Coordinate specialist reviews of relief and vent systems, emergency depressurization, containment and drainage, ventilation, gas detection, fire protection, hazardous-area electrical classification, grounding and bonding, safety instrumented functions, interlocks, alarms, permissives, and emergency shutdown systems as applicable. Ensure hazards associated with reactive chemistry, exothermic reactions, incompatible materials, loss of agitation or cooling, overpressure, vacuum, thermal decomposition, charging errors, contamination, flammable or toxic releases, static electricity, and human factors are addressed in the design and operating strategy.