Senior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics Johnson & JohnsonSenior Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/PharmacodynamicsSpring House, PA$137,000–$235,750 / yearModeling approaches used may include physiologically-based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c) guide in vivo and in vitro experimental designs that will be most informative for modeling. Required Skills: Preferred Skills: Clinical Pharmacology, Clinical Trials Operations, Consulting, Drug Discovery Development, Industry Analysis, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Program Management, Report Writing, Researching, Research Proposals, Scientific Research, Tactical Planning, Technical Credibility.
Principal Agentic Workflow & AI Engineer, Biologics Discovery Johnson & JohnsonPrincipal Agentic Workflow & AI Engineer, Biologics DiscoverySpring House, PA$117,000–$201,250 / yearYou will partner across Discovery, Data Science, In Silico Discovery (ISD), our Enterprise Generative AI team, and our data-infrastructure and lab-automation teams to enable closed-loop feedback so that each experimental cycle improves downstream models and decisions - timed to lab-automation readiness as new automation infrastructure comes online. This role brings agentic AI and intelligent automation to compress cycle time, reduce manual intervention, and improve reproducibility - transforming today's hands-on processes into scalable, connected, intelligent discovery workflows.
Principal Scientist, In-Vivo Car-T Potency Method Development Johnson & JohnsonPrincipal Scientist, In-Vivo Car-T Potency Method DevelopmentMalvern, PARequired Skills: Preferred Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Principal Product Manager, Risk & Fraud Circle Internet Financial LLCPrincipal Product Manager, Risk & FraudPhiladelphia, PARemote$200,000–$260,000 / yearDefine the strategy and roadmap for a risk and fraud platform that supports real-time and asynchronous risk decisions across products and markets that supports crypto- and traditional financial rails, as well as risk-related use cases across onboarding, account linking, and other customer lifecycle events - with a focus on building a user-friendly rules engine and intuitive tooling for risk operators. Build fraud prediction and detection systems from the ground up by defining risk vectors affecting Circle's product roadmap and executing mitigating controls to address them by integrating party vendor models, and creating iterative feedback loops that learn from past fraudulent behavior.
Principal Specialist, Regulatory Affairs West Pharmaceutical Services IncPrincipal Specialist, Regulatory AffairsExton, PAWest solved the problem of supplying penicillin in mass quantities to the US Government during World War 2. Through our work to deliver thousands of life-saving and life-enhancing injectable medicines to millions of patients daily, West's indelible mark on the healthcare industry has just begun. In addition, the Principal Specialist mentors team members, and provides support for global regulatory approvals (beyond US and EU), commercialized products, and ensures compliance with West Pharmaceutical Services, Inc. (West) and government requirements.
Principal Solution Architect - Reporting & Analytics West Pharmaceutical ServicesPrincipal Solution Architect - Reporting & AnalyticsExton, PAWest solved the problem of supplying penicillin in mass quantities to the US Government during World War 2. Through our work to deliver thousands of life-saving and life-enhancing injectable medicines to millions of patients daily, West's indelible mark on the healthcare industry has just begun. Act as a subject matter expert in designing and implementing Microsoft Fabric solutions, including Data Engineering, Data Factory, Lakehouse, Warehouse, and Power BI applications to support enterprise dashboards, reports, and analytics.
Principal Product Manager, Onboarding Circle Internet Financial LLCPrincipal Product Manager, OnboardingPhiladelphia, PARemote$200,000–$260,000 / yearCircle's platform includes the world's largest regulated stablecoin network anchored by USDC, Circle Payments Network for global money movement, and Arc, an enterprise-grade blockchain designed to become the Economic OS for the internet. What you'll be part of: Circle is a financial technology company at the epicenter of the emerging internet of money, where value can finally travel like other digital data - globally, nearly instantly and less expensively than legacy settlement systems.
Oil And Gas/Energy Finance Managed Services, Principal Baker Tilly Virchow Krause, LLPOil And Gas/Energy Finance Managed Services, PrincipalPhiladelphia, PABaker Tilly Advisory Group, LP and Baker Tilly US, LLP, trading as Baker Tilly, are independent members of Baker Tilly International, a worldwide network of independent accounting and business advisory firms in 141 territories, with 43,000 professionals and a combined worldwide revenue of $5.2 billion. Baker Tilly is a leading advisory, tax and assurance firm, providing clients with a genuine coast-to-coast and global advantage in major regions of the U.S. and in many of the world's leading financial centers - New York, London, San Francisco, Los Angeles, Chicago and Boston.
Principal Metallurgist - Technology Carpenter TechnologyPrincipal Metallurgist - TechnologyReading, PACarpenter Technology Corporation is a leading producer and distributor of premium specialty alloys, including titanium alloys, nickel and cobalt based superalloys, stainless steels, alloy steels and tool steels. Manages functional project teams to address and solve complex technical problems and recognize business trends for alloy and process development, including project planning and budget compliance.
NewPrincipal, Business Development L3Harris Technologies IncPrincipal, Business DevelopmentCamden, NJ$146,000–$271,000 / yearThis role requires deep subject matter expertise in unmanned undersea vehicles and submarine communications, combined with a strong understanding of business development and capture management processes, including Shipley methodologies. The successful candidate will drive growth within the Autonomous Undersea Vehicle Systems (AUVS) and Submarine Communications portfolios, expanding business opportunities across U.S. and international military and commercial markets.
NewPrincipal Project Manager - Telecommunications, Media, and Technology Microsoft CorpPrincipal Project Manager - Telecommunications, Media, and TechnologyPhiladelphia, PA$124,500–$214,600 / yearDrive project initiation and planning for large, complex customer projects by securing delivery resources, assigning them across workstreams, and creating detailed work breakdown structures in alignment with customer plans. There is a different range applicable to specific work locations, within the San Francisco Bay area and New York City metropolitan area, and the base pay range for this role in those locations is USD $154,500 - $231,700 per year.
NewSystem Integrations Principal IQVIA Holdings IncSystem Integrations PrincipalWayne, PA$138,600–$386,200 / yearDemonstrate deep expertise in at least one of the following domains, with the ability to connect business requirements to system and data implications: Commercial Contracting; Managed Care; Government Pricing; Medicaid; technical architecture and integrations; or automation. Proven ability to create and manage project timelines, integrated project plans, governance structures, communication plans, change management plans, and cross-vendor delivery models.
Sr. Principal Designer, CATS & SPECS Piping KBR IncSr. Principal Designer, CATS & SPECS PipingNewark, DEKBR ISA (Integrated Solutions Americas) delivers integrated, end-to-end engineering, procurement, and construction management services to the refining, LNG, midstream, chemicals, petrochemicals, oil and gas, power, and industrial infrastructure sectors. Required Education, Experience, & Skills: Minimum of 10 years of experience developing and maintaining piping catalogs and specifications for industrial, energy, chemical, refining, LNG, or related projects.
NewCost Segregation Senior Manager/Principal WithumCost Segregation Senior Manager/PrincipalPhiladelphia, PA$150,000–$350,000 / yearAs a strategic leader within the Forensic & Valuation Services Group, this individual will be responsible for driving market growth, developing scalable processes, leading business development initiatives, mentoring team members, and collaborating with firm leadership to expand service offerings and client relationships nationwide. Our Cost Segregation professionals help clients maximize tax savings opportunities through engineering-based analyses of commercial, residential, manufacturing, hospitality, healthcare, and other real estate assets.
Principal Device Engineer Teva Pharmaceutical Industries LtdPrincipal Device EngineerWest Chester, PAYou will lead root cause investigations into issues such as out-of-trend (OOT) high break-loose/extrusion force and injection time failures, while also contributing to the design, verification, and regulatory lifecycle of drug-device combination products under ISO 13485 and 21 CFR Part 4. The ideal candidate has strong mechanical aptitude, working knowledge of biologic drug product and container-closure interactions, and experience with design controls, method validation, and regulatory submissions. Additional benefits include, but are not limited to, Employee Assistance Program, Employee Stock Purchase Plan, Tuition Assistance, Flexible Spending Accounts, Health Savings Account, Life Style Spending Account, Volunteer Time Off, Paid Parental Leave, if eligible, Family Building Benefits, Virtual Physical Therapy, Accident, Critical Illness and Hospital Indemnity Insurances, Identity Theft Protection, Legal Plan, Voluntary Life Insurance and Long Term Disability and more.
Sr. Principal Piping Designer - Cats & Specs KBRSr. Principal Piping Designer - Cats & SpecsNewark, DEKBR ISA (Integrated Solutions Americas) delivers integrated, end-to-end engineering, procurement, and construction management services to the refining, LNG, midstream, chemicals, petrochemicals, oil and gas, power, and industrial infrastructure sectors. Required Education, Experience, & Skills: Minimum of 10 years of experience developing and maintaining piping catalogs and specifications for industrial, energy, chemical, refining, LNG, or related projects.
Principal Regulatory Affairs Project Manager, Medical Devices West Pharmaceutical ServicesPrincipal Regulatory Affairs Project Manager, Medical DevicesExton, PAWest solved the problem of supplying penicillin in mass quantities to the US Government during World War 2. Through our work to deliver thousands of life-saving and life-enhancing injectable medicines to millions of patients daily, West's indelible mark on the healthcare industry has just begun. Ability to assess, plan, schedule and manage multiple long-term and short-term projects, tasks, responsibilities and/or priorities in a concurrent fashion with several parallel deliverables and execute deliverables to time-line commitments.
NewPrincipal Analyst, MAP Financial Industry Regulatory Authority, Inc.Principal Analyst, MAPPhiladelphia, PA$112,300–$202,500 / yearFINRA employees are required to disclose to FINRA all brokerage accounts that they maintain, and those in which they control trading or have a financial interest (including any trust account of which they are a trustee or beneficiary and all accounts of a spouse, domestic partner or minor child who lives with the employee) and to authorize their broker-dealers to provide FINRA with duplicate statements for all of those accounts. Additional insurance includes basic life, accidental death and dismemberment, supplemental life, spouse/domestic partner and dependent life, and spouse/domestic partner and dependent accidental death and dismemberment, short- and long-term disability, long-term care, business travel accident, disability and legal.
NewPrincipal Data Engineer, Biologics Discovery Johnson & JohnsonPrincipal Data Engineer, Biologics DiscoverySpring House, PA$117,000–$201,250 / yearThis role provides senior technical leadership within Biologics Discovery, translating scientific needs into data products, scientific data models, and requirements, and working with enterprise data and technology partners to ensure discovery data is trusted, connected, and AI-ready as the broader ecosystem evolves. Deep proficiency in Python and SQL, with hands-on experience designing and implementing reusable and scalable data assets on cloud data platforms (e.g., Snowflake, AWS, Azure, BigQuery) to support analytics, machine learning, and AI-driven workflows.
NewPrincipal Specialist - IT ETRM Systems Dev NuStar Energy LPPrincipal Specialist - IT ETRM Systems DevNewtown Square, PAThis critical infrastructure complements the Partnership's fuel distribution operations, which distribute over 15 billion gallons annually to approximately 11,000 Sunoco and partner-branded retail locations, as well as independent dealers and commercial customers. Sunoco LP is a leading energy infrastructure and fuel distribution master limited partnership operating across 32 countries and territories in North America, the Greater Caribbean, and Europe.