Title will be commensurate with level of qualifications and experience Demonstrated scientific leadership of in vitro and in vivo pharmacology projects in discovery and/or preclinical research and development, including study designs and interpretation that informed project decisions Exceptional scientific aptitude: sharp critical thinking, sound experimental judgment, and the agility to learn new biology quickly across disease areas Strong hands-on skills in tissue processing and analysis (RNA and protein extraction, RT-qPCR, immunoassays, histology/IHC/ISH), mammalian cell culture in cell lines and primary cell models, and cell-based assays, with a record of establishing new methods Track record managing CRO-executed in vivo studies: vendor qualification, protocol alignment, budget and timeline management, and critical evaluation of external data; non-human primate study experience is a plus Hands-on rodent experience (dosing, in-life assessment, terminal collection) sufficient to design realistic protocols and challenge a CRO Sound professional judgment: works independently, prioritizes across concurrent studies, and knows when to escalate Strong quantitative and statistical fluency, including study powering and appropriate analysis of in vivo data Clear scientific writing and communication: protocols, study reports, and data presentations to project teams and leadership Highly organized and detail-oriented, with a record of consistently delivering robust, decision-quality in vitro and in vivo data Experience with oligonucleotide or other nucleic acid therapeutics (tissue exposure, target modulation, PK/PD) and exposure to IND-enabling studies are a plus. Compile, QC, and interpret in vitro and in vivo data; author study reports; share results with cross-functional teams; and contribute to publications, patents, and presentations Preferred Qualifications -Experience with oligonucleotide therapeutics (e.g., ASOs, siRNA) is a plus.