Principal Data Engineer (Service) Waters CorpPrincipal Data Engineer (Service)Milford, MAYou will bring deep technical expertise in service business data domains, operate with a high degree of independence, and contribute to the design and delivery of scalable data platforms that enable strategic decision-making for revenue growth, margin expansion, and operational excellence initiatives targeting $200M+ in EBIT improvement. Design and build scalable, reliable data platforms that integrate service delivery data (work orders, cases, products, geography), service team member data (roles, locations, workloads), service revenue and cost data, and proforma P&L information to enable strategic decision-making.
Sr. Principal Instrument Replacement Lead TA Instruments IncSr. Principal Instrument Replacement LeadMilford, MAPrincipal, Lifecycle Program Lead, you will be responsible for delivering transformative improvements in enterprise Instrument Replacement capabilities, defining and scaling a consistent, data driven approach to managing instrument lifecycle replacement across business units, regions, and commercial motions. Partnering with global sales leadership, commercial excellence, finance, IT, and operations, the desired business outcomes include translating lifecycle strategy into repeatable operating models that improve revenue retention, revenue growth and customer loyalty.
Analytical Science And Technology Principal Scientist Vertex Pharmaceuticals, IncAnalytical Science And Technology Principal ScientistBoston, MA$138,400–$207,600 / yearThe successful candidate will provide scientific leadership across microbiology method lifecycle management, external laboratory oversight, investigations, compliance, and continuous improvement to ensure robust, inspection-ready testing throughout the global network. This role serves as the microbiology technical leader and subject matter expert responsible for microbiological methods and microbial control strategies supporting late-stage development and commercial products.
Lab Lead – Principal Analyst Support RTXLab Lead – Principal Analyst SupportTewksbury, MassachusettsOur engineers are responsible for all elements of the development lifecycles for tests including test requirements, test system design, flight simulations, hardware-in-the-loop, computer-in-the-loop, advanced engineering prototyping technology, flight operations for manned and unmanned vehicles, environmental testing, environmental characterization, and engineering laboratory management. Ability to obtain INTERIM U.S. government issued security clearance is required prior to start date At RTX, the world largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems.
Associate Principal, Monitoring, Evaluation and Quality Improvement (MEQI) BME StrategiesAssociate Principal, Monitoring, Evaluation and Quality Improvement (MEQI)North Andover, MARemoteThis may include rural health evaluation design and implementation, multi-site evaluation architecture, performance measurement for complex public health initiatives, public health data strategy, health information exchange (HIE) integration, data governance, and capacity-building for public health agencies navigating a rapidly changing data landscape. What is consistent across strong candidates is a track record of leading complex engagements at the state level; managing and developing staff; holding client relationships with sophistication and commercial awareness; and contributing to business development with the credibility of someone who has delivered at scale.
Principal Machine Learning Engineer Cambridge Mobile TelematicsPrincipal Machine Learning EngineerCambridge, MA$177,000–$221,300 / yearExperience building large-scale data processing and orchestration: Spark or Beam, Airflow, Kafka or Pub/Sub, Docker, and Kubernetes on AWS, GCP, or Azure. Recognized innovator in mobility AI, earning top honors including the TIME Industry Leader in AI, a Gold Edison Award, and the Artificial Intelligence Excellence Award for AI for Social Good.
Process Engineer, Principal Scientist - Automation of Machinery and Processes Vertex Pharmaceuticals IncProcess Engineer, Principal Scientist - Automation of Machinery and ProcessesBoston, MA$141,800–$212,800 / yearTechnical Delivery: Lead major engineering workstreams and complex equipment development efforts from concept through implementation, including URS/FRS development, technology evaluations, RFP and vendor selection, facility & systems simulation, requirements mapping, safety risk assessments, FMEA execution, study design, FAT/SAT execution, technology transfer, and validation support. Cross-Functional Influence and Collaboration: Partner closely with Manufacturing, Process Development, Quality, Validation, Facilities, MSAT, Project Management, and external vendors/partners to ensure successful delivery of engineering and equipment initiatives across the product lifecycle.
NewPrincipal Clinical Data Manager Alnylam Pharmaceuticals IncPrincipal Clinical Data ManagerCambridge, MA$147,900–$200,100 / yearCollaborate with internal and external partners, including Biostatistics, Statistical Programming, Clinical Operations, Clinical Research, Quality Assurance, Global Patient Safety and Risk Management, and Regulatory Affairs; CROs, central and local laboratories, and other vendors. Collaborate with Statistical Programming to oversee SDTM validation efforts, performing review of validation reports, SDTM Reviewer Guides and define.xml files, and coordinating feedback to CRO while driving internal decision-making and overseeing issues to resolution.
NewPrincipal Scientist, DMPK Alnylam Pharmaceuticals IncPrincipal Scientist, DMPKCambridge, MA$147,200–$220,800 / yearThe candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance programs from discovery through clinical development. Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership teams to integrate PK, PD, efficacy, safety, and biomarker data and inform development decisions.
Principal Data Scientist Formation BioPrincipal Data ScientistBoston, MA$204,500–$267,000 / yearRecognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as TrialSpark Inc., has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in-licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients.
Remote Principal Statistical Programmer Global Channel ManagementRemote Principal Statistical ProgrammerCambridge, MassachusettsRemoteContribute and implement to statistical analysis plans; provide additional expertise in the analysis of clinical trial when it relates to protocol development, case report form design and data collection. Remote Principal Statistical Programmer requires: Minimum 10 years Pharmaceutical/Biotech programming experience including macro/tools development experience.
NewPrincipal Platform Software Engineer RTXPrincipal Platform Software EngineerWoburn, MassachusettsAbility to obtain INTERIM U.S. government issued security clearance is required prior to start date At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. Collaborate with cross-functional teams, including software developers, system engineers, and test teams, to ensure seamless integration of application software into system platforms.
Principal System Safety Engineer RTXPrincipal System Safety EngineerWoburn, MassachusettsActive and existing security clearance required after day 1 At RTX, the world largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. Raytheon’s System Safety / Human System Integration (HSI) Department ensures product safety by identifying hazards, assessing risks, and implementing solutions to protect people, hardware, and the environment.
NewProgram Cost Controls Principal Specialist *HYBRID* RTXProgram Cost Controls Principal Specialist *HYBRID*Tewksbury, MassachusettsThe selected candidate will be responsible for financial excellence across all program finance and business-related activities including cost and schedule execution and reporting, monthly EV execution & reporting, Latest Revised Estimates (LREs), Estimates at Complete (EACs), financial planning and analysis, proposal support, cash management, contract startup, execution, and closeout. The Global Patriot Sub Strategic Business Unit within the Land & Air Defense Systems (LADS) Strategic Business Unit of Raytheon is seeking a highly motivated and self-driven Finance professional to assume the role of Finance Principal Specialist for Domestic Patriot Production programs.
Sr Principal SW Development Engineer UKGSr Principal SW Development EngineerBoston, MA$163,900–$235,550 / yearOperating at a principal level, this role goes well beyond traditional requirements gathering—serving as a trusted advisor, systems strategist, and transformation leader across large, multi-phase programs involving D365 Finance & Operations, and integrated enterprise platforms. This role partners closely with Finance and Go To Market teams and IT leadership to translate complex business objectives into scalable, compliant, and future-ready system solutions.
Principal Merger & Acquisition Integration UKGPrincipal Merger & Acquisition IntegrationLowell, MA$163,900–$235,550 / yearView the E-Verify posters here (https://www.e-verify.gov/sites/default/files/everify/posters/EVerifyParticipationPoster.pdf) . With the world's largest collection of workforce insights, and people-first AI, our ability to reveal unseen ways to build trust, amplify productivity, and empower talent, is unmatched.
Principal, Employee Relations, ER Strategy Amazon.com IncPrincipal, Employee Relations, ER StrategyBoston, MAThe successful candidate will have a demonstrated ability to i) assess data, workplaces, behaviors, external trends, and relationships to identify risks and gaps in the work environment; ii) develop and execute sustainable, scalable initiatives, mechanisms, and programs that affect long-lasting changes at all levels; iii) influence leaders to win alignment, support, and change agents; and iv) work cross-functionally to design and execute effective large-proactive strategies. Guided by Think Big and Customer Obsession, with employees as our customers, the team partners cross-functionally with Operations leadership, Legal, Corporate Communications, Learning & Development, and HR Business Partners to deliver scalable solutions that build trust and enhance the employee experience.
Oliver Wyman Actuarial - P&C -Principal Marsh & McLennan Companies IncOliver Wyman Actuarial - P&C -PrincipalBoston, MA$180,000–$250,000 / yearThe Actuarial Practice of Oliver Wyman seeks to invest in its people by fostering a safe and inclusive environment, respecting and welcoming different perspectives, promoting an ownership culture, providing opportunities for individuals to develop their personal brand, and celebrating successes and rewarding performance. In addition to delivering traditional actuarial services such as reserving, pricing, and capital modeling, this leader will help modernize delivery approaches by leveraging analytics, automation, and emerging AI technologies to create more scalable, data-driven client solutions.
Principal Electrical Engineer - Test Equipment Maintenance Support RTXPrincipal Electrical Engineer - Test Equipment Maintenance SupportMassachusettsActive and existing security clearance required after day 1 At RTX, the world's largest aerospace and defense company, 185,000 great minds are united by purpose and inspired to make a difference solving the world’s most complex problems. Raytheon is seeking a motivated 1st shift Principal Electrical Engineer to fill key Maintenance, Repair and Engineering support role within the Metrology & Test Equipment Maintenance (MTEM) Department, located in Andover MA.
Principal Security Architect, Cloud & Infrastructure Cambridge Mobile TelematicsPrincipal Security Architect, Cloud & InfrastructureCambridge, MAResponsibilities: Own the end-to-end security architecture for CMT''s products, including mobile SDKs, backend services, APIs, data pipelines, and partner integrations. You''ll stay hands-on with architecture while shaping security strategy across the organization through technical leadership, collaboration, and sound engineering judgment rather than people management.