Design, direct, and interpret complex studies using relevant human tissues and advanced preclinical systems, which may include primary cells, organotypic cultures, co-culture systems, spatial and single-cell approaches, perturbational biology, and disease-relevant in vivo models. Strong record of applying human tissues, disease-relevant cellular systems, organotypic models, spatial biology, single-cell methods, imaging, omics, functional genomics, or perturbational approaches to define mechanisms.