The NIH-funded laboratory studies the effects of radiation on the heart, lungs, and tumors, with three goals: understanding and preventing radiation-induced cardiac and pulmonary injury in patients with cancer; developing localized cardiac radiation as a therapy for cardiac disease; and identifying strategies, including dietary and metabolic approaches, that enhance the efficacy of radiation therapy in tumors. Projects use rodent models of heart failure, pulmonary toxicity, and cancer; image-guided small animal irradiation; and cell, iPSC-derived cardiomyocyte, and organoid systems, combined with single-nucleus RNA sequencing, proteomics, and flow cytometry.