NewScientist/Senior Scientist for Pharmacology BiocytogenScientist/Senior Scientist for PharmacologyWaltham, MA$100,000–$110,000 / yearFull timeBiocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology. The successful candidate will be a critical member of our fast-paced and expanding CRO team, actively engaging in both hands-on experimental work and strategic project management to support biotech and pharmaceutical partners.
Director, Clinical Pharmacology Alkermes PlcDirector, Clinical PharmacologyWaltham, MAIn 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts' Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.
Senior Director, Clinical Pharmacology Vertex Pharmaceuticals IncSenior Director, Clinical PharmacologyBoston, MA$232,000–$348,000 / yearThe role's responsibilities will include maintaining organizational processes across the group, influencing clinical program strategy, and integrating activities with other departments across the Global Research and Development organization, to help shape innovative and integrated clinical development plans. Manages a group of Clinical Pharmacologists at Director-level and below to set strategy, develop and execute Clinical Pharmacology plans and studies for Disease Area programs.
NewResearch Leader / Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA Isomorphic LabsResearch Leader / Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MACambridge, MAThese are exciting opportunities to work closely with world-leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. These roles are ideal for experienced in vitro pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays, and extensive experience of providing quantitative in vitro pharmacology expertise within drug discovery projects.
Associate Director, Quantitative System Pharmacology Viridian Therapeutics IncAssociate Director, Quantitative System PharmacologyWaltham, MARemoteQualifications: Requires a PhD degree or equivalent with a minimum of 6+ years of combined academic and biotechnology or pharmaceutical experience in QSP/T, (m)PBPK, mathematics, chemical/biomedical engineer, physics, and/or Translational Sciences, including experience with therapeutic antibodies. Experience with QSP or (m)PBPK modeling in autoimmune or inflammation for biologicals (ie, monoclonal antibodies, or other modalities), and bring forward combination drug approaches leveraging QSP models to advance clinical trials.
Senior Scientist In vitro / Cellular Pharmacology, Cambridge, MA Isomorphic Labs LimitedSenior Scientist In vitro / Cellular Pharmacology, Cambridge, MACambridge, MAThis is an exciting opportunity to work closely with world-leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. Act as a vital bridge between computational prediction and experimental reality, collaborating closely with: AI/ML and Data Science teams: To translate in silico predictions into testable hypotheses and provide clean data loops to train future models.
Associate Director, Quantitative Systems Pharmacology GSK plcAssociate Director, Quantitative Systems PharmacologyWaltham, MA$151,500–$252,500 / yearAs an Associate Director of Quantitative Systems Pharmacology (QSP) Expert, you will develop and apply QSP models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas. This role requires a highly motivated individual to develop and apply QSP models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas.
Scientist I/Ii, Bioanalytical (Lc-Ms) Tessera TherapeuticsScientist I/Ii, Bioanalytical (Lc-Ms)Somerville, MA$109,000–$143,000 / yearDevelop, optimize, and validate bioanalytical methods to measure proteins, oligos, and lipids in biological samples, including cells, biofluids, and tissues, to support the development of discovery, preclinical and clinical programs. Company Summary: Tessera Therapeutics is pioneering Gene Writing- a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source.
Medical Monitor/Senior Medical Monitor, Hematology Tessera TherapeuticsMedical Monitor/Senior Medical Monitor, HematologySomerville, MA$270,000–$335,000 / yearMinimum 3 years of biotechnology or pharmaceutical industry experience in clinical development with direct experience serving as a Medical Monitor for interventional clinical studies, or extensive academic expertise as a Principal Investigator of hematology/oncology clinical trials with a demonstrated track record of publications. Reporting to the Chief Medical & Development Officer, the Medical Monitor will play a critical role in the design, conduct, and interpretation of early-stage clinical trials for novel genomic medicines targeting hematologic diseases, with indications that may include sickle cell disease and hematologic malignancies.
Clinical Research Director - Rare Diseases SanofiClinical Research Director - Rare DiseasesCambridge, MA$178,500–$257,833.33 / yearExperience / Skills: MD or MD/PhD in a relevant scientific discipline, preferably pulmonology, with at least 2 years relevant experience in clinical development within the pharmaceutical industry, academia, or government agencies such as the NIH, FDA, or other equivalent national or international public health and regulatory organization. On Clinical Development, the CRD: Designs the global clinical development strategy (in close cooperation with other members of the team, particularly Regulatory Affairs end Health Economics) and leads the clinical development with regard to ongoing development activities and planned LCM for labelling changes.
Clinical Research Director, Rare Diseases SanofiClinical Research Director, Rare DiseasesCambridge, MA$206,250–$343,750 / yearExperience / Skills: MD or MD/PhD in a relevant scientific discipline, preferably pulmonology, with at least 2 years relevant experience in clinical development within the pharmaceutical industry, academia, or government agencies such as the NIH, FDA, or other equivalent national or international public health and regulatory organization. On Clinical Development, the CRD: Designs the global clinical development strategy (in close cooperation with other members of the team, particularly Regulatory Affairs end Health Economics) and leads the clinical development with regard to ongoing development activities and planned LCM for labelling changes.
Associate Director, Discovery DMPK Parabilis MedicinesAssociate Director, Discovery DMPKCambridge, MA$165,000–$200,000 / yearIts lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between ß-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/ß-catenin-driven tumors. Reporting to the VP of Discovery DMPK, you will serve as the primary DMPK representative on cross-functional discovery project teams, collaborating closely with medicinal chemists, pharmacologists, toxicologists and external CRO partners to advance novel therapeutics from early discovery through DC nomination.
Associate Director, Pharmacology Formation BioAssociate Director, PharmacologyBoston, MA$177,500–$232,000 / yearManage CRO-executed pharmacology studies and related workflows, including protocol review, vendor oversight, data quality, timelines, budgets, study conduct, interpretation, final reports, organizational tracking systems, and use of technology, modeling, data analytics, literature mining, and AI-enabled tools to improve speed, rigor, reproducibility, and decision-making. This role is well suited for a scientifically rigorous, intellectually independent pharmacologist who can move fluidly across mechanisms, modalities, disease areas, and stages of development, with particular value placed on familiarity with immunology, animal models, and AI-enabled scientific workflows.
Scientist I/II, Bioanalytical LC-MS Tessera Therapeutics IncScientist I/II, Bioanalytical LC-MSSomerville, MA$109,000–$143,000 / yearDevelop, optimize, and validate bioanalytical methods to measure proteins, oligos, and lipids in biological samples, including cells, biofluids, and tissues, to support the development of discovery, preclinical and clinical programs. Company Summary: Tessera Therapeutics is pioneering Gene Writing- a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source.
Medical Monitor/Senior Medical Monitor, Hematology Tessera Therapeutics IncMedical Monitor/Senior Medical Monitor, HematologySomerville, MA$270,000–$335,000 / yearMinimum 3 years of biotechnology or pharmaceutical industry experience in clinical development with direct experience serving as a Medical Monitor for interventional clinical studies, or extensive academic expertise as a Principal Investigator of hematology/oncology clinical trials with a demonstrated track record of publications. Reporting to the Chief Medical & Development Officer, the Medical Monitor will play a critical role in the design, conduct, and interpretation of early-stage clinical trials for novel genomic medicines targeting hematologic diseases, with indications that may include sickle cell disease and hematologic malignancies.
NewSenior Director, Clinical Pharmacology Amylyx Pharmaceuticals IncSenior Director, Clinical PharmacologyCambridge, MARemote$268,000–$302,000 / yearThe Senior Director, Clinical Pharmacology is a highly experienced clinical pharmacologist who will provide strategic scientific leadership across multiple development programs from Phase 1 through Phase 3. Reporting to the Vice President, Clinical Pharmacology, this individual will partner with cross-functional program teams to develop and execute clinical pharmacology strategies that support regulatory submissions and successful drug development. The successful candidate will work collaboratively with Clinical Development, Biometrics, Regulatory Affairs, Translational Medicine, Nonclinical, Medical Writing, and external partners to ensure robust clinical pharmacology strategies throughout development.
PKPD Principal Scientist Metrum Research GroupPKPD Principal ScientistMA$235,000–$295,000We are seeking individuals with 10+ years of postdoctoral experience who thrive in collaborative, agile environments and are passionate about advancing modeling and simulation approaches that drive meaningful impact for clients and patients. D. degree in a scientific discipline (pharmaceutical sciences, pharmacokinetics, mathematics, statistics, biomedical engineering or a related field) or Master's degree with relevant experience, or equivalent.
Senior Scientist, Computational Biology - Contract Tessera TherapeuticsSenior Scientist, Computational Biology - ContractSomerville, MA$74–$80 / hourHis group supports drug candidate programs through genotoxicity risk assessment, develops computational approaches to study gene writing biology, and builds scalable data and analysis infrastructure to support molecular assay design and knowledge mining. Broad knowledge of genome editing technologies and associated off-target discovery assays (i.e. WGS; targeted sequencing; GUIDE-seq, Digenome-seq discovery / verification; large and small structural variations and translation effects; NGS QC).
Vice President, Corporate Transactions Tessera TherapeuticsVice President, Corporate TransactionsSomerville, MA$269,000–$345,000 / yearAs a key member of the Legal Leadership team, you will lead and support a broad range of corporate matters, including SEC and Nasdaq compliance, capital markets activities, business development transactions, external communications, contracting, and governance initiatives. Working closely with the General Counsel, Human Resources, Finance, and others on matters related to the Board of Directors and its committees, including drafting resolutions and minutes, and attend meetings according to business needs.
Director, Head Of Program Management Tessera TherapeuticsDirector, Head Of Program ManagementSomerville, MA$186,000–$239,000 / yearGuiding and empowering Program Managers to drive the development and management of integrated program plans (including timelines, assumptions, scenarios, risks, critical path, decision maps, goals, and budget drivers). Company Summary: Tessera Therapeutics is pioneering Gene Writing- a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source.