Key responsibilities include maintaining strict infection-control practices, screening for contagious illnesses, preparing isolation rooms and PPE, collecting accurate vital signs and medical histories, assisting with specimens, testing, and immunizations, and helping children remain calm during procedures. The Clinic Office Assistant (RN, LPN, CMA/RMA) also manage patient communications, scheduling, referrals, laboratory coordination, and electronic medical record documentation, making attention to detail, compassion, and adherence to safety protocols essential to the role.