The lab employs a multi-disciplinary approach, combining whole-genome sequencing, spatial transcriptomics, single-nucleus epigenomics and RNA-seq, and multiplex protein imaging, to dissect the complex interplay between neurons and non-neuronal cells in the brain and spinal cord, to study diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative disorders. The lab employs a multi-disciplinary approach, combining genome engineering, pooled genetic screens, molecular genomics, synthetic biology, and imaging, to dissect the inner workings of the human genome and to develop next-generation therapies for diverse diseases, including cancer, rare inherited disorders, brain disorders, autoimmunity and others.