A multidisciplinary P01 program focused on influenza transmission as part of the NIAID Influenza Transmission Research Consortium (ITRC), together with complementary NIH R01-supported research, provides opportunities to integrate human studies with controlled swine and ferret transmission models, develop new approaches for measuring infectious aerosols, and define the mechanisms that govern airborne influenza transmission. The research program has access to newly established ABSL-2 animal transmission facilities, BSL-3 and ABSL-3 biocontainment facilities, aerosol sampling and engineering capabilities, advanced laboratory automation systems, and institutional core facilities supporting genomics, proteomics, metabolomics, imaging, bioinformatics, and computational biology.