Senior Clinical Pharmacologist Regeneron PharmaceuticalsSenior Clinical PharmacologistCambridge, MA$128,600–$210,000 / yearAs a Senior Clinical Pharmacologist this individual is expected to plan, design, implement and analyze in-vivo and in-vitro pharmacokinetic & pharmacodynamic studies working with Clinical Pharmacology, Quantitative Pharmacology, Pharmacometrics/Pharmacodynamics (PK/PD), Toxicology, Bioanalytical, Therapeutic Focus areas and Clinical Development / Regulatory Affairs teams. Performs analyses such as compartmental modeling, PopPK, translational modelling, disease modelling, Pop PK/PD, E-R analyses (or work closely with Research Specialist or Pharmacometrics Stats Programming team) to deliver Pharmacometrics results, interpretation and discussion.
NewAssociate Director Clinical PharmacologySenior Clinical Pharmacologist Oncology AbbVie IncAssociate Director Clinical PharmacologySenior Clinical Pharmacologist OncologyWaltham, MASenior Clinical Pharmacologist: PhD with 0 years of experience, or Pharm D with 2+ years of experience in a relevant field, Master's Degree or equivalent education and typically 8+ years of experience, Bachelor's Degree or equivalent education and typically 10+ years of experience; (*relevant field includes experience with PK, PBPK, PK-PD, Pharmacometrics or systems pharmacology, Drug metabolism/Transporters). PhD with typically 4+ years of experience or Pharm D with typically 6+ years of experience in a relevant field, Master's Degree or equivalent education and typically 12+ years of experience, Bachelor's Degree or equivalent education and typically 14+ years of experience;(*relevant field includes experience with PK, PBPK, PK-PD, Pharmacometrics or systems pharmacology, Drug metabolism/Transporters).
Director, Head of Program Management Tessera Therapeutics IncDirector, Head of Program ManagementSomerville, MA$186,000–$239,000 / yearCompany Summary: Tessera Therapeutics is pioneering Gene Writing- a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Guiding and empowering Program Managers to drive the development and management of integrated program plans (including timelines, assumptions, scenarios, risks, critical path, decision maps, goals, and budget drivers).
SVP, Clinical Development Amylyx Pharmaceuticals IncSVP, Clinical DevelopmentCambridge, MARemote$416,000–$468,000 / yearThe Senior Vice President (SVP) of Clinical Development will provide strategic direction and technical leadership to the clinical development team, including clinical-regulatory development planning, clinical trial design, implementation and execution, clinical data analysis and management, and clinical competitive intelligence. Overall, the main responsibility will be to provide strategic leadership for the clinical and medical aspects for the various programs and work closely with a cross-functional team to align the clinical development plan with the overall development strategy of the relevant products.
Research Leader / Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA Isomorphic LabsResearch Leader / Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MACambridge, MAThese are exciting opportunities to work closely with world-leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. These roles are ideal for experienced in vitro pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays, and extensive experience of providing quantitative in vitro pharmacology expertise within drug discovery projects.
Research Leader / Senior Scientist (In Vitro / Cellular Pharmacology), Cambridge, MA Isomorphic LabsResearch Leader / Senior Scientist (In Vitro / Cellular Pharmacology), Cambridge, MACambridge, MAClassification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. These roles are ideal for experienced in vitro pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays, and extensive experience of providing quantitative in vitro pharmacology expertise within drug discovery projects.
Associate Director, Quantitative Systems Pharmacology GSK plcAssociate Director, Quantitative Systems PharmacologyWaltham, MA$151,500–$252,500 / yearAs an Associate Director of Quantitative Systems Pharmacology (QSP) Expert, you will develop and apply QSP models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas. This role requires a highly motivated individual to develop and apply QSP models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas.
Senior Scientist In vitro / Cellular Pharmacology, Cambridge, MA Isomorphic Labs LimitedSenior Scientist In vitro / Cellular Pharmacology, Cambridge, MACambridge, MAThis is an exciting opportunity to work closely with world-leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. Act as a vital bridge between computational prediction and experimental reality, collaborating closely with: AI/ML and Data Science teams: To translate in silico predictions into testable hypotheses and provide clean data loops to train future models.
Senior Director, Clinical Pharmacology Vertex PharmaceuticalsSenior Director, Clinical PharmacologyBoston, Massachusetts$232,000–$348,000 / yearThe role’s responsibilities will include maintaining organizational processes across the group, influencing clinical program strategy, and integrating activities with other departments across the Global Research and Development organization, to help shape innovative and integrated clinical development plans. Manages a group of Clinical Pharmacologists at Director-level and below to set strategy, develop and execute Clinical Pharmacology plans and studies for Disease Area programs.
Associate Director Quantitative Systems Pharmacology Alnylam Pharmaceuticals IncAssociate Director Quantitative Systems PharmacologyCambridge, MA$175,800–$237,800 / yearWith minimal supervision, strategize, formulate and execute QSP modeling and simulation approaches for insights into dose selection, trial design, mechanistic understanding of the interaction between disease, biomarker and treatment response, predicting clinical outcomes etc. In this role, the candidate is expected to show a high degree of scientific curiosity and critical thinking ability with good oral and written communication skills, ability to work independently with minimal supervision in a highly matrixed environment.
Associate Director, Quantitative System Pharmacology Viridian Therapeutics IncAssociate Director, Quantitative System PharmacologyWaltham, MARemoteQualifications: Requires a PhD degree or equivalent with a minimum of 6+ years of combined academic and biotechnology or pharmaceutical experience in QSP/T, (m)PBPK, mathematics, chemical/biomedical engineer, physics, and/or Translational Sciences, including experience with therapeutic antibodies. Experience with QSP or (m)PBPK modeling in autoimmune or inflammation for biologicals (ie, monoclonal antibodies, or other modalities), and bring forward combination drug approaches leveraging QSP models to advance clinical trials.
Director, Clinical Pharmacology Alkermes PlcDirector, Clinical PharmacologyWaltham, MAIn 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts' Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.
Research Leader / Senior Scientist (In Vivo Pharmacology & Translational Sciences), Cambridge, MA Isomorphic LabsResearch Leader / Senior Scientist (In Vivo Pharmacology & Translational Sciences), Cambridge, MACambridge, MAAct as a vital bridge between computational prediction and experimental reality, collaborating closely with: ML and Data Science Teams: To translate in silico predictions into physical validation protocols and provide clean data loops to train future models, iteratively improving the predictive accuracy of our proprietary drug design platform. Classification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
NewSenior Director, In Vitro Biology & Molecular Pharmacology Schrodinger IncSenior Director, In Vitro Biology & Molecular PharmacologyFramingham, MA$230,000–$300,000 / yearSpearhead the organization wide hit finding strategy, collaborating across functions to design and execute screening campaigns across DEL, fragment-based, HTS/MTS, and chemoproteomic platforms, focusing on novel methods for undrugged targets. As a senior member of our Therapeutics Group, you'll direct strategy and execution across a pipeline of small molecule drug discovery programs, with a particular focus on undrugged targets, novel modalities, and novel hit finding approaches.
Director, Clinical Pharmacology AlkermesDirector, Clinical PharmacologyWaltham, MA$228,000–$246,000 / yearIn 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts' Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.
Senior Director, Clinical Pharmacology Amylyx Pharmaceuticals IncSenior Director, Clinical PharmacologyCambridge, MARemote$268,000–$302,000 / yearThe Senior Director, Clinical Pharmacology is a highly experienced clinical pharmacologist who will provide strategic scientific leadership across multiple development programs from Phase 1 through Phase 3. Reporting to the Vice President, Clinical Pharmacology, this individual will partner with cross-functional program teams to develop and execute clinical pharmacology strategies that support regulatory submissions and successful drug development. The successful candidate will work collaboratively with Clinical Development, Biometrics, Regulatory Affairs, Translational Medicine, Nonclinical, Medical Writing, and external partners to ensure robust clinical pharmacology strategies throughout development.
Associate Director, Pharmacology Formation BioAssociate Director, PharmacologyBoston, MA$177,500–$232,000 / yearManage CRO-executed pharmacology studies and related workflows, including protocol review, vendor oversight, data quality, timelines, budgets, study conduct, interpretation, final reports, organizational tracking systems, and use of technology, modeling, data analytics, literature mining, and AI-enabled tools to improve speed, rigor, reproducibility, and decision-making. This role is well suited for a scientifically rigorous, intellectually independent pharmacologist who can move fluidly across mechanisms, modalities, disease areas, and stages of development, with particular value placed on familiarity with immunology, animal models, and AI-enabled scientific workflows.
Medical Monitor/Senior Medical Monitor, Hematology Tessera TherapeuticsMedical Monitor/Senior Medical Monitor, HematologySomerville, MA$270,000–$335,000 / yearMinimum 3 years of biotechnology or pharmaceutical industry experience in clinical development with direct experience serving as a Medical Monitor for interventional clinical studies, or extensive academic expertise as a Principal Investigator of hematology/oncology clinical trials with a demonstrated track record of publications. Reporting to the Chief Medical & Development Officer, the Medical Monitor will play a critical role in the design, conduct, and interpretation of early-stage clinical trials for novel genomic medicines targeting hematologic diseases, with indications that may include sickle cell disease and hematologic malignancies.
NewSenior Director, Computational Drug Discovery (Dk/Us) Zealand Pharma A/SSenior Director, Computational Drug Discovery (Dk/Us)Cambridge, MA$223,000–$300,000 / yearAs a technical leader, you bring credibility to guide and coach your team through hands-on expertise in at least two of the following areas: Structure prediction & modeling: co-folding and structure prediction, homology and complex modeling, and integration with experimental cryo-EM and X-ray data, with rigorous evaluation of confidence metrics and their limitations, applied to antibody (CDR-loop prediction, paratope/epitope analysis) and peptide/macrocyclic design, as well as target assessment and draggability. Structure and ligand-based drug design: docking and physics-based modeling (MD, FEP/TI, QM/MM) for relative and absolute binding, with rigorous understanding of the applicability domains of different methods and how to combine approaches where any single method falls short, plus sequence-activity modeling, permeability and half-life analysis for peptides, and embeddings for peptide sequence space.
Medical Monitor/Senior Medical Monitor, Hematology Tessera Therapeutics IncMedical Monitor/Senior Medical Monitor, HematologySomerville, MA$270,000–$335,000 / yearMinimum 3 years of biotechnology or pharmaceutical industry experience in clinical development with direct experience serving as a Medical Monitor for interventional clinical studies, or extensive academic expertise as a Principal Investigator of hematology/oncology clinical trials with a demonstrated track record of publications. Reporting to the Chief Medical & Development Officer, the Medical Monitor will play a critical role in the design, conduct, and interpretation of early-stage clinical trials for novel genomic medicines targeting hematologic diseases, with indications that may include sickle cell disease and hematologic malignancies.