Principal Solutions Architect (Databricks) Blue Orange Digital LLCPrincipal Solutions Architect (Databricks)Philadelphia, PAYou can whiteboard a multi-workspace Unity Catalog governance model, explain when Photon earns its cost, diagnose a skewed join from a Spark UI screenshot, and reason about Delta Lake file layout and liquid clustering under real workloads. Hands-on command of Spark, Delta Lake, Unity Catalog, Databricks Workflows, Delta Live Tables, MLflow, and Mosaic AI, plus fluency in at least one major cloud (AWS, Azure, or GCP) and infrastructure as code.
Principal Research Scientist - Product Development (M/F/D) Elanco Animal Health IncorporatedPrincipal Research Scientist - Product Development (M/F/D)Monheim, DEIn this role, you will provide scientific and technical leadership for Oral Solid Dosage (OSD) products and other dosage forms as needed, solve complex formulation challenges, and guide internal teams and external partners from early development through commercial scale-up. Your Responsibilities: Lead the design, development, and optimization of Oral Solid Dosage (OSD) formulations, including tablets and medicated chewables, from enabling formulations and prototype development through final product design and process scale-up and transfer to manufacturing sites.
Principal Project Manager Pipe RecruitPrincipal Project ManagerFort Washington, PennsylvaniaThis role is responsible for ensuring the successful direction, coordination, implementation, execution, control, and completion of large-scale projects and programs. Collaborate with stakeholders to define resource needs and assemble cross-functional teams, including external vendors when necessary.
Principal Cloud Platform Engineer Temple University Health SystemPrincipal Cloud Platform EngineerPhiladelphia, PAThe principal engineer operates at the highest level of technical complexity, solving the most challenging problems and making architecture decisions with organization-wide impact. The Principal Cloud Platform Engineer serves as the organization's foremost technical authority on cloud platforms, providing strategic direction and thought leadership.
Principal Engineer The High CompaniesPrincipal EngineerPhiladelphia, PAESSENTIAL JOB FUNCTIONS: Engineering leadership and management: Ensure that on projects assigned within the region or national account, technical staff: Adhere to StructureCare quality, schedule, and budget requirements, adjusting as necessary to meet targets. Manage assigned direct and/or indirect report relationships including: Conduct all required performance reviews with regular check-ins, documentation and positive coaching as required to ensure the development of engineers assigned.
Tech Lead/ Principal Software Engineer Towne Park Ltd.Tech Lead/ Principal Software EngineerPlymouth Meeting, PA$182,000–$200,000 / yearWorking closely with Architecture, Product Management, and Quality Engineering, the Tech Lead drives engineering excellence, supports business priorities, and promotes best practices in modern software development, cloud technologies, and AI-assisted engineering. Work Experience: 8+ years of experience developing enterprise software, including 2+ years leading engineering teams as a Technical Lead, Principal Engineer, or similar technical leadership role.
Sr. Lead (Principal) QA Analyst PJM Interconnection LLCSr. Lead (Principal) QA AnalystPACoordinate testing efforts across different lines of business involved in implementing various aspects of FERC orders as new orders are issued. Essential Functions: Develop and implement testing practices and strategies across the enterprise, with a focus on FERC order compliance-related implementations.
Principal Engineer, DevOps & Infrastructure ZeroEyes IncPrincipal Engineer, DevOps & InfrastructureConshohocken, PADrive FedRAMP/NIST alignment: Map controls (NIST 800-53), lead technical portions of the SSP, implement CIS/STIG hardening, FIPS-validated crypto usage, logging/monitoring requirements, and support ATO and continuous monitoring (ConMon) with auditors/3PAO. ZeroEyes was founded by former Navy SEALs, self-starters and elite technologists with a mission to reduce the threat and impact of mass shootings and gun-related violence using our best-in-class artificial intelligence (AI) platform that detects visible firearms before theres a threat.
Associate Principal Scientist, Regulated Bioanalytics (Pharmacokinetics) Merck & Co IncAssociate Principal Scientist, Regulated Bioanalytics (Pharmacokinetics)West Point, PA$142,400–$224,100 / yearDemonstrate advanced expertise in regulated bioanalytical methods for quantifying therapeutic and biotherapeutic drug candidates and anti‑drug antibodies, using ligand‑binding assay-based platforms (e.g., Meso Scale Discovery, Gyrolab, Ella), LC‑MS methodologies, and emerging bioanalytical technologies. Required Skills: Analytical Chemistry, Assay Development, Bioanalysis, Bioanalytical Techniques, Clinical Data Interpretation, Immunogenicity, IND Submission, Leadership, Liquid Chromatography-Mass Spectrometry (LC-MS), Pharmacokinetics, Project Management, Regulatory Compliance, Regulatory Documents.
Principal Scientist (Director), Translational Medicine - Infectious Diseases Merck & Co IncPrincipal Scientist (Director), Translational Medicine - Infectious DiseasesWest Point, PA$260,300–$409,700 / yearPrimary responsibilities for the Principal Scientist include the following: Working with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets, including the design of preclinical and clinical experiments to validate targets and/or pathways, and leveraging this work for development of novel therapeutics. Translational Medicine is specifically responsible for: Contributing to the identification of novel targets by partnering with Discovery Sciences to bring a clinical perspective into the earliest stages of target identification and validation, and to execute clinical studies to evaluate the relevance of potential targets to human disease in order to justify full development.
Principal Technical Program Manager - Operating Model Enablement JPMorgan Chase & CoPrincipal Technical Program Manager - Operating Model EnablementWilmington, DEAs a Principal Technical Program Manager in the Corporate Sector''s Operating Model Enablement team, you will lead complex, multi-functional technology projects and programs that will impact experiences for multiple groups across the firm, including clients, employees, and stakeholders. Develop and implement strategic technical program plans, aligning with organizational goals and cross-functional collaboration, and oversee complex program execution by managing resources, budgets, and timelines while mitigating risks and addressing roadblocks.
Principal Technical Program Manager - AI Product Development Lifecycle JPMorgan Chase & CoPrincipal Technical Program Manager - AI Product Development LifecycleWilmington, DEAs a Principal Technical Program Manager in Operating Model Enablement, you will lead complex, multi-functional technology projects and programs that will impact experiences for multiple groups across the firm, including clients, employees, and stakeholders. Develop and implement strategic technical program plans, aligning with organizational goals and cross-functional collaboration, and oversee complex program execution by managing resources, budgets, and timelines while mitigating risks and addressing roadblocks.
Associate Principal Scientist, Downstream Bioprocess Modeling, Digital Insights Merck & Co IncAssociate Principal Scientist, Downstream Bioprocess Modeling, Digital InsightsWest Point, PA$142,400–$224,100 / yearRequired Skills: Analytical Testing, Analytical Testing, Biochemistry, Cell Line Development, Chemical Engineering, Computer Simulations, Data Modeling Techniques, Detail-Oriented, Downstream Process Development, Downstream Processing, Drug Delivery Technology, Drug Development, Expression Vectors, Interpersonal Relationships, Kinetics, Laboratory Instrumentation, Leading Project Teams, Method Development, Model Development, Model Driven Design, Molecular Biology, Parameter Estimation, Perform Testing, Pharmaceutical Formulations, Pharmaceutical Process Development {+ 9 more}. The successful candidate will play a technical leadership role in embedding mechanistic downstream modeling into DSCS decision-making-partnering closely with DSP scientists, process engineers, and DS technical leads to translate model outputs into actionable purification and manufacturing decisions.
Principal Medical Writer CSL Behring LLCPrincipal Medical WriterKing of Prussia, PAHe or she is also responsible for the messaging strategy across a program of work, for the provision of strategic input into the development of clinical development plans and submission plans, and for analyzing proposed plans, programs, individual studies and related documents for their ability to deliver the information required by the target audience (ie, regulatory authority) in a compelling fashion with accuracy and consistency. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.
Senior Insights and Analytics Principal, Large Pharma IQVIASenior Insights and Analytics Principal, Large PharmaWayne, PennsylvaniaThe Senior Insights and Analytics Principal is a senior analytics leader responsible for driving business growth, shaping analytic solutions, and delivering strategic insights that create measurable impact for our largest and most complex biopharma clients. Leveraging deep industry knowledge and strong client relationships, this role combines commercial acumen, data-driven problem solving, and thought leadership to help clients address complex brand and market challenges.
NewPrincipal Scientist (Director), Translational Medicine - Cardiovascular Merck & Co IncPrincipal Scientist (Director), Translational Medicine - CardiovascularWest Point, PA$260,300–$409,700 / yearInterface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late-stage Clinical Research throughout research sites around the world. Contributing to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into the earliest stages of target identification and validation, and executing clinical studies to evaluate the relevance of potential targets to human disease in order to justify investment in clinical development programs.
Insights and Analytics Principal, Large Pharma IQVIAInsights and Analytics Principal, Large PharmaWayne, PennsylvaniaLeveraging deep industry knowledge and strong client relationships, this role combines commercial acumen, data-driven problem solving, and thought leadership to help clients address complex brand and market challenges. The Insights and Analytics Principal is a senior analytics leader responsible for driving business growth, shaping analytic solutions, and delivering strategic insights that create measurable impact for our biopharma clients.
Associate Principal Scientist/Engineer, Medical Device and Combination Products, ISO/DV Testing Manager Merck & Co IncAssociate Principal Scientist/Engineer, Medical Device and Combination Products, ISO/DV Testing ManagerWest Point, PA$142,400–$224,100 / yearResponsibilities will include: (1) strategic and tactical (day-to-day) management of design verification testing to support our commercial products to meet critical project timelines, (2) technical oversight of method development, validation, and implementation of analytical methods and associated investigational support at both internal and external laboratories, (3) ensuring safety, environmental and cGMP and ISO 13485 compliance for all laboratory activities and operations, (4) collaborating with CPDA program leads to drive test method development, validation and implementation of new instrumentation/analytical technologies for the laboratory to support current and future commercial MDCP DV testing, and, (5) oversight and technical coaching of CPDA analysts in the ISO laboratory. The Center for Packaging & Device Analytics (CPDA), within our Manufacturing Division, has responsibility for applied physical, material & analytical science to support production and commercialization of product packaging and drug-delivery medical device/combination-products (MDCPs), such as auto-injectors and pre-filled syringes.
Senior Principal Scientist, Clinical Research, Thoracic Malignancies Merck & Co IncSenior Principal Scientist, Clinical Research, Thoracic MalignanciesNorth Wales, PA$282,200–$444,200 / yearMonitoring and managing the conduct of ongoing or new clinical trials for investigational or marketed Oncology drugs; Analyzing and summarizing the clinical findings from studies to support decisions regarding safety and efficacy as well as new drug applications, clinical study reports, or publication; and. Assist the Senior/Executive Director in ensuring that appropriate corporate personnel are informed of the progress of studies of our Company's and competitors' drugs and internal and external expert opinion on scientific questions relevant to his/her areas of responsibility.
NewPrincipal Scientist, Translational Clinical Biomarkers Merck & Co IncPrincipal Scientist, Translational Clinical Biomarkersupper gwynedd, PA$190,800–$300,300 / yearFor cardiovascular and metabolic programs, develop biomarker strategies addressing areas such as target engagement, pathway modulation, disease biology, pharmacodynamic response, patient heterogeneity, and relationships between biological effects and clinical outcomes. The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity, dose and regimen selection, clinical endpoints, and opportunities for precision medicine.