Senior Director, Safety Physician Amylyx PharmaceuticalsSenior Director, Safety PhysicianCambridge, MARemoteReporting to the Vice President, Patient Safety and Pharmacovigilance, the Senior Director, Safety Physician will serve as a medical safety expert across assigned programs and products, partnering closely with colleagues across Clinical Development, Regulatory Affairs, Medical Affairs, Clinical Operations, Biostatistics, and other functions. Experience supporting clinical-stage development programs required; experience supporting late-stage development, regulatory submissions, product launch, and/or marketed products strongly preferred.
Senior Director, Safety Physician Amylyx Pharmaceuticals IncSenior Director, Safety PhysicianCambridge, MARemote$276,000–$310,000 / yearReporting to the Vice President, Patient Safety and Pharmacovigilance, the Senior Director, Safety Physician will serve as a medical safety expert across assigned programs and products, partnering closely with colleagues across Clinical Development, Regulatory Affairs, Medical Affairs, Clinical Operations, Biostatistics, and other functions. Experience supporting clinical-stage development programs required; experience supporting late-stage development, regulatory submissions, product launch, and/or marketed products strongly preferred.
Global Safety Program Lead/Sr Medical Director Alexion Pharmaceuticals IncGlobal Safety Program Lead/Sr Medical DirectorBoston, MA$280,895–$421,342 / yearLeads the safety physicians and scientists to support the safety strategy and input into the program design, monitoring, and data interpretation from pre-clinical and clinical studies, communication and post-marketing surveillance, epidemiology, pre-clinical and literature, epidemiology for each asset. Is accountable for project representation for Global Patient Safety at governance and other forums where safety is involved, eg DRC, eCRC, SARB, FSIRB, and DSMB/DMC, Medical Affairs Review Committees (MARC), product teams such CPT and GPT and Advisory Board meetings in partnership with GSH.
Director, Drug Safety & Pharmacovigilance Scientist Dyne Therapeutics IncDirector, Drug Safety & Pharmacovigilance ScientistWaltham, MA$220,000–$240,000 / yearRole Summary: The Director, Drug Safety & Pharmacovigilance Scientist provides strategic and scientific leadership for safety surveillance, signal detection, benefit-risk evaluation, and risk management activities across Dyne's development programs. The Director collaborates across Clinical Development, Clinical Operations, Regulatory Affairs, Medical Affairs, Biostatistics, Data Management, Quality, and external partners to support proactive safety oversight and informed program decision-making.
Senior Director -Project Toxicologist - Clinical Pharmacology and Safety Sciences (Boston or Gaithersburg) AstraZeneca PlcSenior Director -Project Toxicologist - Clinical Pharmacology and Safety Sciences (Boston or Gaithersburg)Boston, MA$227,602–$341,404 / yearExtensive experience working as a Project Toxicologist across different therapy areas within the pharmaceutical/biotech project environment delivering pre-clinical toxicology packages and successful marketing for a range of modalities which should include small molecules, peptides and oligonucleotides. We value kindness alongside ambition, giving you the trust, tools, and cross-functional partnerships to lead with confidence and shape studies that matter-so your decisions today translate into meaningful patient impact tomorrow.
Medical Director, Global Drug Safety Replimune Group, Inc.Medical Director, Global Drug SafetyWoburn, MA$257,500–$333,500 / yearThe RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. Replimune's mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient's lives depend on it.
Senior Medical Director, Global Drug Safety Replimune Group, Inc.Senior Medical Director, Global Drug SafetyWoburn, MA$307,000–$397,000 / yearThis position provides pharmacovigilance expertise to and lead collaborations with external partners as well as with other functions across Replimune, including Regulatory Affairs, Clinical Development, Clinical Operations, Medical Affairs, or the Commercial to ensure that drug safety communications are accurate, complete and consistent. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Civil Engineer VI - Director, Office of Dam Safety Commonwealth of MassachusettsCivil Engineer VI - Director, Office of Dam SafetyWest Boylston, MACivil Engineer VI'',''Civil Engineer VI'',''United States-Massachusetts-West Boylston-180 Beaman St'',''United States-Massachusetts-West Boylston-180 Beaman St'',''Engineering'',''Engineering'',''Department of Conservation & Recreation'',''Department of Conservation & Recreation'',''Full-time'',''Full-time'',''Multiple'',''Multiple'',''Jul 8, 2026, 10:10:37 AM'',''Jul 8, 2026, 10:10:37 AM'',''1'',''1'',''151,674.90'',''102,592.88'',''151,674.90'',''Yearly'',''Moneesha Dasgupta, DEI Manager, email: EEADiversity@mass.gov'',''Moneesha General duties of the Director include administration of statutory and regulatory dam safety requirements statewide; oversight of state and federal dam-related grant programs; serves as the Commonwealth's USDA-NRCS PL566 Flood Control Program Liaison, provides direct and technical assistance to DCR Operations unit, other state agencies, municipalities, and private dam owners; and oversight of planning, design, and construction of dam repair and removal projects managed by DCR.
NewAssociate Medical Director, Global Patient Safety AlexionAssociate Medical Director, Global Patient SafetyBoston, MassachusettsEvaluates aggregate safety data and provides contributions to core regulatory documents i.e. Periodic Safety Update Reports, Drug Safety Update Reports, Risk Management Plans, and other routine and non-routine safety and risk/benefit evaluations for internal or regulatory purposes as required. The Associate Medical Director, Global Drug Safety is accountable for executing the safety and risk management activities for one or more assigned clinical development projects or marketed products to enable the safe and effective use of Alexion’s products by patients and healthcare providers.
Enterprise Program Director, Patient Safety Mass General BrighamEnterprise Program Director, Patient SafetySomerville, Massachusetts$124,342.40–$180,897.60 / yearSite: Mass General Brigham Incorporated Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success.
Senior Medical Director, Global Drug Safety Replimune Group IncSenior Medical Director, Global Drug SafetyWoburn, MA$307,000–$397,000 / yearThis position provides pharmacovigilance expertise to and lead collaborations with external partners as well as with other functions across Replimune, including Regulatory Affairs, Clinical Development, Clinical Operations, Medical Affairs, or the Commercial to ensure that drug safety communications are accurate, complete and consistent. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Medical Director, Global Drug Safety Replimune Group IncMedical Director, Global Drug SafetyWoburn, MA$257,500–$333,500 / yearThe RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. Replimune's mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient's lives depend on it.
Medical Director, Global Patient Safety AlexionMedical Director, Global Patient SafetyBoston, MassachusettsRepresentingAlexion GPS at internal strategic and/or advisory/governance committees, other project/product team(s) or subteam(s) as a key cross functional member and subject matter expert, and/or act as an external technical resource at DSMB or Regulatory Authority meetings. Evaluating aggregate safety data and providing contributions to core regulatory documents i.e. Periodic Safety Update Reports, Drug Safety Update Reports, Risk Management Plans, and other routine and non-routine safety and risk/benefit evaluations for internal or regulatory purposes as.
Senior Medical Director, Global Drug Safety ReplimuneSenior Medical Director, Global Drug SafetyWoburn, MassachusettsThis position provides pharmacovigilance expertise to and lead collaborations with external partners as well as with other functions across Replimune, including Regulatory Affairs, Clinical Development, Clinical Operations, Medical Affairs, or the Commercial to ensure that drug safety communications are accurate, complete and consistent. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response.
Medical Director, Global Drug Safety ReplimuneMedical Director, Global Drug SafetyWoburn, MassachusettsThe RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it.
Senior Director, Safety Scientist Parabilis MedicinesSenior Director, Safety ScientistCambridge, MA$255,000–$300,000 / yearExperience authoring key safety documents, including Safety Surveillance Plans (SSPs), Signal Analysis Reports (SARs), Development Risk Management Plans (dRMPs), Development Core Safety Information (DCSI), and contributions to Investigator's Brochures (IBs), Development Safety Update Reports (DSURs), clinical protocols, and informed consent forms. This individual will play a critical role in the ongoing assessment of the benefit-risk profile of investigational products by leading signal detection, safety analyses, and risk management activities while partnering closely with Clinical Development, Regulatory Affairs, Biometrics, and Clinical Operations.
Director Safety Physician BioNTech SEDirector Safety PhysicianCambridge, MAOversees quality content of the safety contributions to clinical and regulatory documents such as briefing book for regulatory authority meetings, investigator's brochure, clinical study report safety conclusion section, responses to regulatory authority inquiries, and other clinical/regulatory documents as needed. The MSP also ensures compliance with Good Clinical Practice (GCP) and regulatory reporting requirements, while contributing to essential safety documents such as Development Safety Update Reports (DSURs), updates to reference safety information, Investigator Brochures, and Clinical Trial Reports.
Associate Director, Safety Science Rhythm PharmaceuticalsAssociate Director, Safety ScienceBoston, MA$160,000–$240,000 / yearLead/co-lead planning and preparation of key global PV documents, including but not limited to Periodic Benefit-Risk Evaluation Reports (PBRERs), Periodic Safety Update Report (PSUR), Development Safety Update Reports (DSURs), and Risk management Plans (RMPs). Identify, evaluate and manage emerging safety signals, maintain good documentation, and communicate any changes in the safety profile or benefit-risk assessment effectively (written and verbal) both internally and externally.
Associate Director, Safety Science Rhythm Pharmaceuticals IncAssociate Director, Safety ScienceBoston, MA$160,000–$240,000 / yearLead/co-lead planning and preparation of key global PV documents, including but not limited to Periodic Benefit-Risk Evaluation Reports (PBRERs), Periodic Safety Update Report (PSUR), Development Safety Update Reports (DSURs), and Risk management Plans (RMPs). Identify, evaluate and manage emerging safety signals, maintain good documentation, and communicate any changes in the safety profile or benefit-risk assessment effectively (written and verbal) both internally and externally.
Medical Director, Global Patient Safety Alexion Pharmaceuticals IncMedical Director, Global Patient SafetyBoston, MAEvaluating aggregate safety data and providing contributions to core regulatory documents i.e. Periodic Safety Update Reports, Drug Safety Update Reports, Risk Management Plans, and other routine and non-routine safety and risk/benefit evaluations for internal or regulatory purposes as required. Representing Alexion GPS at internal strategic and/or advisory/governance committees, other project/product team(s) or subteam(s) as a key cross functional member and subject matter expert, and/or act as an external technical resource at DSMB or Regulatory Authority meetings.