246 Results for

Principal Jobs in Winchester, MA

Jobs

Billerica, MA13 days ago

Drive product development from concept through manufacturing, including: System architecture and conceptualization. Ability to innovate and apply new technologies or existing methods to solve complex design challenges.

Weymouth, MA21 days ago

$120,000–$150,000 Per Year
Full-time
Employee

Write and analyze test plans, execute tests and evaluate test results to demonstrate the design meets specifications with high quality. Develop assembly processes and instructions using lean principles to safely reduce waste, increase efficiency, and improve product quality.

New!

Bedford, MA4 days ago

$123,639–$145,000 Per Year

Command, Control, Communications, and Battle Management (C3BM) has been tasked with delivering an integrated Department of the Air Force (DAF) Battle Network providing resilient decision advantage and enabling the USAF, USSF, Joint, and Coalition Force to win against the pacing challenge. C3BM’s main efforts are Architecture and Systems Engineering (ASE), Operational Response Team (ORT), and multiple mission integration teams such as Air, Maritime and multiple acquisitions consisting of both the Advanced Battle Management System (ABMS) and Space.

Quincy, MA13 days ago

$165,500–$234,700

Saab Inc., Autonomous and Undersea Systems division is seeking an innovative and experienced Principal Mechanical Engineer to guide others on technical teams in capturing, understanding, and implementing product design requirements for autonomous Unmanned Surface/Underwater Vehicles (aUSVs/aUUVs, AUVs) and Remotely Operated Vehicles (ROVs). Demonstrated performance and expertise in the elements of mechanical design, such as analysis and implementation of requirements, developing design concepts, evaluating designs, technical and design reviews.

New!

Boston, MAToday

$160,739–$200,924 Per Year

Minimum qualifications: Master’s degree in Operations Research, Data Science, Statistics, Applied Mathematics, Engineering, Computer Science or related field; 5 years in quantitative pricing/financial analysis. Demonstrated ability to frame complex problems, select appropriate research/analytical methods, implement solutions, and present findings effectively.

New!

Cambridge, MA1 day ago

Remote

Full-time
Employee

A successful candidate will assist ASIC development through creating custom analog layouts, floor planning entire chips, high level problem solving, and executing tape outs. ¿ Perform or guide physical layout, including floor-planning, and simulate circuits using extracted parasitic, contribute to design-for-test development.

Boston, MA9 days ago

Mentor and Scale Field Teams: Act as a thought leader within the organization, mentoring Solutions Consultants and Forward Deployed Engineers and helping to evolve and refine our AI solution delivery best practices. • Influence Product and GTM Strategy: Collaborate closely with product and engineering teams to relay field insights, identify gaps in our prebuilt agent inventory, and influence the product roadmap based on strategic customer needs.

Boston, MA11 days ago

By taking advantage of all structured and unstructured data — securing and protecting private information more effectively — Elastic’s complete, cloud-based solutions for search, security, and observability help organizations deliver on the promise of AI. For example, Debugging Azure Networking for Elastic Cloud Serverless is part of our efforts, and we want your experience to contribute to a truly exceptional customer experience.

New!

Woburn, MA3 days ago

Full-time
Employee

Client is focused on delivering National Defense capabilities by driving mission-focused strategies to develop advanced technology systems enabling enduring products and solutions focused on achieving the customer vision. Applicants are expected to be self-motivated, detail oriented and have a demonstrated ability to effectively communicate with all levels of management and individual contributors on the program team through strong written and verbal communication skills.

Andover, MA13 days ago

Translate engineering design requirements into formal manufacturing process documentation including raw material definition, fixturing/tooling development, CNC programming, inspection planning, finishing requirements, and assembly instructions. Qualifications You Must Have: * Typically requires a Bachelor's Degree in Manufacturing Engineering, Mechanical Engineering, Industrial Engineering, Electrical Engineering, or Aerospace Engineering.

Boston, MA11 days ago

Drive design and implementation of small-scale applications and proof of concepts to improve risk analysis, develop AI-enabled workflows, and enhance reporting systems and processes. Work closely with risk analysts and investment teams to build robust systems and tools that power risk infrastructure, analytics, and decision-ready reporting.

Boston, MA11 days ago

New!

Boston, MAToday

$162,773.52–$207,541.52

A management role that supervises employees focusing on tactical, operational activities within a specified area, with the majority of time spent overseeing area of responsibility, planning, prioritizing and/or directing the responsibilities of employees. Individual offers are determined using a comprehensive approach that considers relevant experience, certifications, education, skills, and internal equity to ensure compensation is fair, consistent, and aligned with our business goals.

Lancaster, MA30+ days ago

Must assist in enforcing the school code of conduct, testing and assessment programs, preparation of student and class schedules, assist all custodial, cafeteria, and other support services, assist in all curriculum matters. Assist parents through prompt communication and support for the purpose of impacting and improving students' academic performance.

Boston, MA30+ days ago

Assists the administration in implementing all policies and rules governing student life and conduct, and for the classroom, develops reasonable rules of classroom behavior and procedure, and maintains order in the classroom in a fair and just manner. Employs a variety of instructional techniques and instructional media, consistent with the physical limitations of the location provided and the needs and capabilities of the individuals or student groups involved.

Boston, MA30+ days ago

General Description: Under the general supervision, serves as secretary to the principal or headmaster of a school; performs complex clerical work requiring exercise of independent judgment. Email: hiringprocess@bostonpublicschools.org.

Andover, MA30+ days ago

$112,700–$187,800 Per Year

Team leader responsible for the safety and oversight of Technical Programs laboratory-based and at-scale work, including small-scale cleaning validation program requirements, mixing qualification, and solution chemical stability and expiry. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.

New!

North Reading, MA1 day ago

$219,900–$351,900 Per Year

Teradyne is a global leader in automated test equipment and industrial automation, enabling customers across the semiconductor, electronics, and advanced manufacturing ecosystem to accelerate innovation and deliver high-quality products at scale. Across semiconductor test, system-level and wafer-level test, photonics, and adjacent semiconductor capital equipment, Teradyne operates at the intersection of deep engineering, complex supply chains, and long investment cycles.

Natick, Massachusetts30+ days ago

$200,000–$300,000 Per Year

Boston, MA30+ days ago

Full-time

ODAIA's SaaS platform transforms complex data into predictive, personalized insights, enabling commercial leaders to understand their customers, anticipate prescribing behaviors, and make the informed, strategic decisions that bring therapies to patients faster. A proven track record of building successful partnerships, advising commercial pharma executives, leading high-stakes conversations and influencing multi-million dollar commercial investment decisions through data-driven storytelling.

Andover, MA15 days ago

Translate engineering design requirements into formal manufacturing process documentation including raw material definition, fixturing/tooling development, CNC programming, inspection planning, finishing requirements, and assembly instructions. Typically requires a Bachelors Degree in Manufacturing Engineering, Mechanical Engineering, Industrial Engineering, Electrical Engineering, or Aerospace Engineering.

Boston, MA30+ days ago

We focus all of our energy on discovering and solving customer and business problems, designing financially strong and defensible business models, activating growth engines, hiring world-class founding teams, and helping them thrive (and none of our energy on big-company b.s.). Led by co-founders who have both built unicorn real estate tech companies from scratch, we're a tight team of engineers, product managers, designers, and operators with decades of experience building products, teams, and businesses from startup to scale.

BURLINGTON, MA30+ days ago

Remote

We are seeking a Principal Consultant – Aviation Noise to join our team in a remote or hybrid position in the U.S. In this senior role, you will serve as a recognized technical expert in aviation noise, leading large and complex projects, supervisingand mentoringstaff, shaping practice strategy, and expanding HMMH’s presence in the aviation noise field. Our Aviation Environmental & Sustainability Group supports over 200 airports worldwide with noise and air quality studies, sustainability plans, mitigation strategies, environmental documentation, and regulatory compliance.

New!

Waltham, MA5 days ago

$120,000–$160,000 Per Year

Nova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. With headquarters in Norwood and Waltham, Massachusetts, and a global team of nearly 2,000 employees, we’re building a collaborative, empowered culture grounded in shared values: Customer Centricity, Ingenuity, Ownership & Accountability, Collaboration, and Integrity.

New!

Waltham, MA5 days ago

$155,000–$190,000 Per Year

Nova Biomedical is proud to be a global leader in osmolality testing and biotechnology and in vitro diagnostic (IVD) instrumentation, dedicated to advancing patient care and scientific discovery with a legacy that continues to shape the future of life sciences. Lead system-level analysis and risk mitigation strategies related to battery thermal behavior and heat dissipation, including charging scenarios, environmental extremes, and long-term reliability to ensure patient safety and regulatory compliance.

Waltham, MA15 days ago

We are looking for an experienced researcher to join our team as Principal Research Associate/Associate Scientist in the Molecular Assembly team, supporting our novel target identification and validation workflow in house. Excellent written and verbal communication skills, with the ability to document experiments in an organized and timely fashion and to present scientific data to coworkers.

Boston, MA27 days ago

$150,000–$180,000 Per Year

The client is an innovative connected‑fitness company that blends advanced hardware, immersive digital content, and intuitive software to deliver a premium at‑home training experience, while fully owning and leading the entire electrical design function across its product portfolio. The position owns the entire electrical engineering function, working closely with mechanical, firmware, and software teams to deliver high‑quality, scalable consumer products.

Boston, MA28 days ago

$150,000–$180,000 Per Year
Full-time

Client Details The client is an innovative connected‑fitness company that blends advanced hardware, immersive digital content, and intuitive software to deliver a premium at‑home training experience, while fully owning and leading the entire electrical design function across its product portfolio. The position owns the entire electrical engineering function, working closely with mechanical, firmware, and software teams to deliver high‑quality, scalable consumer products.

Lancaster, MA30+ days ago

The job of Principal - Elementary was estabished for the purpose/s of providing support to the instructional process with specific responsibility for directing overall site operations, services and staff at an elementary school; providing information and serving as a resource to others; enforcing established policies and regulatory requirements; coordinating school activities and addressing issues, situations and/or problems that arise on campus or with enrolled students. Minimum requirements: Master's degree, or higher in job related area, two years of administrative experience as well as five (5) years as a teacher preferred.

Boston, MA30+ days ago

$164,800–$206,000 Per Year

This role is the linchpin connecting cutting-edge technology with transformative workforce solutions, directly shaping products that empower businesses to hire, pay, and manage global teams seamlessly. Strategically leverage AI to create novel software solutions that tackle complex global workforce management and compliance issues, utilizing the Partner ecosystem to showcase and validate platform capabilities.

New!

Boston, MA3 days ago

$90–$95

Experience with DLP, Encryption, Tokenization & HSM-based Key ManagementNotePreferred Qualifications: Experience in financial services, telecom, or government sectors. Experience Needed: 15+ YearsKey Skills Required: 10+ years in Cybersecurity Architecture & Engineering.

Somerville, MA, MA30+ days ago

Full-time

Create conceptual techno-economic on-site energy solutions that appreciate and address the complex customer pain points of energy cost, sustainability, reliability, resilience, Capex constraints, and risk management (includes detailed data analysis, conceptual design, and modelling). The Principal Solutions Architect Engineer will also work with Schneider Electric (SE) Microgrid Competency Center (MGCC), Energy and Sustainability Services (ESS), and other SE business units as well as The Carlyle Group, various generation firms, and Engineer Procure Construct (EPC) firms.

Burlington, MA30+ days ago

Powered by trillions of lines of code scans and a proprietary AI-generated remediation engine, the Veracode platform is trusted by organizations worldwide to build and maintain secure software from code creation to cloud deployment. Strong understanding of various machine learning algorithms, including supervised and unsupervised learning, reinforcement learning, and neural networks.

Burlington, MA30+ days ago

Powered by trillions of lines of code scans and a proprietary AI-generated remediation engine, the Veracode platform is trusted by organizations worldwide to build and maintain secure software from code creation to cloud deployment. This role is ideal for an experienced professional who thrives in designing and maintaining scalable, secure, and cost-efficient CI/CD pipelines, Kubernetes clusters, and cloud-based systems.

Waltham, MA30+ days ago

Full-time

Working knowledge of advanced consulting methodologies, tools, and techniques – with focus on: leveraging AI, LLMs, and life sciences real-world data, for purposes such as patient finding, HCP segmentation, and other applications of advanced analytics, optimization of omnichannel plans, marketing mix, performance analytics and reporting related activities. 10+ years as a top performer within a top-tier biopharmaceutical / pharmaceutical strategy consulting firm serving industry leading clients and/or relevant experience with advanced analytics, omnichannel measurement, marketing analytics, and/or technology-enabled solutions within pharma and biotech.

Bedford / Hanscom AFB, Massachusetts30+ days ago

Bedford / Hanscom AFB, Massachusetts21 days ago

$140,000–$150,000 Per Year

The Air Force Program Execution Office for PEO Electronic Systems (ES) has the collective Air Force Materiel Command (AFMC) mission responsibility to manage and execute the modernization, development, testing, production, fielding, and sustainment of the PEO Digital portfolio, which includes over 130 programs for the United States Air Force (USAF) and foreign allies. Astrion has an exciting opportunity for a PRINCIPAL LOGISTICS MANAGERproviding support to the Air Force Life Cycle Management Center (AFLCMC), PEO Electronic Systems (ES) located at HANSCOM AFB, MA.

Bedford / Hanscom AFB, Massachusetts30+ days ago

Astrion has an exciting opportunity for a Principal Data Links and Communications Engineerfor the EPASS Cyber and Networks Directorate (EPASS HN II) contract, supporting the Aerial Networks Division (AFLCMC/HNA) located at Hanscom AFB, MA. Support defining and documenting a set of Combat Net Radio (CNR) networking parameter configurations to provide the best balance between flexible implementation of capability and implementation impact on both existing and emerging weapon systems.

Boston, MA27 days ago

Remote

Full-time

We are a rapidly growing, Boston-based medical technology company using AI to help clinicians make more informed decisions on cardiovascular care - leading to better patient outcomes, improved quality of care, and reduced healthcare costs. Compensation will be influenced by a wide array of factors including but not limited to internal pay equity, job-related knowledge, skills, education, relevant experience, certifications, and geography as outlined in the job description.

Woburn, MA23 days ago

$140,000–$230,000 Per Year

One or more of the following credentials: certified public accountant (CPA), certified valuation analyst (CVA), accredited in business valuation (ABV), chartered financial analyst (CFA), certified business appraiser (CBA), accredited senior appraiser (ASA), certified divorce financial analyst (CDFA) CPA, CVA, ABV, CBA, or ASA certification is required 10+ years' of recent experience in a related field, with a proven ability to lead and develop client relationships. Proactively identifies and communicates issues to clients, provides value added advice; is viewed as a qualitative and quantitative resource for partners and staff to resolve issues within practice segments and/or industry specialization(s).

Cambridge Crossing, MA30+ days ago

$156,180–$189,252 Per Year

Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to execute in vivo workflows enabling candidate selection for early clinical development is highly desired. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to complex projects.

Devens, MA30+ days ago

$124,590–$151,000 Per Year

Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Build effective relationships/partnerships and work cross-functionally with internal and external stakeholders to implement novel integrated automated systems to streamline execution and analysis of cell therapy assays.

Cambridge, MA30+ days ago

$145,320–$176,100 Per Year

Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. This role offers the opportunity to drive scientific innovation and shape the strategic direction of novel immunotherapy development at BMS in a highly collaborative environment that is guided by strong science and an enduring drive to benefit patients with cancer.

Cambridge, MA30+ days ago

You will also pioneer the integration of state-of-the-art AI techniques into real-world biologics pipelines, working closely with wet-lab scientists, bioinformaticians, protein engineers, and drug discovery program teams . Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Cambridge, MA30+ days ago

$152,730–$185,100 Per Year

In this role, you will represent the Dev DMPK function on cross-functional development project teams; oversee developmental drug metabolism and disposition, and non-clinical pharmacokinetics activities of multiple projects; be responsible for preparation of regulatory dossier / submissions; and assist in developing strategy for the group. Within the Pharmaceutical Candidate Optimization (PCO) organization at BMS, the Development DMPK Team provides ADME (absorption, distribution, metabolism, and excretion), DDI (drug-drug interactions) and PK (pharmacokinetics) support for all pipeline assets throughout clinical development, from candidate nomination through registration and lifecycle management.

Cambridge, MA30+ days ago

$184,720–$223,800 Per Year

The role of Senior Principal Scientist within Discovery Biotherapeutics, Selection Technologies involves leading a high-performing team that is responsible for conducting selections using in vitro display platforms such as yeast and mRNA display to discover binders against targets of interest. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.

Cambridge, MA30+ days ago

$181,930–$220,500 Per Year

Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Cambridge Crossing, MA30+ days ago

$166,770–$202,086 Per Year

Hands on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN ), single cell (CITE-seq, scATAC-seq, perturb-seq) and spatial profiling (Visium, GeoMx, CosMX ). We seek a creative and passionate computational scientist to join the Neuroscience, Immunology, and Cardiovascular (NIC) discovery team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development.

Cambridge, MA30+ days ago

$160,060–$193,900 Per Year

Key responsibility of this role is to effectively collaborate with a cross functional team of asset scientists with deep disease, drug development and business knowledge to help drive an overall translational strategy, working closely with discovery and early development teams, late clinical development as well as with our team of laboratory scientists. + Leads small and large collaborations with academia and industry partners to identify biobanks, clinical trials and existing databases to collate multi-parameter genomic, immune and clinical datasets to mine for novel biomarkers of unmet need patients in conjunction with computational biologists, data scientists and statisticians.

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Principal Jobs in Winchester, MA

Jobs

Principal Mechanical EngineerMicro Tech

Principal Electronics & Software EngineerElectroswitch

Software Engineer, PrincipalDCS Corporation

Principal Mechanical EngineerSaab

Principal, Operations Research Analytics - HybridXPO

Principal Analog Mixed Signal ASIC Layout EngineerGCR Professional Services

Principal AI Field ArchitectBoomi

Principal Software Engineer (Networking) - PlatformElastic

Principal Radar Systems EngineerGCR Professional Services

Principal Manufacturing EngineerButler Aerospace and Defense

Principal Front-Office EngineerAxelon Services Corporation

IT Principal Front-Office EngineerAxelon Services Corporation

Nursing Director – Hematology/Oncology & Bone Marrow TransplantTufts Medical Center

Assistant Principal (2026-2027 School Year)Rutherford County Schools

1/2 STEM Teacher & 1/2 Assistant Principal at Midway Middle (26-27 School Year)Roane County Schools

Guild - Principal Clerk School Secretary Grade 23 (SY25-26)Boston Public Schools

Principal Cleaning Validation EngineerPfizer

Mergers & Acquisition, Lead Transaction PrincipalTeradyne

Principal Scientist (M.D. or D.O.)Exponent Inc.

Managing Principal, AI-Driven Commercial EffectivenessOdaia Intelligence Inc.

Principal Manufacturing Engineer, 4th ShiftApollo Professional Solutions

Principal Engineer - Stackpoint VenturesStackpoint Studio Inc

Principal Consultant - Aviation NoiseHARRIS MILLER MILLER & HANSON INC.

Principal Design Quality Engineer INova Biomedical

Principal Systems Engineer - POC DevicesNova Biomedical

Principal Research Associate/Associate Scientist, Molecular AssemblyTScan Therapeutics

Principal Electrical Engineer- Boston, MA- HybridMichael Page

Principal Electrical Engineer- Boston, MA- HybridMichael Page International

Pleasant Hill Elementary - PrincipalCumberland County School District

Principal Partner Platform AdvocateG-P

Principal Cybersecurity ArchitectTMS

Principal Solutions Architect Engineer, MicrogridAlphaStruxure EmployeeCo, LLC

Principal Security Researcher - AIVeracode

Principal DevOps EngineerVeracode

Principal, AnalyticsTrinity Partners, LLC

Principal Software EngineerAstrion

Principal Logistics ManagerAstrion

Principal Data Links and Communications EngineerAstrion

Principal Platform EngineerElucid

BAS Principal - Valuation, Financial Forensics, Litigation (VFL)LitmanGerson Associates

Principal Scientist, In Vivo Pharmacology, Oncology Discovery BiologyBristol Myers Squibb

Principal Scientist, QC Assay Automation, Cell Therapy in Devens, MABristol Myers Squibb

Principal Scientist, Cancer ImmunologyBristol Myers Squibb

Principal Scientist (AI/ML) - Predictive modeling, design and optimization for therapeutic antibodiesBristol Myers Squibb

Senior Principal Scientist, Development DMPKBristol Myers Squibb

Senior Principal Scientist, Discovery Biotherapeutics, Selection TechnologiesBristol Myers Squibb

Senior Principal Scientist- Immunology In Vivo PharmacologyBristol Myers Squibb

Principal Scientist Computational BiologyBristol Myers Squibb

Senior Principal Scientist/Associate Director, Translational Development, Lung Cancer Disease LeadBristol Myers Squibb

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