The CRNII facilitates compliances with the research protocol and Good Clinical Practice guidelines; uses multiple communication styles and methods to facilitate the effective coordination of clinical trials across disciplines and clinics, acting as a liaison between the principle investigator, sponsoring agent, study patients, referring physicians, pharmacist, statisticians and other members of the research team; takes leadership in ensuring an effective informed-consent process and study subject safety for the duration of the trial; ensures compliance with protocol procedures, assessments and reporting requirements; assists physicians in ensuring adequate source documentation and data-collection that validate the integrity of the clinical trial; assist in enhancing recruitment of study participants, helping with the design and implementation of recruitment strategies for identifying and assessing patients who may be eligible for a clinical trial; and the CRN demonstrates leadership in adhering to ethical principles in the conduct of clinical trials in order to protect study subjects and data integrity. Clinical Research at the Brown Cancer Center includes early phase, novel treatment, multi-centered, cooperative and intergroup trials, multi-institutional pharmaceutical trials, and single- or multi-centered investigator-initiated trials.