Principal Scientist, Analytical Development Sana BiotechnologyPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.
Sr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (In Vivo Biology)San Francisco, CA$71,250–$187,000 / yearWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies - alongside supporting ex vivo and in vitro assays - to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).
Sr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology) Eli Lilly and CompanySr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology)San Francisco, California$71,250–$187,000 / yearWorking with a high degree of independence under the guidance of a senior scientific lead and/or director, the successful candidate will design, execute, and interpret in vivo (mouse and rat) studies — alongside supporting ex vivo and in vitro assays — to identify and validate novel druggable oncology targets, de-risk on-target toxicity liabilities, and advance targets from the pre-portfolio pipeline into the formal discovery portfolio. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Principal Scientist, Translational Genetics CytokineticsPrincipal Scientist, Translational GeneticsSouth San Francisco, California$202,500–$236,250 / yearCytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Analyze and integrate multi-omics data (genomics, transcriptomics, proteomics, metabolomics) to identify causal variants and pathways associated with cardiovascular diseases.
Principal Scientist, Bioinformatics Nkarta, Inc.Principal Scientist, BioinformaticsSouth San Francisco, CA$180,000–$215,000 / yearA central focus of this role is to drive and execute on Nkarta's strategy for single-cell and spatial transcriptomics, leveraging scRNA-seq, spatial, and functional genomics approaches to drive translational insights, biomarker development, and clinical decision-making in early development. Nkarta is a publicly traded (Nasdaq symbol NKTX), clinical-stage biotechnology company headquartered in South San Francisco, focused on advancing the development of allogeneic, off-the-shelf natural killer (NK) cell therapies to treat autoimmune disease.
Principal Scientist, CMC Analytical Development - Commercial Products Denali TherapeuticsPrincipal Scientist, CMC Analytical Development - Commercial ProductsSouth San Francisco, CA$159,000–$207,000 / yearAs the product transitions into routine commercial production and Denali pursues marketing applications in additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical Development Team to serve as a Commercial Analytical Lifecycle Lead. The Commercial Analytical Lifecycle Lead is expected to partner closely with peer Late Stage Analytical Development and Bioassay Development Leads responsible for driving successful analytical transfer & registration of a second-source manufacturing and QC site.
Principal Scientist, CMC Analytical Development - Commercial Products Denali Therapeutics IncPrincipal Scientist, CMC Analytical Development - Commercial ProductsSouth San Francisco, CA$159,000–$207,000 / yearAs the product transitions into routine commercial production and Denali pursues marketing applications in additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical Development Team to serve as a Commercial Analytical Lifecycle Lead. The Commercial Analytical Lifecycle Lead is expected to partner closely with peer Late Stage Analytical Development and Bioassay Development Leads responsible for driving successful analytical transfer & registration of a second-source manufacturing and QC site.
Principal Scientist, SOP & Workflow Automation Champion, AI for Drug Discovery (AIDD) Genentech IncPrincipal Scientist, SOP & Workflow Automation Champion, AI for Drug Discovery (AIDD)South San Francisco, CA$201,300–$373,800 / yearThe new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide. We have developed novel machine learning capabilities for large molecule discovery, but translating those capabilities into scalable, operationalized workflows at the organizational level requires both scientific credibility and strategic engineering acumen.
Principal Scientist, Inflammation Amgen Inc.Principal Scientist, InflammationSouth San Francisco, CAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Familiarity with small and large molecule drug discovery, mechanism of action studies, ELISA, MSD, and flow cytometry-based immune cell profiling, single-cell RNA sequencing (scRNA-Seq), CRISPR/Cas9, and omics data analysis experience a plus.
Principal Scientist, Analytical Development Sana Biotechnology IncPrincipal Scientist, Analytical DevelopmentSouth San Francisco, CA$200,000–$240,000 / yearPhysical Demands: Employees in this position may be required to perform the following physical activities: standing, walking, and sitting for extended periods of time; frequent use of the hands, fingers, wrist, and greater arm to handle small materials, tools, boxes, and trays; lifting and carrying objects up to 10 Ibs; occasional overhead reaches and lifts; occasional lifts and reaches below the knee; occasional pushing and pulling of materials and objects with moderate forces; occasional crouching/kneeling, twisting, and squatting movements. Act as a key contributor in developing and qualifying pivotal stage potency, immunoassay, and other cell-based methods to support the characterization, process development, release testing, and stability testing of cell therapy products.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution MedicinesPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CaliforniaAs a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS.
Principal Scientist Genentech IncPrincipal ScientistSouth San Francisco, CA$143,200–$265,900 / yearJoining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools-including Generative AI-to drive biological insights. Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
Principal Scientist - Oligonucleotide Design and Chemistry Genentech IncPrincipal Scientist - Oligonucleotide Design and ChemistrySouth San Francisco, CA$143,200–$266,000 / yearScientific Leadership: Proven track record of leading scientific initiatives, mentoring team members, and driving cross-functional collaborations (evidenced by publications or patents). The Therapeutic Modalities and Technologies group in the Protein Sciences organization at Genentech is responsible for the design and generation of new therapeutic modalities that combine the engineering and analytical principles of multiple scientific disciplines.
Principal Scientist, Analytical Chemistry Revolution Medicines IncPrincipal Scientist, Analytical ChemistryRedwood City, CA$190,000–$238,000 / yearThe company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Design and implementation of discovery analytics, analytical data integration through collaboration with LabOS team, Data Sciences and Data Analytics functions to develop and implement automated high-throughput analytical methods that enhance efficiency and data quality.
Principal Scientist, Lab Head, Immunology, Cell Therapy Genentech IncPrincipal Scientist, Lab Head, Immunology, Cell TherapySouth San Francisco, CA$143,200–$265,900 / yearThe successful candidate will lead a highly productive research team, integrating efforts across cross-functional teams to identify new targets and therapeutic hypotheses, and to advance transformative therapeutics from preclinical studies into early clinical development. Key responsibilities include leading and managing a highly-productive research team, generating high-quality, original research that advances our understanding of autoimmune disease and contributing directly to the initiation and advancement of novel pipeline projects.
Principal Scientist, Cancer Pharmacology, Translational Research Revolution Medicines IncPrincipal Scientist, Cancer Pharmacology, Translational ResearchRedwood City, CA$190,000–$238,000 / yearThe Opportunity: As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic leadership for RAS(ON) inhibitor programs by translating mechanistic insights in RAS biology into impactful pharmacology strategies and translational study plans. The company's RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.
Principal Scientist, Antibody Engineering & Rational Design California Life CompanyPrincipal Scientist, Antibody Engineering & Rational DesignSouth San Francisco, CA$198,000–$241,000 / yearCalico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Demonstrated ability to work intimately with data scientists and ML engineers and able to articulate biological constraints (e.g., immunogenicity, manufacturability) to computational teams and interpret their in silico outputs for experimental validation.
Principal Scientist, Bioanalytic Epicrispr Biotechnologies IncPrincipal Scientist, BioanalyticSouth San Francisco, CA$165,000–$184,000 / yearOpportunity: Epicrispr Biotechnologies is seeking a highly motivated and experienced Principal Scientist, Bioanalytical to lead the development and execution of bioanalytical strategies supporting our pipeline. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.
Senior/Principal AI/ML Computational Scientist Genentech IncSenior/Principal AI/ML Computational ScientistSouth San Francisco, CA$156,200–$290,200 / yearWho You Are: PhD in biomedical engineering, bioengineering, computer science, computational biology, bioinformatics, data science, statistics, computer vision, image analysis, or a related quantitative discipline; Senior Scientist level (0-2 years) Principal Scientist (3+ years of experience). Our work focuses on extracting quantitative, reproducible, and biologically meaningful information from digital histopathology images and related imaging datasets to support preclinical safety assessment, mechanistic investigation, and translational research.
NewAssociate Principal Scientist, Clinical Research Merck & Co IncAssociate Principal Scientist, Clinical ResearchSouth San Francisco, CA$142,400–$224,100 / yearTranslational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Leads and directs teams through key study planning, development, and execution activities, including program overviews, issue escalation and mitigation, senior management presentations, cross-functional governance meetings, and advisory meeting preparation.