Principal Scientist, Biophysicist Novartis AGPrincipal Scientist, BiophysicistCambridge, MA$119,700–$222,300 / yearD. (post-doc preferred), in a relevant scientific discipline (e.g., Biophysics, Biochemistry, Bioengineering, or a related field), with 2+ years of industrial experience in drug discoveryDeep expertise in designing, validating, executing and troubleshooting biophysical assays. Internal Job Title: Principal Scientist I/Principal Scientist IIPosition Location: onsite, La Jolla, CA #LI-onsiteWe are seeking a highly motivated and experienced Principal Scientist / Biophysicist to join our dynamic team in La Jolla, CA.
Principal Scientist - Translational Biology & Program Leadership WuXi Biologics Cayman IncPrincipal Scientist - Translational Biology & Program LeadershipNatick, MA$95,000–$155,000 / yearJob Summary: We are seeking a strategic and scientifically driven Principal Scientist with strong expertise in translational immunology, ex vivo biology, and therapeutic program leadership to lead cross-functional drug discovery initiatives across oncology, autoimmune, and inflammatory disease programs. In addition to technical expertise in ex vivo immune assays and complex 3D model systems, the ideal candidate will possess demonstrated experience leading multidisciplinary discovery teams, coordinating program activities across functions, and influencing strategic direction in a fast-paced biotechnology environment.
Principal Scientist, Structural Biology Novartis AGPrincipal Scientist, Structural BiologyCambridge, MA$119,700–$222,300 / yearKey Responsibilities:Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule, protein-peptide, and/or protein-protein interactions, supporting drug discovery initiativesSuccessfully drive gene-to-structural small molecule drug discovery projectsLeverage knowledge in protein production and structural biology to characterize structure-function relationships, investigate novel mechanisms of action, and address complex scientific questionsCollaborate with cross-functional teams, including protein scientists, biophysicists, chemists, and computational modelers, to facilitate structure-based drug designAdvance our initiatives and drug discovery programs by leveraging innovative approaches, such as applications of AI.Essential Requirements:Ph. D. in structural biology, biophysics, biochemistry, or a related field with over 5 years of relevant experience in X-ray crystallography within either industrial or academic settingsDemonstrated expertise in protein expression across E. coli, insect, and mammalian expression systems, as well as extensive experience in protein purification and characterizationProven track record in application of X-ray crystallography to characterize protein-ligand and protein-protein complexes, including crystallization screening and optimization, data processing, structure refinement and analysis.
Raven StealthCo - Principal Scientist, Analytical Chemistry RavenRaven StealthCo - Principal Scientist, Analytical ChemistryBoston, MassachusettsThe Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs. As such, the Principal Scientist, Analytical Chemistry should be highly nuanced in terms of their interpersonal style and able to lead and work effectively within a highly collaborative, entrepreneurial, and fast-paced start-up environment.
Principal Scientist, Structural Biologics Novartis AGPrincipal Scientist, Structural BiologicsCambridge, MA$108,500–$201,500 / yearEssential Requirements:PhD degree in biophysics, biochemistry, or related discipline with a proven record in experimental structural biology.3+ years experience (Postdoc or industry experience) in common protein purification methods (Affinity, IMAC, SEC) and molecular biology techniques (cloning, DNA isolation, transformation, etc.).Interest in using AI/ML methods in a structural biology context. Internal Job Title: Principal Scientist IPosition Location: San Diego, CA onsiteThe Biologics Research Center, Structural Biologics department is looking for a highly motivated Principal Scientist to support experimental structural biology across multiple biotherapeutic programs.
Principal Scientist I/II - Oncology Novartis AGPrincipal Scientist I/II - OncologyCambridge, MA$108,500–$201,500 / yearKey responsibilities:Supervise translational experimental plan and biomarker strategies for various RLT drug discovery programsDesign and conduct translational studies including in vitro assays with RLT, dissection of mechanism of action, and testing of drug combinationsCollaborate with groups across Mariana and BR OncologyEssential Requirements:This is a dual post. The final level and title of the role offered will be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level offered (Principal Scientist I/II):Principal Scientist I: Post Doc experience or 3 years of relevant experience in academia or industry.
Principal Scientist - Global Drug Discovery, Obesity Pharmacology (US) Novo Nordisk ASPrincipal Scientist - Global Drug Discovery, Obesity Pharmacology (US)Lexington, MAInternal relationships include working closely with technical staff and other members of the scientific leadership team, regular collaborations with members of other research departments, and frequent interaction with project managers and colleagues across global R&D. The Principal Scientist will provide scientific leadership in the identification, validation, and advancement of new drug targets related to obesity and obesity-related comorbidities, including cardiovascular disease (CVD) and metabolic dysfunction-associated steatohepatitis (MASH).
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development Takeda Pharmaceutical Co LtdSenior/Principal Scientist, Analytical Cell Line Engineering and Bioassay DevelopmentLexington, MA$154,400–$242,550 / yearHow you will contribute: Lead the design, generation, characterization, and lifecycle management of stable mammalian analytical cell lines expressing targets of interest, receptor systems, or reporter constructs to support potency and functional bioassays. Operating at the interface between Discovery, Global Biologics, Analytical Development, and late-stage potency teams, this role translates product mechanism of action into scientifically sound, phase-appropriate cell line and assay strategies.
Principal Scientist I - Downstream Processing Novartis AGPrincipal Scientist I - Downstream ProcessingCambridge, MAKot Vodilni raziskovalec morate izkazovati iroko in poglobljeno poznavanje tehnologij proizvodnje in ienja rekombinantnih proteinov, da boste lahko ocenili razvojni potencial razlinih biolokih terapevtskih kandidatov, ki jih pokrivajo enote Novartis Biomedicinske raziskave in Razvoj, od tradicionalnih protiteles do naprednih biolokih formatov in meanih modalnosti, pri emer zagotavljate kakovost dostavljenega materiala in na koncu omogoate izbor vodilnega kandidata. As a Principal Scientist you must demonstrate a broad and in-depth knowledge of technologies in recombinant protein production and purification to evaluate the developability of various biologics modalities covered by Novartis Biomedical Research and Development units, ranging from traditional antibodies to advanced biologics formats and mixed modalities, ensuring quality of material delivered and eventually enabling lead candidate selection.
Principal Scientist, Systems and Disease Biology SanofiPrincipal Scientist, Systems and Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
NewPrincipal Scientist, Antibody Discovery and Engineering ModernaTXPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MassachusettsThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
Principal Scientist, Systems And Disease Biology SanofiPrincipal Scientist, Systems And Disease BiologyCambridge, MA$122.25–$176.58 / hourD. in systems biology, computational biology, biostatistics, or related quantitative field with proven experience in a relevant disease area (Immunology, Neurology or Oncology) OR PhD in biological sciences, biomedical sciences, immunology, neuroscience, oncology or in a related disease area and proven advanced track record of data analytics, ML/AI, or computational biology. Leading projects involving internal experiment design and data analytics as well as outsourcing of established workflows and/or complex follow-up mechanistic assays (organoid, CRISPR, proteomics).
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison Merck & Co IncSr. Principal Scientist (Sr. Director) - Regulatory LiaisonBoston, MA$190,800–$300,300 / yearRequired Skills: Biological Sciences, Clinical Reporting, Drug Development, Global Health, In Vitro Diagnostics (IVD), Multiple Therapeutic Areas, Pharmaceutical Regulatory Affairs, Process Improvements, Product Approvals, Regulatory Affairs Compliance, Regulatory Affairs Management, Regulatory Communications, Regulatory Compliance, Regulatory Issues, Regulatory Strategies, Regulatory Strategy Development, Written Communication. As the Global Regulatory Lead (GRL), the Senior Principal Scientist functions as the regulatory single, accountable, global point of contact on the project team and interacts with the global regulatory agencies and/or subsidiaries with regard to global regulatory strategy/registration requirements for one or more company investigational and marketed drugs/biologics in early- and/or late-stage development.
Principal Scientist - In Vivo Expert, CVRI (Cardiovascular, Renal & Immunology) Bayer AGPrincipal Scientist - In Vivo Expert, CVRI (Cardiovascular, Renal & Immunology)Cambridge, MA$139,840–$209,760 / yearThe primary responsibilities of the Principal Scientist are to: Responsible for identifying and setting up relevant mechanistic and disease in vivo models to support cardiovascular and renal projects from target identification to preclinical candidate acceptance and early clinical development including hands-on experimentation, analysis of data and presentation to cross-functional project teams; Prepare and update experimental protocols; Independently perform data analysis and effectively interpret results; Support evaluation of external innovation landscape in the field of in vivo models and connection to external partners (CROs, academic partners); Lead novel target proposals and experimental validation to support growth of our early cardiovascular & renal portfolio including presentation at internal governance; Support BD&L assessment of external targets and programs to understand the competitive landscape and identify potential opportunities for collaboration or technological innovation; Engage in close collaboration with scientists and technical staff of the In Vivo Cluster based at the German sites to share knowledge, drive progress and stimulate innovation; Lead publication of results, prepare reports and presentations at both internal and external forums; Coach research associates in a matrix organization; Collaborate effectively with colleagues and interdisciplinary teams both within Bayer and with external collaborators; Ensure that all tasks are aligned with respect to HSE guidelines, animal welfare law and regulations, documentation guidelines, and good research practices. Specifically, the candidate will design and conduct experimental research studies at the bench, coach research associates, and propose therapeutics project(s) targeting cardiac or renal (including cardio-renal metabolic) disease.
Senior/Principal Scientist Cell Based Potency Assay Takeda Pharmaceutical Co LtdSenior/Principal Scientist Cell Based Potency AssayLexington, MA$154,400–$242,550 / yearD. in cell biology, molecular biology, immunology, biochemistry, bioengineering, pharmaceutical sciences, statistics, biostatistics, or a related discipline with 3+ years of relevant experience for Senior Scientist or 7+ years for Principal Scientist; MS with 9+ years for Senior Scientist or 13+ years for Principal Scientist; or BS with 11+ years for Senior Scientist or 15+ years for Principal Scientist. Plan and coordinate work with departmental, cross-functional, and external stakeholders, including Process Development, Quality Control, contract testing laboratories, Analytical Sciences, Quality Assurance, Regulatory, and other Analytical Development teams.
Preclinical Safety Profiling Expert, Principal Scientist Novartis AGPreclinical Safety Profiling Expert, Principal ScientistCambridge, MA$114,100–$211,900 / yearParticipate in cross-functional early safety screening & profiling collaborations with Novartis Biomedical Research partners to support the early derisking of compounds, drug targets, and therapeutic modalitiesDeliver clear and concise presentations for audiences with different expertiseIn collaboration with cross-functional partners, provide scientific and strategic input to support the early derisking of compounds, drug targets, and therapeutic modalitiesEnsure quality and compliance of data generation, analyses and resultant reportsEssential RequirementsDegree/Advanced Degree in Pharmacology, Toxicology or a Related Field5+ years of relevant experience in pharmacology / toxicologyUnderstands the basic concepts of hazard identification and risk assessment associated with drug ADME, off-target mitigation and cardiovascular safety. Cambridge MAInternal: Principal Scientist I or IILI#-HybridThe Preclinical Safety (PCS) department within the Novartis Biomedical Research Translational Medicine Unit provides world class preclinical safety profiling and assessment for optimal drug discovery, development and commercialization, with state-of-the-art regulatory compliance.
Senior Principal Scientist - Proteomics Novartis AGSenior Principal Scientist - ProteomicsCambridge, MAExpected Annual Base Salary Range for role: CHF 126.000 - CHF 234.000 The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically. This role involves collaboration with scientists, project teams, and five disease areas across Novartis Biomedical Research, all dedicated to creating and delivering transformative therapeutics to patients worldwide.
Principal Scientist I or II, PK Sciences Therapeutic Areas (Multiple Listings) Novartis AGPrincipal Scientist I or II, PK Sciences Therapeutic Areas (Multiple Listings)Cambridge, MA$108,500–$201,500 / yearA minimum of 0-2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma).• 2+ years of experience preferably in a lead role overseeing ADME/DMPK project strategy, either in discovery or clinical development to be considered for Principal Scientist II• Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences.• • Works in close collaboration with clinicians and clinical development colleagues to integrate PKS insights into study design, data interpretation, and project decision‑making• Use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, authoring regulatory documents, and the use of predictive modelsThis role reports to Therapeutic Area group in PK Sciences within Translational Medicine (TM) in Biomedical Research.
Principal Scientist - AI-Powered Discovery for Neurodegeneration SanofiPrincipal Scientist - AI-Powered Discovery for NeurodegenerationCambridge, MA$122,250–$176,583.33 / yearYou will join a team to lead the analyses of large scale public and internal data sets from human brain tissue single cell and spatial omics (rna, protein and lipids), fluid proteogenomic biomarkers (CSF and plasma), and functional screening (CRISPR) in human disease relevant cell models. Integrate single-cell genomics with plasma and CSF proteomics and clinical outcomes from public and in-house datasets to identify cell state shifts and molecular features associated with disease progression, contributing to refining patient selection criteria for future trial designs.
Senior Principal Scientist SanofiSenior Principal ScientistCambridge, MA$148.50–$214.50 / hourIn parallel, the candidate will build relationships with key opinion leaders in the field and work to source disease relevant cell lines, models, and patient samples and work with research and translational sciences to expedite internal research and accelerate later-stage research programs. This individual will work cross-functionally to identify and shepherd early-stage programs into the research pipeline, through internal and external innovation, and ensure the successful progression of development stage programs through the clinic to registration by providing deep research subject matter expertise.
Principal Scientist - Ai-Powered Discovery For Neurodegeneration SanofiPrincipal Scientist - Ai-Powered Discovery For NeurodegenerationCambridge, MA$122,250–$176,583.33 / yearYou will join a team to lead the analyses of large scale public and internal data sets from human brain tissue single cell and spatial omics (rna, protein and lipids), fluid proteogenomic biomarkers (CSF and plasma), and functional screening (CRISPR) in human disease relevant cell models. Integrate single-cell genomics with plasma and CSF proteomics and clinical outcomes from public and in-house datasets to identify cell state shifts and molecular features associated with disease progression, contributing to refining patient selection criteria for future trial designs.
Principal Scientist, Discovery Biosciences - Integrative New Targets, Oncology Bristol Myers SquibbPrincipal Scientist, Discovery Biosciences - Integrative New Targets, OncologyCambridge Crossing, MA$156,180–$189,252 / yearPosition Responsibilities: In the role as a Principal Scientist within Discovery BioSciences, the ideal candidate will: Drive high-quality data science that is grounded in deep understanding of biology/mechanisms by contributing, developing and pressure testing applied data science methodologies and approaches to identify new targets for oncology drug development. Experience in executing target identification strategies including the design, implementation, and validation of targets from forward and reverse genetic and/or phenotypic screens by use of genome engineering techniques, molecular biology, and genetic perturbation (eg shRNA, CRISPR, degron tagging of endogenous loci) is required.
NewPrincipal Scientist, Antibody Discovery and Engineering Moderna IncPrincipal Scientist, Antibody Discovery and EngineeringCambridge, MA$142,500–$256,500 / yearThis individual will operate with a high degree of independence, scientific judgment, and cross-functional influence while partnering with antigen design, structural and computational biology, Immuno-oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.
NewPrincipal Scientist - Formulation Tetraphase Pharmaceuticals IncPrincipal Scientist - FormulationLexington, MANortiva's novel ultra-long-acting oral drug delivery platform uniquely combines elements of controlled drug delivery, traditional and non-traditional formulation components and processes, and dynamic structural features required for gastric residence. Nortiva's drug delivery platform combines traditional and non-traditional formulation processes such as hot-melt-extrusion, coextrusion, injection molding, spray coating, and laser welding.
NewSenior / Principal Scientist, Biochemistry Treeline Biosciences, Inc.Senior / Principal Scientist, BiochemistryWatertown, MA$158,000–$184,000 / yearThe successful candidate for the Senior / Principal Scientist, Biochemistry position will have a critical role in supporting Treeline's drug discovery programs by collaborating closely with a multi-disciplinary team of biology, biophysics, structural biology, computational, and medicinal chemistry scientists to deliver high-quality results and drive small molecule drug discovery. Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases.
Principal Scientist, Ai-Driven Oncology Target Discovery Bristol Myers SquibbPrincipal Scientist, Ai-Driven Oncology Target DiscoveryCambridge Crossing, MA$166,770–$202,086 / yearIPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
Principal Scientist, Computational Designer (Biologics & Peptides) Bayer AGPrincipal Scientist, Computational Designer (Biologics & Peptides)Cambridge, MA$139,840–$209,760 / yearIn this role, you will partner closely with protein engineers, peptide chemists, structural biologists, assay teams, and key discovery partners in antibody or peptide generation and engineering to translate hypotheses into designed sequences and prioritize candidates for experimental testing. Expertise in protein and peptide structure modeling, antibody design, molecular dynamics, free-energy and physics-based scoring, and machine-learning-guided design, including proficiency with state-of-the-art AI tools for co-folding, structure prediction, and de novo binder generation.
Senior/Principal Scientist, Small Molecule Therapeutics Lila SciencesSenior/Principal Scientist, Small Molecule TherapeuticsCambridge, MassachusettsFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. Automation-forward mindset: experience operating in automation- and robotics-enabled labs, including liquid handling integration, assay automation, and designing scalable, reproducible experimental workflows.
NewSenior/Principal Scientist, MPN Biology, Translational Sciences PharmaEssentia U.S.A.Senior/Principal Scientist, MPN Biology, Translational SciencesBEDFORD, MAFull timeFounded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung. In this position, you will utilize your expertise in MPN stem cell biology, driver mutation signaling pathways, in vivo MPN mouse models and biomarker discovery to guide proof-of-concept (POC) studies, drug development and biomarker strategies, optimize dosing regimens, and ensure the safety and efficacy of investigational drugs.
Principal Scientist II - Pharmacology Novartis AGPrincipal Scientist II - PharmacologyCambridge, MA$126,000–$234,000 / yearResponsibilities:Design pre-clinical in vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof-of-concept of new modalitiesDevelop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, relevant biomarkers, and key translational questionsManage associate-level scientistsCollaborate with cross-functional project teamsCritically analyze and present results within a multidisciplinary team environmentCareful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebookQualifications:PhD with 5-8 years of research experience as a postdoc or in the pharmaceutical/biotech industryDeep knowledge of antibody drug conjugatesExtensive experience working with CDX and PDX xenograft tumor models and/or syngeneic modelsExpertise in cell culture, PCR, ELISA, western blot, and flow cytometryStrong analytical, communication (written and verbal), and organizational skills, including a proficiency with PowerPoint and commonly used data analysis programs, such as Prism and ExcelNovartis Compensation and Benefit Summary: The salary for this position is expected to range between $126,000 and $234,000 per year. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline.
NewPrincipal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics Novartis AGPrincipal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA TherapeuticsCambridge, MA$93,800–$174,200 / yearLI-OnsiteLocation: Basel, SwitzerlandRole Purpose:Novartis xRNA Therapeutics is seeking a passionate, highly motivated and experienced PhD-level scientist to lead mid/large scale oligonucleotides synthesis activities and manage a team at our Basel site to support our xRNA Therapeutics development. Key ResponsibilitiesPlan and execute medium- and large-scale solid-phase synthesis, purification, and analysis of chemically modified oligonucleotides (siRNAs, ASOs, and other emerging synthetic modalities) and conjugates to support our xRNA therapeutics portfolio.
NewSenior/Principal Scientist, MPN Biology, Translational Sciences PharmaEssentia CorpSenior/Principal Scientist, MPN Biology, Translational SciencesBEDFORD, MASummary of Key Responsibilities: Study Design and Execution: Lead the design, planning, and execution of POC and translational studies in healthy and MPN mouse models and primary human cellular and tissue systems to generate comprehensive pharmacology and biomarker data packages including MOA and differentiation from competitor programs. Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung.
Senior/Principal Scientist, Small Molecule Therapeutics Lila Sciences IncSenior/Principal Scientist, Small Molecule TherapeuticsCambridge, MA$148,000–$208,000 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. Automation-forward mindset: experience operating in automation- and robotics-enabled labs, including liquid handling integration, assay automation, and designing scalable, reproducible experimental workflows.
Principal Scientist SanofiPrincipal ScientistWaltham, MA$122.25–$176.58 / hourThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Main responsibilities: Lead scale-up activities from bench scale to pilot scale (200L-2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Principal Scientist, Lab Head, Integrative Neuroscience SanofiPrincipal Scientist, Lab Head, Integrative NeuroscienceCambridge, MA$122.25–$176.58 / hourBut progress doesn't happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. Collaborate effectively within matrixed, dynamic, and cross-functional teams across the Neurology therapeutic area, platform groups, and external partners.
Principal Scientist, In Vivo Pharmacology, Oncology Merck & Co IncPrincipal Scientist, In Vivo Pharmacology, OncologyBoston, MA$176,200–$277,300 / yearRequired Skills: Cancer Research, Drug Discovery Process, Immunoassays, Immunohistochemistry (IHC), In Vivo Models, Leading Project Teams, Mass Spectrometry Imaging, Molecular Biology Techniques, Mouse Models, Multiplex Assays, Oncology, Pharmacokinetics, Pharmacology, Tumor Biology. The role will involve building alliances with Discovery Oncology teams at the Boston and South San Francisco sites, championing new technologies (e.g., spatial biology using novel multi-plex immunohistochemistry capabilities), and interfacing with our global pharmacology network.
Principal Scientist, Protein Design ModernaTXPrincipal Scientist, Protein DesignCambridge, MassachusettsThis role will lead the design, execution, and continuous advancement of high-throughput mammalian cell–based screening platforms that interrogate broadly applicable design principles for glycoprotein antigens, enabling antigen optimization, improved expression and durability across multiple programs, and rapid maturation of computationally designed candidates. The candidate in this position will work closely with and report to the Senior Director, Computational Design and In Vitro Selection, and will also work closely with the VP, Protein Design, as well as other members of Research, to advance novel candidates to the clinic, drive exploratory trials to inform the generation of improved vaccine antigens and explore new concepts for mRNA medicines.
Senior Principal Scientist, Analytical Sciences Eli Lilly and CoSenior Principal Scientist, Analytical SciencesWatertown, MA$71,250–$187,000 / yearOur current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL). Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.
Principal Scientist NET2SOURCE INCPrincipal ScientistBoston, MAExperience in molecular endpoints, including, PCR, qPCR, ddPCR, and protein analysis (Simple Western Jess, ELISA, MSD, Octet). Perform cell culture and molecular biology experiments and establish new functional assays to measure gene therapy outcomes both in vitro and in vivo.
Senior Principal Scientist - Translational Muscle Biology UCB SASenior Principal Scientist - Translational Muscle BiologyCambridge, MAThe candidate will bring hands-on scientific leadership to a matrixed team focused on identifying and building knowledge across pathobiological pathways and patient populations, including neuromuscular diseases related to nucleotide repeat expansions, genetic mutations, muscle atrophy, mitochondrial/lysosomal dysfunction, or inflammation. This is an opportunity for a scientific leader to advance portfolio projects and lead from the bench-exploring new biology and directly shaping the design, development, and execution of in vitro and in vivo models as well as cellular and biochemical assays for early drug discovery across multiple therapeutic programs and target discovery efforts.
Principal Scientist, Discovery BioSciences - Integrative New Targets, Oncology Bristol-Myers Squibb CoPrincipal Scientist, Discovery BioSciences - Integrative New Targets, OncologyMAIn the role as a Principal Scientist within Discovery BioSciences, the ideal candidate will: Drive high-quality data science that is grounded in deep understanding of biology/mechanisms by contributing, developing and pressure testing applied data science methodologies and approaches to identify new targets for oncology drug development. Experience in executing target identification strategies including the design, implementation, and validation of targets from forward and reverse genetic and/or phenotypic screens by use of genome engineering techniques, molecular biology, and genetic perturbation (eg shRNA, CRISPR, degron tagging of endogenous loci) is required.
Principal Scientist, Separation Methods Expert, Analytical Science and Technology (AS&T), Vertex Pharmaceuticals (Boston) Vertex Pharmaceuticals IncPrincipal Scientist, Separation Methods Expert, Analytical Science and Technology (AS&T), Vertex Pharmaceuticals (Boston)Boston, MA$138,400–$207,600 / yearAdditionally, the principal scientist will partner closely with all stakeholders, and with contract testing sites establishing partnerships to ensure compliance with cGMP and Quality Management systems for the global network to deliver our medicines to patients effectively. General Summary: The Analytical Science and Technology (AS&T) Principal Scientist, Separation Method Expert, will be responsible for providing scientific and technical expertise within and across functional areas for late-stage & commercial methods and vendor management.
Principal Scientist, Separation Methods Expert, Analytical Science And Technology (As&T), Vertex Pharmaceuticals (Boston) Vertex Pharmaceuticals, IncPrincipal Scientist, Separation Methods Expert, Analytical Science And Technology (As&T), Vertex Pharmaceuticals (Boston)Boston, MA$138,400–$207,600 / yearAdditionally, the principal scientist will partner closely with all stakeholders, and with contract testing sites establishing partnerships to ensure compliance with cGMP and Quality Management systems for the global network to deliver our medicines to patients effectively. General Summary: The Analytical Science and Technology (AS&T) Principal Scientist, Separation Method Expert, will be responsible for providing scientific and technical expertise within and across functional areas for late-stage & commercial methods and vendor management.
Principal Scientist, Protein Production & Engineering Disc Medicine IncPrincipal Scientist, Protein Production & EngineeringMA$166,000–$203,000 / yearPOSITION OVERVIEW: Disc Medicine is seeking a detailed-oriented and experienced protein biochemist who will join our Innovation team as a Principal Scientist/Associate Director reporting to our Senior Director, Protein production and engineering. This individual will lead the discovery, design, production and/or characterization of biologics at various discovery and development stages, effectively communicate project updates and contribute to the company portfolio with meaningful opportunities for professional development.
Senior Principal Scientist, Small Molecule Therapeutics Lila Sciences IncSenior Principal Scientist, Small Molecule TherapeuticsCambridge, MAThe ideal candidate is a highly experienced protein scientist and drug discovery leader who can operate strategically while remaining deeply engaged in experimental design, vendor selection, data interpretation, and cross-functional program execution. Oversee recombinant protein expression and purification efforts across external partners and CROs, including vendor selection, scope definition, protocol review, troubleshooting, quality assessment, and timeline management.
Principal Scientist, Biologics Cell Line Development Asimov IncPrincipal Scientist, Biologics Cell Line DevelopmentBoston, MADon't let this stop you from applying, but it's a plus if you are familiar with any of the following: vector optimization to improve titer and product quality attributes for complex bispecific scaffolds; CLD process optimization; or development of automated high-throughput screening for CLD workflows. Significant effort designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology is also an important part of this role.
Principal Scientist, Biology (Immunology) C4 Therapeutics IncPrincipal Scientist, Biology (Immunology)Watertown, MA$187,632–$207,383 / yearC4T's degrader medicines are designed to harness the body's natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. The base pay range for this position at commencement of employment is expected to be between $187,632.00 and $207,383.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.
Principal Scientist, Pharmacology & Immunology DeepCurePrincipal Scientist, Pharmacology & ImmunologyBoston, MA$170,000–$210,000 / yearIn this role, you will serve as a scientific leader driving early-stage drug discovery programs with a strong emphasis on immunology-driven biology and pharmacology, from target validation through IND-enabling stages. By combining advanced computational platforms with deep biological and chemical expertise, DeepCure aims to deliver differentiated therapeutic candidates faster and more efficiently.
Principal Scientist, Computational Biology Stylus MedicinePrincipal Scientist, Computational BiologyCambridge, MassachusettsThis individual will provide high-resolution efficacy and specificity analysis to advance our pipeline as well as support onboarding of new preclinical assays for regulatory submissions, ensure accuracy of our analysis pipelines and translate our wet lab experiments into computational insights that will enable engineering of our next generation LSRs. Build integrated workflows to annotate and characterize target sites by synthesizing proprietary datasets with large-scale public genomic databases.
Principal Scientist Galois, Inc.Principal ScientistBoston, MAWith clients including NASA, DARPA, AWS, and the DoW, we leverage our cutting-edge research to deliver high assurance solutions and tools that enhance security, reliability, and operational efficiency across sectors including aerospace & defense, healthcare, semiconductors, and fintech. Who We Are: From building digital engineering tools that make space exploration safer to verifying cryptographic libraries that protect some of the world’s most valuable data, Galois develops technology to guarantee the trustworthiness of systems where failure is unacceptable.