The research areas of interest include, but are not exclusive to: (1) Imaging and therapeutic applications focused on the brain, such as MRI-guided focused ultrasound, blood brain barrier opening, passive cavitation imaging, therapy for neurodegenerative diseases and brain cancer and neuromodulation: (2) oncologic imaging and therapy applications including multimodality imaging, early detection biomarkers, development of methods for early therapy response prediction, development of agents for image guided drug delivery, gene delivery and/or immunotherapy; (3) development of agents and methods for contrast enhanced ultrasound, magnetic particle imaging, and /or quantitative ultrasound; and (4) ultrasound and/or photoacoustic imaging hardware and software including development of transducer technology, real-time acquisition and reconstruction, ultrasound localization microscopy and super-resolution methods, and artificial intelligence driven imaging methods. The Department of Biomedical Engineering, which is jointly housed in the School of Medicine and in the Case School of Engineering, was one of the pioneering BME programs in the country (founded 1968), and is home to 29 tenure-track faculty, over 200 graduate students and approximately 500 undergraduate students.