Senior Scientist In vivo Pharmacology & Translational Sciences, Cambridge, MA Isomorphic Labs LimitedSenior Scientist In vivo Pharmacology & Translational Sciences, Cambridge, MACambridge, MAProven track record managing multi-vendor CRO networks (including contract negotiation, timeline accountability, and data quality oversight) and the ability to lead and influence teams without direct authority, setting technical direction and driving execution across matrixed, externally-dependent programs. Act as a vital bridge between computational prediction and experimental reality, collaborating closely with: ML and Data Science Teams: To translate in silico predictions into physical validation protocols and provide clean data loops to train future models, iteratively improving the predictive accuracy of our proprietary drug design platform.
AI/ML Research Engineer Manifold Bio IncAI/ML Research EngineerBoston, MAYou will be expected to take ownership of engineering challenges in our ML pipeline, from data processing and model training to deployment and monitoring, while collaborating closely with our research team to translate cutting-edge ideas into robust, scalable systems. Our in vivo-centric discovery platform produces millions of experimentally validated protein designs per campaign, creating the datasets that make our models possible and our approach uniquely powerful.
AIRx Director, Computational & AI Biologics Design Lead 3316 Takeda Development Center AmericasAIRx Director, Computational & AI Biologics Design LeadBoston, MassachusettsThis role drives in silico biologics design, applies generative AI and structure-informed methods to antibody and large-molecule programs, and connects Takeda’s internal AI/ML platform capabilities to the day-to-day decisions of a fast-moving drug-hunting team. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
Ai/Ml Research Engineer Manifold BioAi/Ml Research EngineerBoston, MA$140,000–$225,000 / yearManifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. You will be expected to take ownership of engineering challenges in our ML pipeline, from data processing and model training to deployment and monitoring, while collaborating closely with our research team to translate cutting-edge ideas into robust, scalable systems.
Research Associate II Integrated Resources, IncResearch Associate IILexington, MassachusettsContractorLocation: Lexington, MADuration: 6+ MonthsOur client is looking to hire Research Associate II Biologist to perform laboratory duties primarily related to the development and implementation of in vitro biochemical and cellular assays required to profile small molecules and biologics of interest. Candidate should have hands on experience and proficiency with the use of analytical tools, biochemical and cell-based assays such as ELISA, Western blot, spectrophotometry, fluorimetry, molecular biology, transfections, PCT and RT-PCR, protein labeling and modification.
Computational Biology & Bioinformatics Lead Institute for Protein InnovationComputational Biology & Bioinformatics LeadBoston, MassachusettsThe Institute's deep protein expertise, collaborative spirit and research tools are powering new biomedical and therapeutic discoveries with a growing community of researchers at Harvard Medical School, Boston Children's Hospital and other institutions across Greater Boston and beyond. Founded in 2017 and located in Boston’s Longwood Medical Area, the Institute’s three-pronged strategy is to build protein tools, conduct related internal research and develop educational programs for the protein science and biological research communities.
Postdoctoral Research Fellow Brigham and Women's HospitalPostdoctoral Research FellowBoston, MA$70,000–$71,750 / yearResearch may include the design and organic synthesis of radiation-responsive linkers and prodrugs; development of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using HPLC, LC-MS, NMR spectroscopy, and related analytical methods. The fellow will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.
Bioinformatics Scientist - III (Senior) Johnson Service GroupBioinformatics Scientist - III (Senior)Cambridge, MARequired Experience and Skills:PhD (or equivalent) in statistical genetics, genetic epidemiology, population genetics, computational biology, bioinformatics, biostatistics, epidemiology, or a related quantitative discipline, with a minimum of 5 year of postdoctoral or equivalent research experience in complex disease genetics. The CDG group leverages large-scale data resources, such as FinnGen, the Alliance for Genomic Discovery, Our Future Health, UK Biobank Pharma Proteomics Project, Open Targets, and other public and proprietary datasets, to advance Mercks drug development pipeline through human genetics.
NewScientist/Senior Scientist, Immunology RavenScientist/Senior Scientist, ImmunologyCambridge, Massachusetts$120,000–$165,000 / yearExperience designing and analyzing in vivo PK/PD and efficacy models, including ex vivo analyses of cells from blood/tissue by flow cytometry and of soluble proteins in serum/tissues by ELISA/MSD. RA Capital's knowledge engine is guided by our TechAtlas internal research division, and Raven, RA Capital’s company building team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined.
Scientist I / Scientist II, Computational Protein Design Generate BiomedicinesScientist I / Scientist II, Computational Protein DesignSomerville, MassachusettsThe ideal candidate combines deep structural intuition with a demonstrated ability to rapidly assess and apply protein design methods and metrics across diverse design problems, thinks in terms of reusable capabilities, benchmarks, and feedback loops across applications, and uses modern generative models and experimental readouts to guide iterative design cycles across modalities. This role sits at the intersection of machine learning, structural biology, and therapeutic development, where you will stay at the leading edge of internal and external models for de novo protein design and systematically benchmark, integrate, and apply them within tightly integrated design–build–test–learn cycles to advance our therapeutic pipeline and impact patients' lives.
Postdoctoral Fellow - Computational Immunology & Translational Oncology Harvard UniversityPostdoctoral Fellow - Computational Immunology & Translational OncologyBoston, MA$72,000–$77,500 / yearExperience applying machine learning and statistical modeling to biological or clinical datasets, including unsupervised clustering, dimensionality reduction, survival modeling, feature selection, and supervised learning approaches such as random forests, gradient boosting, or Cox regression. Prior research or work experience with cancer immunology, tumor microenvironment analysis, immune cell-state annotation, pathway enrichment, and biomarker discovery, especially in the context of immunotherapy response or tertiary lymphoid structures.
Oncology Translational Medicine Lead Director AstraZeneca PlcOncology Translational Medicine Lead DirectorWaltham, MA$183,768.80–$275,653.20 / yearAs Oncology Translational Medicine Lead Director, you will set the biomarker vision for an innovation-rich ADC portfolio and convert it into clinical impact-informing indication selection, dose and schedule, rational combinations, and patient selection that change outcomes. Accountabilities: Translational Strategy Ownership: Define and deliver end-to-end biomarker strategies for ADC assets from Phase 1 to Phase 3, aligning assays and analyses to decision points to de-risk development and enable swift progression.
Ai/Ml Scientist, Protein Foundation Models Manifold BioAi/Ml Scientist, Protein Foundation ModelsBoston, MA$140,000–$225,000 / yearManifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match.
Scientist I / Scientist II, Computational Protein Generation Generate Biomedicines IncScientist I / Scientist II, Computational Protein GenerationSomerville, MA$140,000–$200,000 / yearThe ideal candidate combines deep structural intuition with a demonstrated ability to rapidly assess and apply protein design methods and metrics across diverse design problems, thinks in terms of reusable capabilities, benchmarks, and feedback loops across applications, and uses modern generative models and experimental readouts to guide iterative design cycles across modalities. This role sits at the intersection of machine learning, structural biology, and therapeutic development, where you will stay at the leading edge of internal and external models for de novo protein design and systematically benchmark, integrate, and apply them within tightly integrated design-build-test-learn cycles to advance our therapeutic pipeline and impact patients' lives.
NewScientist Sr. Scientist, Cardiovascular and Metabolic Disease Flagship Pioneering IncScientist Sr. Scientist, Cardiovascular and Metabolic DiseaseCambridge, MA$100,000–$181,500 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Lab Operations Specialist AbiologicsLab Operations SpecialistWatertown, Massachusetts$72,000–$103,000 / yearFlagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Assistant Professor of Biological Sciences Wellesley CollegeAssistant Professor of Biological SciencesWellesley, MACampus Privileges: Enjoy free use of our state-of-the-art athletic and fitness facilities with onsite fitness classes, Library resources, and seize opportunities to attend diverse campus events that contribute to a vibrant community. Work/Life and Wellness: Caregiving support through Wellthy, legal plan insurance, pet insurance discount and a variety of other resources including retirement planning, and access to cultural and leisure activities throughout metro-Boston.
Research Technician Brigham and Women's HospitalResearch TechnicianBoston, MA$21–$29.01 / hourResearch may include the testing and purification of radiation-responsive linkers and prodrugs; development and synthesis of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using cell culture assays, mouse tumor models, and microscopy. The technician will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.
Senior Director - Biointelligence Amgen Inc.Senior Director - BiointelligenceCambridge, MAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. This role requires a leader with deep expertise in machine learning for biological systems, experience building and mentoring high-performing scientific teams, and a track record of translating advanced computational methods into impactful research capabilities.
Scientist, Bioconjugation Manifold Bio IncScientist, BioconjugationBoston, MA$118,000–$138,000 / yearYou will join a team with deep experience in protein chemistry, RNA biology, and biology, and work closely with a highly interdisciplinary team of creative experimental and computational scientists to advance our tissue-targeted oligomedicines pipeline. Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.