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Principal Jobs in Wilmington, MA

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Principal Software Engineer, Payer Portal Athenahealth

Boston, MA

$164,000–$280,000 / year

Based in Boston, MA with a hybrid work arrangement, this role partners with product, architecture, and engineering teams to solve complex revenue cycle challenges using distributed systems, Java, Spring Boot, AWS, Kubernetes, and related technologies. We offer IT solutions and expert services that eliminate the daily hurdles preventing healthcare providers from focusing entirely on their patients — powered by our vision to create a thriving ecosystem that delivers accessible, high-quality, and sustainable healthcare for all.

4 days ago

Principal ML Platform Engineer - Remote Appian Corporation

Boston, MA

Remote

$175,000–$325,000 / year

Growth Opportunities: Appian provides a diverse array of growth and development opportunities, including our leadership program tailored for new and aspiring managers, a comprehensive library of specialized department training through Appian University, skills based training, and tuition reimbursement for those aiming to advance their education. Equipped with cutting-edge AI tooling, you will drive the design and delivery of high-complexity engineering solutions, set the technical bar for the team, and lead other engineers towards solutions of real complexity to ensure flawless Enterprise-Grade Orchestration.

1 day ago

Principal Scientist, Vaccine Virology CSL Seqirus

Waltham, MA

$145,000–$180,000 / year

Techniques may include live-virus and pseudovirus neutralization, infectious-virus culture and titration, plaque and focus-forming assays, TCID50, RT-qPCR, reverse genetics, hemagglutination inhibition (HAI), microneutralization, ELISA, neuraminidase inhibition, and functional antibody assays such as antibody-dependent cellular cytotoxicity (ADCC). Reporting to the Director, Vaccine Virology & Immunology, you will provide scientific leadership and hands-on laboratory expertise to advance seasonal and pandemic influenza vaccines, support existing products, and evaluate new respiratory-virus vaccine opportunities.

5 days ago

Principal Data Engineer (Service) Waters Corporation

Milford, MA

Design and build scalable, reliable data platforms that integrate service delivery data (work orders, cases, products, geography), service team member data (roles, locations, workloads), service revenue and cost data, and proforma P&L information to enable strategic decision-making. You will bring deep technical expertise in service business data domains, operate with a high degree of independence, and contribute to the design and delivery of scalable data platforms that enable strategic decision-making for revenue growth, margin expansion, and operational excellence initiatives targeting $200M+ in EBIT improvement.

1 day ago

Senior Principal Enterprise Architect Waters Corporation

Milford, MA

As a senior individual contributor with broad influence, the Principal Enterprise Architect will operate at the intersection of business strategy and technology execution—guiding complex architectural decisions, enabling large scale integration programs, and ensuring that near term transformation choices support long term scalability, resilience, and value creation. This role is responsible for shaping Waters’ long term technology direction while playing a critical leadership role in the integration of BD businesses, platforms, and data into the Waters ecosystem.

1 day ago

Principal Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial or service processes), with the ability to translate business processes into scalable data solutions. The Principal Data Engineer designs, builds, and enhances robust data pipelines and platforms that support analytics, machine learning, and operational monitoring.

1 day ago

Principal AI Solutions Engineer Waters Corporation

Cambridge, MA

The successful candidate will partner with scientists and engineers across the research organization to identify high-value use cases, configure AI-enabled workflows, and scale approaches that improve productivity, accelerate discovery, and increase innovation yield in domains where AI has not traditionally been applied. Waters Global Research organization advances the analytical instruments, chemistries, and software that laboratories worldwide rely on to characterize molecules with exceptional precision — from biopharmaceuticals to the safety of the food and water supply.

1 day ago

Senior Principal Scientist Waters Corporation

Milford, MA

In addition to leading innovation in material design, you will help advance next-generation manufacturing strategies for Waters particle and bonded-phase production, including scalable and data-rich manufacturing approaches, advanced process characterization, and in-process analytical testing methodologies. As a Senior Principal Scientist within the BioSeparations Portfolio of the Chemistry & Lab Automation Business Unit, you will define and lead the scientific strategy for novel chromatographic materials and enabling chemistries for biologics ranging from oligonucleotides, viral vectors, and mRNA to proteins, peptides, and gene-editing therapeutics.

1 day ago

Principal AI Security Analyst Waters Corporation

Milford, MA

We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance. You will lead the security review of AI/ML systems, manage our AI security toolchain, identify emerging threats unique to large-scale models, and build the frameworks that keep our AI infrastructure resilient against adversarial attacks.

1 day ago

Research Principal Scientist Waters Corporation

Milford, MA

Design materials with optimized specific applications in reversed-phase, Ion-exchange, HILIC, affinity, mixed-mode, and sample preparation workflows for separations of proteins, monoclonal antibodies, oligonucleotides, peptides, PFAS, and small molecules. Members of Global Research work in highly collaborative cross-functional teams spanning Consumables, Liquid Chromatography, Mass Spectrometry, Clinical, and Informatics technologies to develop novel solutions for complex analytical problems.

1 day ago

Principal Pricing Data Engineer Waters Corporation

Milford, MA

Strong business domain knowledge and experience working with enterprise systems such as SAP (e.g., supply chain data, orders, revenue recognition, pricing), Salesforce (commercial operations), and/or Service Excellence domains, with the ability to translate business processes into scalable data solutions. We collaborate with customers around the world to advance the release of effective, high-quality medicines, ensure the safety of food and water, and drive better patient outcomes by detecting diseases earlier, managing routine infections, and combating antibiotic resistance.

1 day ago

Principal Program Manager Waters Corporation

Milford, MA

The role serves as the primary business-facing lead for PLM delivery, working closely with stakeholders, IT teams, implementation partners, and senior leaders to ensure PLM capabilities support business priorities, regulatory expectations, operational efficiency, and product data governance. This role combines practical program leadership with strong PLM business process knowledge to deliver scalable solutions across Engineering, Quality, Manufacturing, Regulatory Affairs, Supply Chain, IT, and ERP-connected processes.

1 day ago

Principal Product Manager - Remote Circle

Boston, MA

Remote

$197,500–$240,833 / year

You will identify the highest-value customer problems and emerging use cases, establish a coherent strategy across custodial, developer-controlled, user-controlled, agentic, institutional custody, and cold-storage wallet models, and translate that strategy into differentiated products that drive customer adoption and business impact. Drive platform investments that accelerate chain expansion, reduce the cost and complexity of launching new wallet use cases, and improve reliability across EVM, non-EVM, hard-fork, and protocol-upgrade workflows.

14 days ago

Principal Product Manager, Risk & Fraud - Remote Circle

Boston, MA

Remote

$200,000–$260,000 / year

Define the strategy and roadmap for a risk and fraud platform that supports real-time and asynchronous risk decisions across products and markets that supports crypto- and traditional financial rails, as well as risk-related use cases across onboarding, account linking, and other customer lifecycle events — with a focus on building a user-friendly rules engine and intuitive tooling for risk operators. Build fraud prediction and detection systems from the ground up by defining risk vectors affecting Circle’s product roadmap and executing mitigating controls to address them by integrating party vendor models, and creating iterative feedback loops that learn from past fraudulent behavior.

14 days ago

Principal Software Engineer I - Serverless - Platform Control Plane Elastic

Boston, MA

8+ years building software, including setting technical direction for complex distributed systems running production at scale (Staff or Principal level, or equivalent scope). By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Software Engineer - Storage Engine Elastic

Boston, MA

Remote

This globally distributed, fully remote team of experienced engineers develops core storage and query technologies for observability workloads, including improving storage efficiency, advancing ES|QL query processing and performance, and optimizing data layouts for object storage. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Software Engineer - Search Infra Elastic

Boston, MA

This role provides technical vision and direction for Elasticsearch’s core search infrastructure, including indexing, retrieval, and relevance, and requires deep expertise in search internals and cross-team collaboration. By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI.

1 day ago

Principal Software Engineer - Security Elastic

Boston, MA

By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. • You have a solid comprehension of distributed systems security, including node-to-node mutual trust, zero-trust transport, partition tolerance, and cluster state propagation.

1 day ago

Principal Product Manager, Arc Consumer - Remote Circle

Boston, MA

Remote

$225,000–$276,667 / year

You’ll own the product strategy and roadmap for Arc’s consumer experience and work across Design, Engineering, Data, and the broader Circle organization to turn powerful onchain capabilities (like privacy and interoperability) into products that feel intuitive, trustworthy, and delightful. Circle’s platform includes the world’s largest regulated stablecoin network anchored by USDC, Circle Payments Network for global money movement, and Arc, an enterprise-grade blockchain designed to become the Economic OS for the internet.

14 days ago

Principal Software Engineer - Performance Tuning Elastic

Boston, MA

By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. This includes deep experience with benchmarking tools (e.g., flamegraphs, JMH, Rally), identifying performance regressions, and implementing algorithmic or hardware-aware optimizations.

1 day ago

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Principal Jobs in Wilmington, MA

Principal Software Engineer, Payer Portal Athenahealth

Principal ML Platform Engineer - Remote Appian Corporation

Principal Scientist, Vaccine Virology CSL Seqirus

Principal Data Engineer (Service) Waters Corporation

Senior Principal Enterprise Architect Waters Corporation

Principal Data Engineer Waters Corporation

Principal AI Solutions Engineer Waters Corporation

Senior Principal Scientist Waters Corporation

Principal AI Security Analyst Waters Corporation

Research Principal Scientist Waters Corporation

Principal Pricing Data Engineer Waters Corporation

Principal Program Manager Waters Corporation

Principal Product Manager - Remote Circle

Principal Product Manager, Risk & Fraud - Remote Circle

Principal Software Engineer I - Serverless - Platform Control Plane Elastic

Principal Software Engineer - Storage Engine Elastic

Principal Software Engineer - Search Infra Elastic

Principal Software Engineer - Security Elastic

Principal Product Manager, Arc Consumer - Remote Circle

Principal Software Engineer - Performance Tuning Elastic

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