NewResearch Principal Scientist Waters CorporationResearch Principal ScientistMilford, MADesign materials with optimized specific applications in reversed-phase, Ion-exchange, HILIC, affinity, mixed-mode, and sample preparation workflows for separations of proteins, monoclonal antibodies, oligonucleotides, peptides, PFAS, and small molecules. Members of Global Research work in highly collaborative cross-functional teams spanning Consumables, Liquid Chromatography, Mass Spectrometry, Clinical, and Informatics technologies to develop novel solutions for complex analytical problems.
NewSenior Principal Scientist Waters CorporationSenior Principal ScientistMilford, MAIn addition to leading innovation in material design, you will help advance next-generation manufacturing strategies for Waters particle and bonded-phase production, including scalable and data-rich manufacturing approaches, advanced process characterization, and in-process analytical testing methodologies. As a Senior Principal Scientist within the BioSeparations Portfolio of the Chemistry & Lab Automation Business Unit, you will define and lead the scientific strategy for novel chromatographic materials and enabling chemistries for biologics ranging from oligonucleotides, viral vectors, and mRNA to proteins, peptides, and gene-editing therapeutics.
Principal Scientist, Biophysicist Novartis AGPrincipal Scientist, BiophysicistCambridge, MA$119,700–$222,300 / yearD. (post-doc preferred), in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or a related field), with 2+ years of industrial experience in drug discoveryDeep expertise in designing, validating, executing and troubleshooting biophysical assays. Internal Job Title: Principal Scientist I/Principal Scientist IIPosition Location: onsite, La Jolla, CA #LI-onsiteWe are seeking a highly motivated and experienced Principal Scientist / Biophysicist to join our dynamic team in La Jolla, CA.
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting) Novartis AGPrincipal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)Cambridge, MA$126,000–$234,000 / yearEngage in strategic initiatives within M&S, such as creating platform-level translational modeling strategies to impact across projects and developing modeling workflows (e.g., agentic AI).• Proactively seek opportunities to increase the understanding and adoption of translational modeling among internal partners and expand the impact and visibility of modeling through external collaborations. As part of a truly translational modeling team, you will also work closely with clinical pharmacology and pharmacometrics groups to support clinical programs, applying quantitative systems pharmacology (QSP) and mechanistic PBPK/PD approaches to inform key decisions from early dose optimization through life-cycle management.
Raven StealthCo - Principal Scientist, Analytical Chemistry RavenRaven StealthCo - Principal Scientist, Analytical ChemistryBoston, Massachusetts$160,000–$190,000 / yearThe Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs. As such, the Principal Scientist, Analytical Chemistry should be highly nuanced in terms of their interpersonal style and able to lead and work effectively within a highly collaborative, entrepreneurial, and fast-paced start-up environment.
Principal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular Design Antares TherapeuticsPrincipal Scientist/Sr. Principal Scientist, Computational Chemistry & Molecular DesignBoston, Massachusetts$185,000–$240,000 / yearAs a member of a highly integrated team of medicinal chemists, machine learning scientists, structural biologists, biologists, and chemical biologists, you will apply and advance the full range of modern computational methods — structure- and ligand-based design, molecular dynamics, free energy perturbation (FEP), and machine-learning / generative approaches — to assess and prioritize targets, identify high-quality starting points, and drive lead optimization toward development candidates. Serve as the computational chemistry function lead on programs, providing integrated leadership across target validation, hit identification, hit-to-lead, and lead optimization for multiple small-molecule programs.
Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting) Novartis AGPrincipal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)Cambridge, MA$119,700–$222,300 / yearWorks in close collaboration with clinicians and clinical development colleagues to integrate PKS insights into study design, data interpretation, and project decision‑makingModels the use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, and authoring regulatory documents. Key responsibilities:Brings strong AI and digital fluency, using enterprise tools to further strategic, scientific and operational leadership in clinical pharmacologyIdentifies, develops and implements high-value use cases where AI can materially improve clinical pharmacology planning, analyses and decision quality.
Senior/Principal Scientist Cell Based Potency Assay 3316 Takeda Development Center AmericasSenior/Principal Scientist Cell Based Potency AssayLexington, MassachusettsD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics SanofiSenior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsCambridge, MA$148,500–$214,500 / yearYou will operate in an agile, fast-paced environment with access to industry-leading data infrastructure, working in close collaboration with disease area experts, medical teams, and therapeutic program leads to ensure your work translates into tangible impact on patients' lives. Working alongside world-class computational and experimental scientists, you will help shape the future of drug discovery and development across Sanofi's therapeutic areas - from early indication prioritization to business development evaluation of external assets.
Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
NewPrincipal Scientist, Antibody Discovery and Engineering ModernaTXPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MassachusettsThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Scientist, Systems and Disease Biology SanofiPrincipal Scientist, Systems and Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Senior Scientist/Principal Scientist, Protein Science Synolo Therapeutics IncSenior Scientist/Principal Scientist, Protein ScienceCambridge, MAAbout RA Capital: RA Capital Management funds and builds healthcare and life science companies using an evidence-based investment approach informed by TechAtlas, a think tank within RA Capital which analyzes scientific and clinical data from academic literature and industry sources to anticipate how breakthroughs might impact industry stakeholders, physicians, patients, and policymakers. Experience working with large, multidimensional datasets and leveraging modern computational and AI-enabled tools (e.g., Python, workflow automation, AI coding assistants, interactive scientific applications, and data visualization platforms) to improve scientific productivity, data analysis, and decision-making.
Principal Scientist, ADCs Discovery Biology, Oncology Thematic Research Center Bristol-Myers Squibb CoPrincipal Scientist, ADCs Discovery Biology, Oncology Thematic Research CenterMA$156,180–$189,252 / yearThe scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
Principal Scientist, Adcs Discovery Biology, Oncology Thematic Research Center Bristol Myers SquibbPrincipal Scientist, Adcs Discovery Biology, Oncology Thematic Research CenterCambridge Crossing, MA$156,180–$189,252 / yearThe scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. In the role as a Principal Scientist within Discovery Biology, the ideal candidate will: Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation.
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison Merck & Co IncSr. Principal Scientist (Sr. Director) - Regulatory LiaisonBoston, MA$190,800–$300,300 / yearRequired Skills: Biological Sciences, Clinical Reporting, Drug Development, Global Health, In Vitro Diagnostics (IVD), Multiple Therapeutic Areas, Pharmaceutical Regulatory Affairs, Process Improvements, Product Approvals, Regulatory Affairs Compliance, Regulatory Affairs Management, Regulatory Communications, Regulatory Compliance, Regulatory Issues, Regulatory Strategies, Regulatory Strategy Development, Written Communication. As the Global Regulatory Lead (GRL), the Senior Principal Scientist functions as the regulatory single, accountable, global point of contact on the project team and interacts with the global regulatory agencies and/or subsidiaries with regard to global regulatory strategy/registration requirements for one or more company investigational and marketed drugs/biologics in early- and/or late-stage development.
Raven StealthCo - Principal Scientist, In Vivo Pharmacology RavenRaven StealthCo - Principal Scientist, In Vivo PharmacologyBoston, Massachusetts$170,000–$185,000 / yearThe team is small, the work deeply cross-functional, and priorities shift, so we want someone thoughtful, highly organized, and energized by a fast-paced start-up, with significant latitude to shape how we run in vivo pharmacology and a clear path to grow in scope and leadership as the organization matures. As one of our earliest and more senior hires, this person helps shape a culture we are deliberate about: rooted in psychological safety, where good ideas are welcomed from any seat, respect is paramount, failure is a chance to learn rather than a cause for blame, and mentorship is the spine of strong teams.
Senior/Principal Scientist Cell Based Potency Assay Takeda Pharmaceutical Co LtdSenior/Principal Scientist Cell Based Potency AssayLexington, MA$154,400–$242,550 / yearD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Principal Scientist I/II, Oligonucleotide Chemistry & Innovation Novartis AGPrincipal Scientist I/II, Oligonucleotide Chemistry & InnovationCambridge, MA$108,500–$201,500 / yearExpected Annual Base Salary Range for role: US: 108,500.00 - 201,500.00 USD AnnualThe salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically. Working alongside a collaborative team of world-class scientists, you will lead the development of novel oligonucleotide chemistries, drive therapeutic innovation, and help shape the future of RNA medicines in a dynamic and fast-paced research environment.
Principal Scientist (Director), Translational Medicine - Infectious Diseases Merck & Co IncPrincipal Scientist (Director), Translational Medicine - Infectious DiseasesBoston, MA$260,300–$409,700 / yearPrimary responsibilities for the Principal Scientist include the following: Working with basic science teams on specific diseases and therapeutic areas, providing clinical expertise for identification and validation of novel targets, including the design of preclinical and clinical experiments to validate targets and/or pathways, and leveraging this work for development of novel therapeutics. Translational Medicine is specifically responsible for: Contributing to the identification of novel targets by partnering with Discovery Sciences to bring a clinical perspective into the earliest stages of target identification and validation, and to execute clinical studies to evaluate the relevance of potential targets to human disease in order to justify full development.