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Director Clinical Operations

Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. COMPANYMammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics.

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<br/><b>Mammoth BioSciences</b><br/><br/><div><b>OPPORTUNITY</b></div><div>Mammoth Biosciences is seeking an experienced Director, Clinical Operations to join our team. This role will ensure that clinical stage programs achieve program objectives within established timelines, budget, and quality standards. The selected candidate will be involved in contributing to the development of clinical program strategy, building a clinical operations team, and ensuring superior execution and transparency within the department. They will have primary responsibility for clinical trial program oversight within assigned indications including day to day responsibility for trial management. The successful hire will oversee implementation of FIH clinical studies in a high quality, timely and cost-effective manner. The Director, Clinical Operations will ensure that all studies within the program are executed in accordance with US, EU and other governmental regulations as applicable, as well as with appropriate ICH/GCP guidance. This individual will manage cross functional relationships with internal and external stakeholders and will be extremely hands on fostering relationship development with CROs and KOLs. This is a high visibility position with great impact potential. </div><div><br/></div><h3>KEY RESPONSIBILITIES</h3><ul><li>Actively participate in strategic planning activities for assigned programs including budgeting, resource management and vendor identification/management</li><li>Ensure adequate resources for clinical operations including overseeing operational plans, tactical execution of trials, protocol preparation, report writing, regulatory submissions, etc.</li><li>Develop, write, implement and maintain operational procedures and processes within the programs</li><li>Direct clinical program implementation to meet program timelines and budget</li><li>Lead clinical projects as required including developing the clinical research strategy, supporting investigator and site selection, identifying, evaluating, selecting CROs and managing CRO performance.</li><li>Oversee CROs and external vendors on a day-to-day basis including issue tracking/resolution, timeline/budget management</li><li>Domestic and international travel, dependent on program need</li><li>Foster a collaborative culture and serve as a leadership role model</li></ul><h3>REQUIRED QUALIFICATIONS</h3><ul><li>MS or advanced degree in health sciences or related field</li><li>8+ years of clinical trial management experience</li><li>Experience with global clinical trials</li><li>Prior experience selecting and managing CROs</li><li>Expertise in clinical development process, global regulatory requirements, and CRO/vendor management </li><li>Ability to foster effective relationships with vendors, investigators and colleagues</li><li>Ability to contribute technical expertise to the various aspects of the clinical trial process</li><li>Knowledge of industry standards as applied to ICH guidelines, GCPs and the CFR</li><li>Excellent communication, writing and presentation skills</li><li>Ability to assess complex issues and propose viable solutions</li><li>Ability to travel domestically and internationally as needed</li></ul><h3>PREFERRED QUALIFICATIONS</h3><ul><li>Experience with gene editing modalities is highly preferred </li><li>Experience supporting early stage projects </li><li>Familiarity with QbD principles and lifecycle management of analytical methods</li><li>Direct experience with managing CDMOs and CROs</li></ul><h3>BENEFITS</h3><ul><li>Company-paid health/vision/dental benefits</li><li>Unlimited vacation and generous sick time</li><li>Company-sponsored meals and snacks</li><li>Wellness, caregiver and ergonomics benefits</li><li>401(k) with company matching</li></ul><div>Base Salary Range: $192,000 - $240,000 per year</div><div><br/></div><div>Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity. </div><div><br/></div><div>COMPANY</div><div>Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable <i>in vivo</i> gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential <i>in vivo</i> gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.</div><div><br/></div><div>It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.</div><div><br/></div><div><i>Mammoth Biosciences requires that all employees be vaccinated against COVID as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law. </i></div><br/><br/><p>PI9510491b7d61-25401-37646240</p>

Mammoth Biosciences

Director, Clinical Operations

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Analysis Skills

Biotech and Pharmaceutical

Budget Management

Budgeting

Clinical Monitoring

Clinical Research

Clinical Trial

Clinical Trial Management

Code of Federal Regulations

Communication Skills

Contract Research Organization (CRO)

Cross-Functional

Drug Development

Editing

Ergonomics

GCP (Good Clinical Practices)

Government Regulations

Health Science

ICH Regulations

Industry Standards

Intellectual Property (IP)

Leadership

Medical Conditions

Medical Genetics

Operations Planning

Operations Processes

Performance Management

Presentation/Verbal Skills

Problem Solving Skills

Program Planning

Quality Metrics

Regulatory Requirements

Regulatory Submissions

Reporting Skills

Resource Management

Sales Pipeline

Strategic Planning

Tactical Operations

Team Player

Time Management

Vendor/Supplier Management

Vendor/Supplier Relations

Willing to Travel

Writing Skills

JobTarget

INTEGRATED

PERMANENT

FULL_TIME

Systems Software Engineer

We need a "frontline firefighter" who has managed systems at scale (thousands/millions of users) and someone who has experienced the full lifecycle of scaling analytics/event-processing infrastructure. Yuxin previously was a staff engineer/engineering manager for the commerce platform team at Uber, Noah was principal engineer at another YC company, Plangrid.

<b>Founding Equity + Great Benefits</b><br/><br/>This Jobot Job is hosted by: Ryan Kilroy<br/>Are you a fit? Easy Apply now by clicking the "Quick Apply" button
and sending us your resume.<br/>Salary: $180,000 - $250,000 per year<br/><br/><b>A bit about us:</b><br/><br/>We are building the commerce platform for the AI age. The web continues to be the most profitable customer acquisition channel for selling goods and services. Over the past two decades, SaaS products like Squarespace and Shopify have dominated online commerce. They've made it easier to set up an online store, but at their core, they're just CRUD apps built on top of payment processors. You still have to design and build the shop, make ads, write copy, analyze data, and keep iterating until you find a channel that works. This often means spending millions on design, development, marketing, copywriting, ad buying, and more.<br/><br/>What if all this could be done for you? We design and launche your shop and entire marketing campaign, and within a few days provides data about what you should change. We are building an ecommerce specialist in everyone's pocket. Tell us what you're selling, and we will sell it for you — whether that's Tums during the Super Bowl (we did this!) or United Airlines tickets to Tahiti.<br/><br/>To date, we’ve raised over $8.2M from Figma, YCombinator, Vercel, General Catalyst, Infinity Ventures, MAGIC Fund, Base Case Capital. We grew from 5 to over 3000+ customers in less than 18 months.<br/><br/>About the Team<br/>We launched in late 2022 and grew to over 1000+ paying customers, in under a year with no sales or marketing budget. To date, we’ve raised over $8.4M in seed from Figma, YCombinator, Vercel, General Catalyst, Infinity Ventures, MAGIC Fund, Base Case Capital. We're headquartered in San Francisco.<br/><br/><b>Why join us?</b><br/><br/>Selling Points<br/><ul><li>Technical co-founders that have known each other for 14 years (Berkeley CS). Yuxin previously was a staff engineer/engineering manager for the commerce platform team at Uber, Noah was principal engineer at another YC company, Plangrid.</li><li>Skipped our Series A because we had such great metrics. Cap table not over-diluted, and have a lot of equity to dish out to people on the team.</li><li>Over 3000+ customers ranging from SMBs to the MARS company (Skittles, M&Ms). Company is AI-first, 80+ NPS score. Customers love the product.</li><li>In-person in San Francisco. Team is locked in.</li></ul><br/>Who We Need<br/>We are looking for a Backend Engineer with 4+ years of experience (up to 10-11 years). The ideal candidate will have hands-on experience with Kafka, ClickHouse, and event-driven architectures. We need a "frontline firefighter" who has managed systems at scale (thousands/millions of users) and someone who has experienced the full lifecycle of scaling analytics/event-processing infrastructure.<br/><br/>What Disqualifies Candidates<br/><ul><li>Less than 4 years of experience or limited to companies with only dozens of customers.</li><li>Engineers from large public companies who lack hands-on building experience.</li><li>Lack of CS fundamentals required for distributed systems.</li><li>No direct experience with real-time event processing.</li></ul><br/><br/><b>Job Details</b><br/><br/>Why This Role Matters<br/><ul><li>Our current senior engineer is spread thin between product and infrastructure.</li><li>Supporting 10 billion monthly events that power analytics insights.</li><li>Enabling upselling to other Replo products based on customer behavior.</li><li>Building the foundation for our "agency in a box" vision.</li></ul><br/>Ideal Candidate Background<br/><ul><li>CS or STEM degree preferred (or equivalent additional experience).</li><li>From pre-Series D startups that built similar systems.</li><li>Worked at companies like Amplitude, Twilio, Stripe, PostHog, or Sentry.</li><li>Has balanced system reliability with business/product needs.</li><li>Can architect solutions that scale with rapid user growth.</li></ul><br/>Tech Stack: Typescript, Node.Js, Kafka, Clickhouse, Cloudflare, Next.Js, React<br/><br/>Key Signals<br/><ul><li>Has managed systems through unexpected failures and learned valuable lessons.</li><li>Can speak to specific technical challenges they've overcome with Kafka or similar technologies.</li><li>Shows deep understanding of distributed systems principles and failure modes.</li><li>Can translate between technical infrastructure and business needs.</li></ul><br/><br/>Interested in hearing more? Easy Apply now by clicking the "Quick Apply" button.

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Jobot

Senior Backend Engineer

Advertising Creative

Amplitude

Artificial Intelligence (AI)

Channel Sales

Customer Acquisition

Customer/Consumer Behavior

Data Analysis

Distributed Computing

Engineering Management

Firefighting

Marketing

Marketing Campaign

Metrics

News Reporting

Startup

Systems Administration/Management

Systems Reliability

Up-Selling

eCommerce

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