Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development 3316 Takeda Development Center AmericasSenior/Principal Scientist, Analytical Cell Line Engineering and Bioassay DevelopmentLexington, Massachusetts$154,400–$242,550 / yearHow you will contribute: Lead the design, generation, characterization, and lifecycle management of stable mammalian analytical cell lines expressing targets of interest, receptor systems, or reporter constructs to support potency and functional bioassays. Operating at the interface between Discovery, Global Biologics, Analytical Development, and late-stage potency teams, this role translates product mechanism of action into scientifically sound, phase-appropriate cell line and assay strategies.
Principal, Fund Controller Partner's CapitalPrincipal, Fund ControllerBoston, MassachusettsClients include Syracuse University, Sesame Workshop, INSEAD Business School, New York’s Metropolitan Opera, San Francisco Symphony, Eton College, Colorado College, several Oxford and Cambridge University Colleges, several family offices around the world, and senior executives from leading global investment firms. With $75B+ in assets under management, the firm constructs customized investment portfolios for its clients tapping into its deep network of partnerships with what we consider exceptional asset managers across all major asset classes.
Principal Mechanical Design Engineer Boston Human Capital PartnersPrincipal Mechanical Design EngineerSomerville, MassachusettsFounded in 2011 by graduates of MIT and RISD (Rhode Island School of Design), and backed by Engine Ventures, Techstars, Fortistar and Gates Corporation, RISE Robotics is leading the way to Zero Emission heavy machinery by providing the world’s most efficient and productive alternative to hydraulics. Proven technical aptitude and experience with electro-mechanical design and related manufacturing processes that might include: complex mechanical assemblies; rotating machinery; tolerance studies; design for assembly / manufacturing; EE and ME component and material selection; FMEA; design for life.
Process Development Principal Scientist Amgen Inc.Process Development Principal ScientistCambridge, MAIn addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. In this vital role as an Attribute Sciences team lead and group lead you will work to provide strategic analytical leadership to teams developing commercial manufacturing processes for synthetic and hybrid molecules and collaborate closely with Drug Substance, Drug Product and Product Quality colleague.
Principal Mechanical Design Engineer RISE RoboticsPrincipal Mechanical Design EngineerSomerville, MA$175,000–$200,000Founded in 2011 by graduates of MIT and RISD (Rhode Island School of Design), and backed by Engine Ventures, Techstars, Fortistar and Gates Corporation, RISE Robotics is leading the way to Zero Emission heavy machinery by providing the world’s most efficient and productive alternative to hydraulics. Proven technical aptitude and experience with electro-mechanical design and related manufacturing processes that might include: complex mechanical assemblies; rotating machinery; tolerance studies; design for assembly / manufacturing; EE and ME component and material selection; FMEA; design for life.
NewPrincipal Design Quality Engineer Fresenius Medical CarePrincipal Design Quality EngineerLawrence, MassachusettsDeep understanding and experience with Design Control techniques including Design Planning, Design Inputs, Design Outputs, Design Reviews, Design Verification, Design Validation, Design Changes, Design Transfer, and Design History Files (Design and Development Files). Investigates root cause solutions for product release through nonconformance reports (NCR), corrective and preventative actions (CAPA), and material containment and hold forms (MCH) and affected lot hold forms (ALH).
NewPrincipal System Architect TE Connectivity plcPrincipal System ArchitectMarlborough, MARemote$177,800–$266,600 / yearDrive thought leadership by educating and influencing internal and external stakeholders, from executives and product teams to key decision-makers in customer organizations, on emerging industry trends, TE's technical capabilities, and high-value engineering solutions. Serve as the primary technical liaison for TE's customers, actively engaging with hyperscalers, OEMs, and system architects to gain deep insights into next-generation compute, AI, storage, and networking challenges.
NewAssociate Principal Scientist, In Vivo Pharmacology, Oncology Merck & Co IncAssociate Principal Scientist, In Vivo Pharmacology, OncologyBoston, MA$144,800–$227,900 / yearRequired Skills: Immunoassays, Immunohistochemistry (IHC), Immunology, In Vivo Models, In Vivo Studies, Mass Spectrometry Imaging, Molecular Biology, Mouse Models, Multiplex Assays, Oncology, Pharmacodynamics, Pharmacokinetics, Pharmacology, Preclinical Research, Tumor Biology. EDUCATION: PhD in Oncology, Pharmacology, Biology, Pharmaceutical Sciences, Chemistry, Immunology, Biotechnology, Molecular and Cell Biology, or related STEM field with 5+ years of industry / biotech experience in Oncology drug discovery, or an MS with 7+ years of experience, or a BS with 10+ years of experience.
Principal C# Engineer / Technical Lead Integrated Computer SolutionsPrincipal C# Engineer / Technical LeadWaltham, MassachusettsICS blends the art of visual design and agile engineering to help our clients develop their products into devices that delight in a wide range of technologies. As a Principal Engineer / Technical Lead, you will be responsible for the design, development, and testing of software products in the Microsoft stack in the MedTech and industrial space.
Principal Noise Consultant AcentechPrincipal Noise ConsultantCambridge, MAFull timeAcentech, a multidisciplinary design consulting firm specializing in acoustics, vibration, audiovisual systems, IT and security system design seeks to hire a senior- to principal-level consultant to work with our Noise and Vibration team. We foster a collaborative environment of diverse talent, and encourage people of color, lesbian, gay, bisexual, transgender, queer and non-binary people, neurodivergent, veterans, parents, and individuals with disabilities to apply.
Principal Thermal Mechanical Engineer FlexPrincipal Thermal Mechanical EngineerLittleton, MassachusettsThe Principal Mechanical Engineer will provide technical leadership, mentorship, and hands-on expertise in mechanical design, fluid dynamics, and heat transfer but also work closely with customers in communicating the art of the possible with JetCool technology and building a strong customer relationship on a technical level. Lead the initial design, analysis, and optimization of complex fluid systems from concept initial CAD to final detailed CAD and drawing for liquid cooling, including cold plates, pumps, fluids, tubing, and heat exchangers, for the latest computer processing chipsets.
Principal RA Associate Devices Fresenius Medical CarePrincipal RA Associate DevicesWaltham, MassachusettsResponsible for preparing FDA submissions necessary for new product approvals/clearances which include Premarket norifictoins-510(k)s, Premarket Approval Applications (PMAs) and supplements, Investigational Device Exemptions (IDEs) submissions. Serves as the primary regulatory resource for change to and prioritization of projects, resource assignment and efficient management of the development and change processes.
Principal SAP S/4HANA Architect & Lead WayfairPrincipal SAP S/4HANA Architect & LeadBoston, MA$160,225–$176,719 / yearThe SAP Engineering team is responsible for maintaining a highly complex SAP installation used in the Finance department for all General Ledger, Accounts Payable, and Accounts Receivable functions. Experience with high-volume integrations, understanding how SAP interacts with non-SAP systems (Java/Python microservices, cloud-native platforms).
Principal Software Engineer Boston Human Capital PartnersPrincipal Software EngineerBoston, MassachusettsRemoteThis role centers on building high-performance distributed systems, powering data-intensive services, and enabling seamless, secure integrations across modern IT and security ecosystems. only) and best suited for engineers who excel in fast-moving startup environments where autonomy, rapid iteration, and strong technical judgment are essential.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Principal Program Scheduler Torch TechnologiesPrincipal Program SchedulerHanscom AFB, MassachusettsBy enabling aircrews to electronically receive and process tasking orders, intelligence inputs, target coordinates, and mission‑critical flight and weapons data, MPS enhances combat effectiveness, increases sortie generation rates, and improves aircrew readiness and survivability across the Combat Air Forces (CAF) and Mobility Air Forces (MAF). Several factors can influence the salary for a position including but not limited to, Federal Government contract labor categories and contract wage rates, geographic location, business considerations, scope and responsibilities of the position, local or other applicable market conditions, and internal equity.
NewPrincipal FPGA Engineer Ayo SemiconductorPrincipal FPGA EngineerBoston, MassachusettsOur photonic processors will provide orders of magnitude improvement in speed and power efficiency in comparison to conventional digital compute platforms by taking advantage of the natural parallelism, speed and energy efficiency of light. Support the hardware team by performing FPGA trade studies and assessing the viability of proposed pin mappings on developmental circuit card assemblies.
Principal Engineer, Data Infrastructure KlaviyoPrincipal Engineer, Data InfrastructureBoston, MA$244,000–$366,000 / yearIn addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑augmented data operations: Semantic discovery and auto‑documentation cover the majority of high‑value datasets; AI‑assisted DQ monitors reduce data incidents on top pipelines by 25-40%; pipeline authoring and review times drop 15-25% with AI in the loop.
Principal Engineer, Core Infrastructure KlaviyoPrincipal Engineer, Core InfrastructureBoston, MA$248,000–$372,000 / yearIn addition to base salary, our total compensation package may include participation in the company’s annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility. AI‑enabled platform: Approved AI tooling is integrated into IDE/CI/CD with repo policies and auditability; 70% MAU among eligible engineers; MTTR down 20–30% via AI‑assisted triage; flaky‑test rate decreases through targeted, AI‑suggested fixes.
Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).