Design, troubleshoot, and perform experimental staining and fluorescence or confocal imaging for cultured cells, organoids, and brain tissue from Alzheimer’s disease in vivo models; interpret changes in microglial morphology, engraftment, and disease-associated pathology. Design and optimize in vivo modeling approaches for Alzheimer’s disease, including selection of disease models, experimental groups, controls, time points, and readouts to evaluate microglial engraftment, function, and effects on disease-associated pathology.