Clinical Research, Senior Principal Scientist (Director), Oncology Lantheus Holdings IncClinical Research, Senior Principal Scientist (Director), OncologyBedford, MA$172,000–$287,000 / yearProvide scientific leadership to cross-functional teams spanning Clinical Operations, Imaging Sciences and Operations, Biostatistics, Regulatory Affairs, Medical Affairs, Pharmacovigilance, CMC, Translational Sciences and external partners. The role shapes clinical research strategy and leads the scientific design, execution, interpretation and communication of company-sponsored clinical research, with particular emphasis on diagnostic imaging, radiopharmaceuticals and molecular imaging.
Principal Scientist, In Vivo Pharmacology, Oncology Merck & Co IncPrincipal Scientist, In Vivo Pharmacology, OncologyBoston, MA$176,200–$277,300 / yearRequired Skills: Cancer Research, Drug Discovery Process, Immunoassays, Immunohistochemistry (IHC), In Vivo Models, Leading Project Teams, Mass Spectrometry Imaging, Molecular Biology Techniques, Mouse Models, Multiplex Assays, Oncology, Pharmacokinetics, Pharmacology, Tumor Biology. The role will involve building alliances with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies (e.g., spatial biology using novel multi-plex immunohistochemistry capabilities), and interfacing with our global pharmacology network.
Principal Software Engineer Xometry IncPrincipal Software EngineerWaltham, MA$200,000–$225,000 / yearXometry's digital marketplace gives manufacturers the critical resources they need to grow their business while also making it easy for buyers at Fortune 1000 companies to tap into global manufacturing capacity. Operational Excellence: You will own the reliability and security of the integration microservices, ensuring that "click-to-buy" functionality is bulletproof and that monitoring/alerting covers the unique lifecycle of enterprise PLM transactions.
Principal Engineer (Control Systems) Fresenius Kabi AGPrincipal Engineer (Control Systems)North Andover, MA$115,000–$135,000 / yearThis experienced engineering position, under minimal supervision, participates in designing, coding, documenting, testing and maintenance of real-time embedded software and accessory software products. 3+ years of experience working with MATLAB and Simulink; experience with Simulink Coder, Stateflow, Simscape, Visual State or Quantum Leaps a plus.
Principal DevOps Engineer Evolv Technologies IncPrincipal DevOps EngineerWaltham, MA$137,000–$220,000 / yearIn accordance with state and local pay transparency laws-including those in California, Colorado, Massachusetts, New York, New Jersey, and others-we disclose salary ranges in all job postings and provide additional information upon request. In this role, you will partner closely with Platform, Security, Compliance, and Engineering teams to enable reliable, audit-ready cloud environments while balancing velocity, security, and operational excellence.
Principal Scientist, TCR Optimization ModernaTXPrincipal Scientist, TCR OptimizationCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. The role is well suited for a hands-on scientist who can execute complex experimental workflows, interpret multi-parameter datasets, and contribute to the generation of optimized TCR candidates with the potency, specificity, and developability required for therapeutic advancement.
Principal Scientist, Computational Protein Design ModernaTXPrincipal Scientist, Computational Protein DesignCambridge, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna’s Research and Early Development portfolio.
Principal Scientist, DMPK Merck & Co IncPrincipal Scientist, DMPKBoston, MA$176,200–$277,300 / yearRequired Skills: ADME, Bioanalytical Method Development, Biologics, Cross-Functional Teamwork, DMPK, Drug Metabolism, Immunoassays, Immunology, In Vitro Studies, Mentoring Staff, Oncology, Peptides, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics, PKPD Modeling. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities such as peptides and protein therapeutics as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division.
Principal Scientist (Director), Clinical Research, Immunology Merck & Co IncPrincipal Scientist (Director), Clinical Research, ImmunologyBoston, MA$255,800–$402,700 / yearWork closely with a cross-functional group of experts in commercialization, regulatory affairs, statistics, and manufacturing to manage clinical development projects; and assist the Senior Director, Associate Vice-President/Vice-President and Product Development Team Lead in ensuring that appropriate corporate personnel is informed of the progress of studies of our company and competitors' drugs and internal and external expert opinion on scientific questions relevant to his/her areas of responsibility. With a focus on late-stage development, the Clinical Director will manage the entire cycle of clinical development, including determination of appropriate disease indications to pursue and subsequent study design, initiation, execution, monitoring, analysis, regulatory filing, and publication.
Principal ATA Engineer CarGurus IncPrincipal ATA EngineerBoston, MA$170,000–$212,000 / yearPosition Pay Range 170000 - 212000 USD Working at CarGurus We reward our Gurus curiosity and passion with best-in-class benefits and compensation including equity for all employees both when they start and as they continue to grow with us. Thoughtful perks like daily free lunch a new car discount meditation and fitness apps commuting cost coverage and more help our people create space for what matters most in their personal and professional lives.
Senior Principal Scientist, Quantitative Biosciences Merck & Co IncSenior Principal Scientist, Quantitative BiosciencesBoston, MA$214,100–$337,000 / yearD. or equivalent in biology, pharmacology, analytical chemistry, biochemistry, pharmaceutical sciences, or a related STEM discipline AND 12+ years of relevant experience in a pharmaceutical, biotechnology, or closely related research setting; MS and 15+ years of experience; OR BS and 16+ years of experience. As a senior scientific leader in Quantitative Biosciences, you will lead the Boston mass spectrometry capability supporting in vitro and in vivo pharmacology, advise multidisciplinary project teams, and influence broader QB strategy.
Principal Process Engineer, Manufacturing Process Development Terrestrial Bio IncPrincipal Process Engineer, Manufacturing Process DevelopmentWoburn, MA$140,000–$170,000 / yearYou will leverage your creativity, analytical mindset, soft skills, and prior process development experience to: Contextualize process tradeoffs within a risk-based product development framework; define and execute a robust development strategy for early and late phase programs; document process development history internally and in regulatory filings. Making microarray patches with hundreds or thousands of drug-loaded polymer microneedles, and ensuring consistent quality across a patch, a batch, or a manufacturing campaign, requires many processes to go just right, many, many times.
Principal Engineer Liberty Mutual Holding Company IncPrincipal EngineerBoston, MAThe Portfolio Principal Engineer (PPE) role within the DAE BDSE Digital, Customer and Service data delivery portfolio is the technical leader who collaborates with various domain stakeholders, engineering teams, and leadership to ensure that the teams have the necessary support and expertise to deliver maximum business value to our customers. We encourage you to apply and bring your expertise if you''re a: Technical problem solver: Going far beyond simply developing error-free source code, test scripts, components and system architectures, you''ll document and build deployment guides aimed at maintaining robust, relevant applications, integrations and data patterns.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Principal Program Scheduler Torch TechnologiesPrincipal Program SchedulerHanscom AFB, MassachusettsBy enabling aircrews to electronically receive and process tasking orders, intelligence inputs, target coordinates, and mission‑critical flight and weapons data, MPS enhances combat effectiveness, increases sortie generation rates, and improves aircrew readiness and survivability across the Combat Air Forces (CAF) and Mobility Air Forces (MAF). Several factors can influence the salary for a position including but not limited to, Federal Government contract labor categories and contract wage rates, geographic location, business considerations, scope and responsibilities of the position, local or other applicable market conditions, and internal equity.
Principal Finance Manager Onto Innovation IncPrincipal Finance ManagerWilmington, MAOnto Innovation is a leader in process control, combining global scale with an expanded portfolio of leading-edge technologies that include: 3D metrology spanning the chip from nanometer-scale transistors to micron-level die-interconnects; macro defect inspection of wafers and packages; metal interconnect composition; factory analytics; and lithography for advanced semiconductor packaging. In this role, you will support multiple business and project teams with competing priorities while providing clear financial insight, disciplined budget management, and actionable analysis to leadership.
PRINCIPAL R&D/PRODUCT DVL ENGINEER(SA) TE Connectivity plcPRINCIPAL R&D/PRODUCT DVL ENGINEER(SA)Marlborough, MADrive thought leadership by educating and influencing internal and external stakeholders, from executives and product teams to key decision-makers in customer organizations, on emerging industry trends, TE's technical capabilities, and high-value engineering solutions. Serve as the primary technical liaison for TE's customers, actively engaging with hyperscalers, OEMs, and system architects to gain deep insights into next-generation compute, AI, storage, and networking challenges.
Principal Noise Consultant AcentechPrincipal Noise ConsultantCambridge, MAFull timeAcentech, a multidisciplinary design consulting firm specializing in acoustics, vibration, audiovisual systems, IT and security system design seeks to hire a senior- to principal-level consultant to work with our Noise and Vibration team. We foster a collaborative environment of diverse talent, and encourage people of color, lesbian, gay, bisexual, transgender, queer and non-binary people, neurodivergent, veterans, parents, and individuals with disabilities to apply.
Principal Scientist SanofiPrincipal ScientistWaltham, MA$122.25–$176.58 / hourThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Main responsibilities: Lead scale-up activities from bench scale to pilot scale (200L-2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Principal Commercial Data Engineer MGM Resorts InternationalPrincipal Commercial Data EngineerMA$126,200–$168,300 / yearYou will partner closely with senior leadership, architects, data science, analytics, IT, and business stakeholders to design resilient, scalable, and trusted data systems that support real-time decisioning, advanced analytics, and AI/ML applications. THE DAY-TO-DAY: Define the multi-year architectural vision for MGM's Lakehouse platform, including compute, storage, orchestration, semantic layers, governance, and reliability.