Scientist II / Senior ML Scientist, Data-Efficient Learning for Drug Discovery Lila Sciences IncScientist II / Senior ML Scientist, Data-Efficient Learning for Drug DiscoveryCambridge, MA$228,000–$358,000 / yearThis role connects model training with scientific decision-making: data acquisition plans should be useful to computational chemists evaluating compound priorities, computational biophysicists deciding when simulation is warranted, and cofolding modelers deciding which protein-ligand data would improve structure-aware models. You will use and develop approaches across active learning, meta-learning, fine-tuning, uncertainty estimation, experimental design, and multimodal modeling to help Lila build closed-loop systems that learn efficiently from targeted data acquisition.
Scientist II/Senior Characterization Scientist, Condensed Matter Lila Sciences IncScientist II/Senior Characterization Scientist, Condensed MatterCambridge, MA$128,000–$198,000 / yearWorking at the intersection of experimental science, robotics, and AI, you will collaborate with experimentalists, systems engineers, and machine learning scientists to build scalable characterization workflows that accelerate the path to scientific superintelligence in superconductivity and magnetism. LILA combines advanced AI models with proprietary AI Science Factory instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy.
Scientist II / Senior ML Scientist, Cofolding and Structure-Aware ML Lila Sciences IncScientist II / Senior ML Scientist, Cofolding and Structure-Aware MLCambridge, MA$228,000–$358,000 / yearYou will work with ML researchers, computational chemists, computational biophysicists, data engineers, and drug discovery teams to develop models that learn from DEL and related datasets, connect molecular and protein context, and improve AI-driven discovery decisions. Use contrastive learning, representation learning, self-supervised learning, or related methods where they help improve cofolding models trained on molecules, proteins, structures, and experimental readouts.
Associate Scientist/Scientist I, Protein Science Developability Lila Sciences IncAssociate Scientist/Scientist I, Protein Science DevelopabilityCambridge, MA$88,000–$144,000 / yearIn this role, you will design, optimize, and execute protein purification workflows using chromatography systems, develop and validate bioassays, and apply mass spectrometry techniques to support protein characterization across Lila''s autonomous laboratory platform. Hands-on experience in LC-MS techniques for protein characterization, including intact mass analysis, peptide mapping, PTM identification, and glycosylation profiling, with exposure to interpretation of complex mass spectral data and troubleshooting instrument performance.
Scientist II/Sr. Scientist I, In-Vivo Pharmacology (Must Have Immunology Experience) Antares TherapeuticsScientist II/Sr. Scientist I, In-Vivo Pharmacology (Must Have Immunology Experience)Boston, Massachusetts$145,000–$185,000 / yearThe successful candidate will contribute across multiple discovery-stage programs through IND-enabling studies, working closely with cross-functional partners in biology, medicinal chemistry, and DMPK. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job.
Scientist II Or Senior Scientist, Protein Analytics Alloy TherapeuticsScientist II Or Senior Scientist, Protein AnalyticsWaltham, MA$130,000–$160,000 / yearAlloy's Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities. Deliver: Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and developability packages that inform key program decisions.
Scientist II or Senior Scientist, Protein Analytics Alloy TherapeuticsScientist II or Senior Scientist, Protein AnalyticsWaltham, MA$130,000–$160,000 / yearAbout the Role Alloy’s Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities. Deliver : Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and developability packages that inform key program decisions.
Scientist I / Scientist II, Computational Protein Generation Generate Biomedicines IncScientist I / Scientist II, Computational Protein GenerationSomerville, MA$140,000–$200,000 / yearThe ideal candidate combines deep structural intuition with a demonstrated ability to rapidly assess and apply protein design methods and metrics across diverse design problems, thinks in terms of reusable capabilities, benchmarks, and feedback loops across applications, and uses modern generative models and experimental readouts to guide iterative design cycles across modalities. This role sits at the intersection of machine learning, structural biology, and therapeutic development, where you will stay at the leading edge of internal and external models for de novo protein design and systematically benchmark, integrate, and apply them within tightly integrated design-build-test-learn cycles to advance our therapeutic pipeline and impact patients' lives.
Associate Scientist / Bench Scientist Integrated Resources, IncAssociate Scientist / Bench ScientistBoston, MassachusettsContractorWe are seeking motivated and creative individuals to join our Cell Line Technology team to contribute to ongoing efforts in engineering and identifying superior host cell lines for the manufacturing of therapeutic proteins. Candidates with experience performing transfections, basic molecular biology techniques (gene cloning, plasmid construction PCR, etc) cell line screening and characterization will be highly valued.
Scientist/Senior Scientist, Assay Development - Neuroscience Biomarkers Spear BioScientist/Senior Scientist, Assay Development - Neuroscience BiomarkersWoburn, MassachusettsProvide scientific leadership and translate biomarker biology into assay-design strategies by optimizing for clinically relevant molecular forms, isoforms, post-translational modifications, cleavage fragments, aggregation states, epitopes, and sample types. The successful candidate will help optimize assay strategies, identify the most relevant molecular forms and epitopes, evaluate preanalytical variables and matrix effects, interpret clinical-sample data, and troubleshoot complex assay-development challenges.
Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics Spear BioScientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and BiophysicsWoburn, MassachusettsTroubleshoot assay-performance issues, including low signal, nonspecific background, limited sensitivity, poor reproducibility, matrix effects, instability, and lot-to-lot variability, using a mechanistic understanding of binding kinetics, affinity, avidity, thermodynamics, steric effects, and molecular interactions. The Scientist / Senior Scientist will design, optimize, and troubleshoot innovative protein-detection assays that integrate antibody-based recognition, nucleic-acid interactions, conjugation chemistry, reaction kinetics, and quantitative analytical methods.
Scientist/Senior Scientist for Pharmacology BiocytogenScientist/Senior Scientist for PharmacologyWaltham, MassachusettsBiocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology. The successful candidate will be a critical member of our fast-paced and expanding CRO team, actively engaging in both hands-on experimental work and strategic project management to support biotech and pharmaceutical partners.
Scientist/Senior Scientist For Pharmacology BiocytogenScientist/Senior Scientist For PharmacologyWaltham, MABiocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology. The successful candidate will be a critical member of our fast-paced and expanding CRO team, actively engaging in both hands-on experimental work and strategic project management to support biotech and pharmaceutical partners.
Senior Scientist or Principal Scientist, Targeted Proteomics Kymera Therapeutics IncSenior Scientist or Principal Scientist, Targeted ProteomicsWatertown, MA$115,000–$215,000 / yearDomain leadership with cross-functional drug discovery: Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and enabling program advancement through high-impact experimental data. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.
Data Scientist / Senior Data Scientist Berkshire Hathaway Specialty Insurance CoData Scientist / Senior Data ScientistBoston, MAIn addition, you will conduct in-depth evaluation of vendor models, research and develop internal views of exposure and risks, consult on account-specific risk analyses, and develop internal tools to facilitate account underwriting decision-making and other related activities. Experience applying advanced statistical techniques and machine learning to large data sets, especially in areas of structural performance, natural catastrophe hazard, building exposure data, geospatial data, or insurance claims data.
Scientist/Sr. Scientist-Preclinical Antibody Drug Development BiocytogenScientist/Sr. Scientist-Preclinical Antibody Drug DevelopmentWaltham, MAThis role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize advanced antibody engineering techniques to improve binding affinity, specificity, stability, and therapeutic functionality.
Scientist / Senior Scientist, Bioanalytical LC–MS – Oligonucleotide Alloy TherapeuticsScientist / Senior Scientist, Bioanalytical LC–MS – OligonucleotideWaltham, Massachusetts$126,000–$150,000 / yearThis LC–MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity. Exposure & Disposition: Apply LC–MS and other methods to assess oligonucleotide–protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure.
Scientist / Senior Scientist, Bioanalytical Lc-Ms - Oligonucleotide Alloy TherapeuticsScientist / Senior Scientist, Bioanalytical Lc-Ms - OligonucleotideWaltham, MA$126,000–$150,000 / yearThis LC-MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity. Exposure & Disposition: Apply LC-MS and other methods to assess oligonucleotide-protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure.
Research Scientist, Lentiviral Vector Purification and Analytics Novartis AGResearch Scientist, Lentiviral Vector Purification and AnalyticsCambridge, MA$81,200–$150,800 / yearKey responsibilities:This is a lab-based position that requires hands-on execution of activities related to lentiviral vector purification including clarification, chromatography and TFF.Execute analytical methods (molecular- and cell-based) to assess quality of the purified vector. The Lentiviral Vector (LVV) Team in the Biologics Research Center (BRC) at Novartis, Cambridge, MA is seeking a highly motivated Research Scientist with experience in production and purification of viral vectors to join our team.
Scientist/Sr. Scientist, mRNA Display Zealand PharmaScientist/Sr. Scientist, mRNA DisplayCambridge, Massachusetts$125,000–$170,000 / yearExperience building custom cell-free display systems from scratch strongly preferred; experience with other in vitro display technologies (e.g., ribosome display) and cell-free protein/peptide expression systems (e.g., IVTT, CFS) is a plus. Your new position As a Scientist or Senior Scientist in mRNA Display, you will play a central scientific role in our new Molecular Platform Development organization, driving peptide and mini-protein discovery through mRNA display technology.