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Vertex Pharmaceuticals logo

Principal Full Stack AI Engineer Vertex Pharmaceuticals

Principal Full Stack AI Engineer
Boston, Massachusetts
  • $166,640–$250,000 / year

In this role you will develop AI agents and the services, APIs, and interfaces around them, andconnect the platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows. Enable AI workflows to interact reliably with core enterprise platforms such as collaboration tools, knowledge systems, workflow tools, and line-of-business applications.

22 days ago
Vertex Pharmaceuticals, Inc logo

Senior Principal AI Engineer Vertex Pharmaceuticals, Inc

Senior Principal AI Engineer
Boston, MA
  • $188,000–$282,000 / year

In addition to building out the core platform, this engineer will own the vision and day-to-day operations of a centralized AI Gateway / Control Plane / Control Tower that enables agent monitoring, observability, policy enforcement, governance, and operational controls across AI solutions at Vertex. Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.

27 days ago

Principal Product Manager - Low Voltage VEIR

Principal Product Manager - Low Voltage
Woburn, Massachusetts

Complete the full Preliminary Design phase product deliverable set for the SL Series in collaboration with SL Series subsystem product managers and product marketing manager, including application and use case presentations, product brochure, product presentations, guide specifications, product datasheets, and serviceability plan. The Principal PM is the primary product authority for VEIR’s low voltage system platform — translating data center customer requirements into precise product direction, orchestrating subsystem product managers to ensure cohesive system-level execution, and serving as the product team's primary interface for commercial engagements.

30+ days ago

Principal Electrical & Compliance Engineer VEIR

Principal Electrical & Compliance Engineer
Woburn, Massachusetts

VEIR’s initial focus is AI data centers behind the meter, with solutions engineered for repeatable deployment through reference designs and integrated controls, designed to incorporate learnings as deployments scale. Own the electrical integration interface designs between VEIR system and datacenter distribution systems, from medium-voltage (MV) switchgear and transformers through low-voltage (LV) switchgear, busway, PDUs, power sidecars, and rack busbars.

30+ days ago

Oliver Wyman - Associate/ Engagement Manager / Principal - Tech Innovation Practice (Technical Architecture & Delivery Focus) Marsh & McLennan Companies, Inc.

Oliver Wyman - Associate/ Engagement Manager / Principal - Tech Innovation Practice (Technical Architecture & Delivery Focus)
Boston, MA
  • $190,000–$195,000 / year

We aim to attract and retain the best people and embrace diversity of age background, disability, ethnic origin, family duties, gender orientation or expression, marital status, nationality, parental status, personal or social status, political affiliation, race, religion and beliefs, sex/gender, sexual orientation or expression, skin color, veteran status (including protected veterans), or any other characteristic protected by applicable law. With offices in more than 70 cities across 30 countries, Oliver Wyman combines deep industry knowledge with specialized expertise in strategy, operations, risk management, and organization transformation.

30+ days ago
New

Associate Principal- Corporate Strategy Trinity Life Sciences

Associate Principal- Corporate Strategy
Waltham, Massachusetts

Trinity’s salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. For more than 30 years, the world’s leading pharmaceutical, biotech, and medtech companies have relied on Trinity’s foresight, execution, and partnership to deliver confident product launches, decisive market advantage, and measurable patient impact.

3 days ago

Associate Principal- Commercial Strategy Trinity Life Sciences

Associate Principal- Commercial Strategy
Waltham, MA
  • $156,000–$234,000 / year

Trinity's salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. For more than 30 years, the world's leading pharmaceutical, biotech, and medtech companies have relied on Trinity's foresight, execution, and partnership to deliver confident product launches, decisive market advantage, and measurable patient impact.

30+ days ago

Associate Principal, Commercial Strategy Trinity Life Sciences

Associate Principal, Commercial Strategy
Waltham, MA
  • $156,000–$234,000 / year

Trinity's salary bands account for a wide range of factors that are considered in making compensation decisions including but not limited to skill sets and market demand for skills; level of experience and training; specific qualifications, performance, time in role/company, geographic location, and other business and organizational needs. For more than 30 years, the world's leading pharmaceutical, biotech, and medtech companies have relied on Trinity's foresight, execution, and partnership to deliver confident product launches, decisive market advantage, and measurable patient impact.

30+ days ago

Principal DevOps Engineer Evolv Technologies Inc.

Principal DevOps Engineer
Waltham, MA
  • $137,000–$220,000

In accordance with state and local pay transparency laws—including those in California, Colorado, Massachusetts, New York, New Jersey, and others—we disclose salary ranges in all job postings and provide additional information upon request. In this role, you will partner closely with Platform, Security, Compliance, and Engineering teams to enable reliable, audit-ready cloud environments while balancing velocity, security, and operational excellence.

30+ days ago
New

Principal Data Links and Communications Engineer - Active Top-Secret Clearance Macpower Digital Assets Edge Private Limited

Principal Data Links and Communications Engineer - Active Top-Secret Clearance
Bedford, MA
  • $135,000–$150,000 / year

This includes interface with Air Combat Command, Air Force Command and Control Integration Center, Joint Interoperability Test Command, Space and Naval Warfare Systems Command, and all levels of the organizations that develop and manage the C3 and encryption key distribution infrastructure for controlling a networked system, providing technical advice on C4 issues, including pre-launch conditioning and planning, aircraft-weapon pre- and post-release communications, and real-time targeting. This includes interfacing with the Federal Department of Defense (DoD), United States Air Force (USAF), United States Army, and Joint communities to ensure the data link communications capability complies with the applicable Federal Aviation Administration, Defense Information Systems Agency (DISA), National Security Agency (NSA), Service Acquisition Executive, Joint Mission Planning System (JMPS), Damage Assessment and Casualty Report business and technical rules.

3 days ago
New

Principal Acquisition Analyst Strategy & Documentation | Active Secret Security Clearance (or higher) Macpower Digital Assets Edge Private Limited

Principal Acquisition Analyst Strategy & Documentation | Active Secret Security Clearance (or higher)
Bedford, MA
  • $140,000–$165,000 / year

Interpret complex tasks from higher-level organizations (e.g., PEO Staff , Air Staff , DoD Staff , Congressional Staff ), and organize multi-functional team responses. The candidate must have hands-on experience in acquisition reporting (e.g., DAES, MAR, SAR, GAO audits), and knowledge of program and/or financial management is a strong plus.

3 days ago
New

Principal Network Architect - Active Top Secret Security Clearance Macpower Digital Assets Edge Private Limited

Principal Network Architect - Active Top Secret Security Clearance
Bedford, MA
  • $150,000–$185,000 / year

Executive Summary: Our client is seeking a Principal Cyber and Network Architect with an active Top Secret Security Clearance for a key role at Hanscom Air Force Base (AFB) in Bedford, MA . Collaborate with the Identity, Credentials, and Access Management (ICAM) team to ensure cross-division and cloud usability (connected and disconnected environments).

3 days ago
New

Principal System Interoperability Engineer - Active Secret Security Clearance Macpower Digital Assets Edge Private Limited

Principal System Interoperability Engineer - Active Secret Security Clearance
Bedford, MA
  • $130,000–$155,000 / year

Executive Summary: Our client is seeking a Principal System Interoperability Engineer with an active Secret Security Clearance for a role based at Hanscom Air Force Base (AFB) in Bedford, MA . The ideal candidate will have over 15 years of experience in data links and communications engineering, including 5+ years supporting the Department of Defense (DoD) .

3 days ago

Principal Associate I, Plant Quality Assurance - 2ND SHIFT Replimune

Principal Associate I, Plant Quality Assurance - 2ND SHIFT
Framingham, Massachusetts
  • $120,000–$155,000 / year

The Principal Associate I/II, Plant Quality Assurance (PQA) reports to the Associate Director, Quality Assurance and is responsible for on-going Quality oversight to ensure real time quality oversight for Drug Substance, Drug Product, and all other production and QC testing activities according to current good manufacturing practices (cGMP), good documentation practices (GDP) and other applicable regulations. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.

18 days ago
UnitedHealth Group Inc. logo

Principal Systems Management Analyst - Epic Healthy Planet UnitedHealth Group Inc.

Principal Systems Management Analyst - Epic Healthy Planet
Auburndale, MA
  • $112,700–$193,200 / year

As a Principal Systems Management Analyst focusing on Epic Healthy Planet and Epic Cheers, you will partner with clinical, operational, and technical leadership to drive population health strategies and patient engagement workflows. Evaluate current-state workflows and identify opportunities to optimize Healthy Planet functionality to improve care gap closure, patient outreach, quality performance, and provider efficiency.

13 days ago

Principal Mechanical Engineer Berkshire Grey Inc.

Principal Mechanical Engineer
Bedford, MA

The candidate must be highly experienced and autonomous with respect to designing, fabricating, and testing new designs, as well as launching new products into production and supporting systems fielded at customer sites. Significant experience designing systems that are used in industrial settings, expecting to balance cost and durability for maximum customer success over the capital equipment's full depreciation lifespan.

15 days ago

Principal Modeling And Simulation Engineer Berkshire Grey Inc.

Principal Modeling And Simulation Engineer
Bedford, MA

In the role of Principal Modeling and Simulation Engineer, you will lead the development of high-fidelity simulation platforms and digital twins that drive system design, validation, and deployment. This role blends advanced software engineering with modeling and simulation, enabling rapid development, testing, and optimization of complex robotic systems.

15 days ago
UnitedHealth Group Inc. logo
New

Principal AI Program Manager, Appeals Innovation And Automation - Remote UnitedHealth Group Inc.

Principal AI Program Manager, Appeals Innovation And Automation - Remote
Boston, MA
Remote
  • $91,700–$163,700 / year

This role serves as the bridge between business operations, clinical leadership, technology teams, legal, compliance, privacy, security, and enterprise governance to ensure the responsible deployment of AI capabilities that improve quality, efficiency, consistency, and user experience. The ideal candidate will possess deep expertise in AI agents, workflow automation, generative AI, and healthcare operations, with a proven ability to translate business challenges into AI-enabled solutions.

5 days ago
New

Principal Software Engineer, Semantic Data Services WEX Inc.

Principal Software Engineer, Semantic Data Services
Boston, MA
  • $200,600–$250,400 / year

10+ years of experience in software engineering, data engineering, distributed systems, data platforms, or related technology areas, with demonstrated experience operating at Staff, Principal, or equivalent technical scope. Experience with technologies such as Spark, Flink, Kafka, Iceberg, Snowflake, Databricks, cloud-native data services, graph databases, or equivalent large-scale data technologies.

6 days ago

Principal Electrical Engineer RE Build Manufacturing, LLC

Principal Electrical Engineer
Wilmington, MA
  • $165,000–$250,000 / year

An experienced engineering leader with a broad range of electrical engineering disciplines, including analog and digital circuit design, power electronics, PCB design, sensors, instrumentation, embedded electronics, and electromechanical systems. We operate an advanced, end-to-end manufacturing platform that partners with industrial companies and innovators to take products from first concept to full-scale production in critical verticals including aerospace and defense, electrification, medical, energy and environment, and robotics and automation.

21 days ago
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