Clinical responsibilities include ventilator management, arterial line management, central line care, blood product administration, continuous sedation, vasoactive medication titration, cardiac medication titration, stroke management, respiratory failure care, renal failure care, dysrhythmia management, chest tube support, tracheostomy care, and procedural sedation monitoring. Required skills include managing noninvasive ventilation, high-flow nasal cannula therapy, arterial blood gases, isolation precautions, intravenous insulin protocols, peripherally inserted central catheter lines, emergency medications, phlebotomy, and suctioning.