senior Scientist Medicinal Drug Design, Cambridge, MA Isomorphic Labs LimitedResearch Leader / Senior Scientist Medicinal Drug Design, Cambridge, MACambridge, MAProven track record of project leadership / leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation or candidate nomination), with familiarity of optimisation of ADME properties. Rapidly drive drug discovery programs to value inflection points by deploying your knowledge of modern discovery principles and synthetic organic chemistry, taking ownership as either an overall Project Lead or Medicinal Chemistry Lead.
Sr. Data Scientist - AI Voice LumerisSr. Data Scientist - AI VoiceMassachusettsRemoteReporting directly to our VP of AI, you'll split your time between two halves of the same problem: developing and fine-tuning the models that power clinical AI, and building the voice systems that let us test, stress, and trust those models before they ever reach a patient. Must-have hands-on experience building and deploying production voice or conversational AI systems — speech and speech-to-speech, working with real audio in live environments, not text-only NLP or chat.
Principal Scientist, TCR Optimization ModernaTXPrincipal Scientist, TCR OptimizationCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. The role is well suited for a hands-on scientist who can execute complex experimental workflows, interpret multi-parameter datasets, and contribute to the generation of optimized TCR candidates with the potency, specificity, and developability required for therapeutic advancement.
Principal Scientist, DMPK Merck & Co IncPrincipal Scientist, DMPKBoston, MA$176,200–$277,300 / yearRequired Skills: ADME, Bioanalytical Method Development, Biologics, Cross-Functional Teamwork, DMPK, Drug Metabolism, Immunoassays, Immunology, In Vitro Studies, Mentoring Staff, Oncology, Peptides, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics, PKPD Modeling. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities such as peptides and protein therapeutics as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division.
NewSenior Scientist, Biologics Process Analytical Method Development 3316 Takeda Development Center AmericasSenior Scientist, Biologics Process Analytical Method DevelopmentLexington, MassachusettsThe actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. Develop, optimize, transfer, and sustain high-throughput, fit-for-purpose analytical methods for biologics development using phase-appropriate approaches and Analytical Quality by Design (AQbD) principles.
Scientist, Platform RNA Sciences Senda BiosciencesScientist, Platform RNA SciencesCambridge, MA$98,000–$125,000 / yearStrong background in RNA biology with demonstrated skillset in relevant molecular and biochemical techniques, such as in vitro transcription (IVT), RNA purification, oligo-dT purification, column chromatography, capillary gel electrophoresis, RT-qPCR, RNA-seq, Nanopore sequencing. This role works cross-functionally to perform hypothesis-driven experiments and high-throughput screens to improve our eRNA designs, with the goal to maximize circularization, and enhance RNA stability and translation.
Principal Scientist (Scientific Director Level)- Nonclinical Drug Safety Merck & Co IncPrincipal Scientist (Scientific Director Level)- Nonclinical Drug SafetyBoston, MA$176,200–$277,300 / yearThey are responsible for 1) providing risk assessments for targets, 2) de-risking strategies for discovery programs and 3) collaborating with NDS staff at other sites to execute on the appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates. The Discovery Program Leader is responsible for defining and overseeing the NDS strategy for programs in all modalities (including small molecules, peptides, biologics and ADC programs) from Target Identification through to the approval of First-In-Human enabling GLP toxicity studies.
Senior Associate Scientist, In Vitro Biology and Mechanism of Action SanofiSenior Associate Scientist, In Vitro Biology and Mechanism of ActionWaltham, MA$75–$108.33 / hourMain Responsibilities: Lead from the bench to support the pre-clinical research of Sanofi's next generation RNA platform and support programs by designing and executing experiments targeted toward elucidating the mechanism of action for RNA vaccines and therapeutics. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Senior Scientist, Microbiology Lead Terrestrial Bio IncSenior Scientist, Microbiology LeadWoburn, MA$130,000–$160,000 / yearThis individual will build the microbiology function from the ground up including Bioburden, Bacterial Endotoxin (BET), and Environmental Monitoring (EM) capabilities and ensure the lab is fully operational and qualified to support Tox manufacturing and Phase 3 clinical supply. We are seeking an experienced Microbiology Lead to establish and lead our in-house GMP Microbiology laboratory supporting the microneedle array patch (MAP) program from Phase 2 through commercialization.
Research Leader / Senior Scientist Computational Drug Design, Cambridge, MA Isomorphic Labs LimitedResearch Leader / Senior Scientist Computational Drug Design, Cambridge, MACambridge, MAProven track record of project leadership / leading computational chemistry efforts on drug discovery programs, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation or candidate nomination). By harnessing AI's powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world's most devastating diseases.
Senior Associate Scientist Bioprocess Analytics SanofiSenior Associate Scientist Bioprocess AnalyticsFramingham, MA$75–$108.33 / hourMain Responsibilities: Provide analytical support for Process Science, R&D, Manufacturing, and cross-functional partners by independently executing routine and advanced analytical testing using HPLC/UPLC, CE, cIEF, ELISA, binding assays, impurity analysis, and LC-MS/MS peptide mapping in a non-GMP environment to advance biologics development programs and achieve project milestones. Preferred Qualifications: Strong expertise in protein characterization, including purity, charge variant, and glycan analyses, with extensive hands-on experience in operation, troubleshooting, and maintenance of Waters and Agilent HPLC/UHPLC systems, Caliper LabChips, PA800 Plus, Maurice/iCE, and BioPhase 8800 platforms.
New2027 Spring Co op CMC Synthetics Platform Process and Pharmaceutical Engineering Scientist Cambridge MA Sanofi2027 Spring Co op CMC Synthetics Platform Process and Pharmaceutical Engineering Scientist Cambridge MACambridge, MA$45–$57 / hourThe successful candidate will work on projects spanning single crystal property prediction, powder compaction simulation, and experimental analysis of tablet mechanical failure using digital image correlation (DIC). Students currently on CPT, OPT, or STEM OPT usually require future sponsorship for long term employment and do not meet the requirements for this program unless eligible for an alternative long-term status that does not require company sponsorship.
NewScientist, Early Formulation GSK plcScientist, Early FormulationCambridge, MA$89,925–$149,875 / yearThis hands-on, laboratory-based role focuses on designing and executing formulation and stability studies, characterizing physicochemical properties, and generating in vitro and in vivo assessment data that inform antigen design, lead selection, and portfolio decision-making across multiple vaccine modalities. Biotechnology, Cell Biology, Cross-Functional Teamwork, Data Quality, Following Instructions, Interpersonal Communication, Lab Maintenance, Life Science, Matrix Leadership, Proper Documentation, Scientific Presentations, Scientific Research, Scientific Writing.
Sr. Scientist, Neuroscience Biomarker Discovery - Biomarker Mechanisms Merck & Co IncSr. Scientist, Neuroscience Biomarker Discovery - Biomarker MechanismsBoston, MA$117,000–$184,200 / yearRequired Skills: Assay Development, Biochemical Assays, Biomarkers, Biomedical Research, Cell Culture Techniques, Disease Models, Disease Research, Flow Cytometry, High Content Screening, In Vivo Models, Mechanism of Action, Molecular Biology, Neurodegeneration, Neuroscience, Omics, Organoid Culture, Pharmaceutical Translations, Preclinical Research, Protein Purifications, Signaling Pathways, Teamwork, Transcriptomics. Primary Responsibilities: Design and execute targeted perturbation studies using human in vitro systems and (e.g., hiPSC-derived neurons, astrocytes, microglia or complex organoids) collaborate on in vivo preclinical models to map the causal biological cascade from target engagement to downstream biomarker responses.
Sr. Scientist, Assay Development - Neuroscience Biomarker Discovery Merck & Co IncSr. Scientist, Assay Development - Neuroscience Biomarker DiscoveryBoston, MA$106,200–$167,200 / yearRequired Skills: Assay Development, Bioassay Development, Biomarker Development, Biomarker Discovery, Biomarker Identification, Biomarkers, Disease Models, Drug Discovery Research, Flow Cytometry, High-Throughput Screening, Immunoassays, In Vitro Assays, In Vivo Models, Molecular Biology Techniques, Neurodegeneration, Next Generation Sequencing (NGS), Omics, Preclinical Research, Protein Purifications, RNA-Seq, Scientific Writing. Required Qualifications: Master's in molecular biology, Biochemistry, Neuroscience, Immunology, Neurology, or related STEM fields with minimum 6 years of relevant industry experience OR PhD in molecular biology, Biochemistry, Neuroscience, Immunology, Neurology, or related STEM fields with hands-on relevant experience.