The Senior Director, State Government Affairs & Patient Advocacy reports to the Head of State Government Affairs & Patient Advocacy, and leads an integrated, multi-regional field organization of state government affairs and patient advocacy regional directors across East territory, serving as the East leader accountable for aligned state government affairs and grassroots patient advocacy strategy, execution, and performance. This role represents Vertex externally with policymakers, regulators, patient advocacy organizations, community leaders, provider organizations, professional societies, and other key stakeholders, and serves as a leader in US Public Affairs to integrate those engagements with internal teams to advance business objectives, protect patient access, and support disease education, screening, and reimbursement priorities.