Ensure compliance and validation of GxP-impacting computerized systems, including review and approval of validation deliverables such as risk assessments, validation plans, specifications, test protocols and results, SOPs, security, backup, archival, change control, incident management, periodic review, retirement, user access, and audit trail review documentation. Lead and support Operational Excellence and Continuous Improvement initiatives using Lean Manufacturing and Six Sigma principles, including cost reduction projects, KPI monitoring, root cause investigation support, visual management, best practice implementation, and productivity and quality improvements.