Working closely with the Program Manager, Technical Lead, Software Engineering Lead, Government stakeholders, and technical Subject Matter Experts (SMEs), the Systems Engineering Lead will ensure that enterprise systems are architected, integrated, and operated to support NCI's biomedical research, clinical research, and administrative missions. The successful candidate will lead cross-functional engineering efforts spanning cloud infrastructure, systems integration, identity management, networking, storage, automation, and platform modernization while ensuring high availability, security, and operational excellence.