Principal Full Stack AI Engineer Vertex PharmaceuticalsPrincipal Full Stack AI EngineerBoston, Massachusetts$166,640–$250,000 / yearIn this role you will develop AI agents and the services, APIs, and interfaces around them, andconnect the platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows. Enable AI workflows to interact reliably with core enterprise platforms such as collaboration tools, knowledge systems, workflow tools, and line-of-business applications.
Senior Principal AI Engineer Vertex PharmaceuticalsSenior Principal AI EngineerBoston, MassachusettsIn addition to building out the core platform, this engineer will own the vision and day-to-day operations of a centralized AI Gateway / Control Plane / Control Tower that enables agent monitoring, observability, policy enforcement, governance, and operational controls across AI solutions at Vertex. Demonstrated experience using AI-assisted software development and autonomous coding agents to design, generate, test, review, debug, optimize, and refactor code across complex enterprise systems.
Principal Scientist, Lab Platform Disruptive Technologies Merck & Co IncPrincipal Scientist, Lab Platform Disruptive TechnologiesCambridge, MA$194,100–$305,600 / yearRequired Skills: Antibody Drug Conjugates (ADC), Biodesign, Detail-Oriented, Emerging Technologies, Ethical Compliance, Gene Cloning, Gene Expression Analysis, Immunochemistry, Leadership Engagement, Mass Spectrometry Analysis, Microscopy Techniques, Project Leadership, Protein Engineering, Protein Interactions, Protein Purifications. This individual will identify and translate emerging, literature-supported technologies into scalable internal capabilities, with a focus on multiplying both the scale and speed of quantitative data generation (e.g., binding measurements) to advance therapeutic programs via GenAI/ML-driven discovery and iterative design-make-test cycles.
Principal Product Designer Chegg, Inc.Principal Product DesignerBoston, MassachusettsWe need someone who operates at the intersection of product strategy, design craft, and AI-first delivery: a person who can determine which problems are worth solving, turn that into a plan the team can build, and bring it to life through design, rapid prototyping, and real user testing. Use a variety of techniques (one-on-one user interviews, rapid prototypes built with AI coding tools, and whatever else works) to validate and invalidate a wide breadth of ideas quickly and cheaply.
Principal System Engineer LIMS ModernaTXPrincipal System Engineer LIMSNorwood, MassachusettsRemoteWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. The Candidae will report to and work closely with the Director, Digital LIMS Systems to ensure the implementation of new solutions and improvement of existing systems (LabVantage) for the Moderna Digital Laboratory Systems organization.
Principal Scientist, Process Development (Expression Systems) ModernaTXPrincipal Scientist, Process Development (Expression Systems)Norwood, MassachusettsWe are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. PhD in Molecular Biology, Microbiology, Chemical/Biochemical Engineering, Biotechnology, Synthetic Biology, or a related discipline with 5+ years of relevant industry experience; or MS with 10+ years; or BS with 12+ years of relevant industry experience.
Principal Software Engineer CadencePrincipal Software EngineerBurlington, MA$117,600–$218,400 / yearPlease note that the salary range is a guideline and compensation may vary based on factors such as qualifications, skill level, competencies and work location. BS with a minimum of 8 years of experience OR MS with a minimum of 5 years of experience OR PhD with a minimum of 3 years of experience.
Senior Scientist or Principal Scientist, Targeted Proteomics Kymera TherapeuticsSenior Scientist or Principal Scientist, Targeted ProteomicsWatertown, MA$115,000–$215,000 / yearDomain leadership with cross-functional drug discovery : Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and enabling program advancement through high-impact experimental data. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.
Principal Software Engineer DigitalOceanPrincipal Software EngineerBoston, MARemote$235,200–$294,000 / yearIAM and KMS are the bedrock of trust at DigitalOcean; our services sit in the critical path of every request, authorizing billions of transactions per second with single-digit millisecond latency, and securing the cryptographic material that protects every customer workload on the platform. Evolve Key Management: Design and deliver a robust, multi-tenant KMS, including envelope encryption, customer-managed key patterns, and HSM-backed key material, that gives customers deep, fine-grained control over their data security posture.
Principal Software Engineer, Enterprise Scalability KlaviyoPrincipal Software Engineer, Enterprise ScalabilityBoston, MA$244,000–$366,000 / yearAI‑assisted scale engineering: AI‑driven anomaly detection reduces alert noise while improving signal; generative load testing and copilot runbooks are used in release/readiness checks for the top critical services; time‑to‑isolate regressions drops 20-30%. In addition to base salary, our total compensation package may include participation in the company's annual cash bonus plan, variable compensation (OTE) for sales and customer success roles, equity, sign-on payments, and a comprehensive range of health, welfare, and wellbeing benefits based on eligibility.
Senior Principal Systems Engineer General Dynamics Mission Systems, IncSenior Principal Systems EngineerDedham, MA$192,113–$202,619 / yearAs a Systems Engineer, working with custom software built in-house, for our Cyber group, you’ll be amember of a cross functional team responsible for developing mission critical NSA-certified Cybersecurity devices in a rapidly growing product line. General Dynamics Mission Systems (GDMS) engineers a diverse portfolio of high technology solutions, products and services that enable customers to successfully execute missions across all domains of operation.
Principal Product Manager - Hardware Accelerator Virtualization Red Hat Inc.Principal Product Manager - Hardware Accelerator VirtualizationBoston, MARemote$154,190–$254,380 / yearMust have two (2) years of experience with: Red Hat OpenShift Platform, Red Hat OpenStack Platform, VMware vSphere, or other enterprise-level infrastructure solutions; the Agile development process; overseeing the integration and lifecycle management of hardware enablement components at the kernel-level, driver compatibility, and upgrades; and management frameworks for various types of accelerators. What You Will Bring: Master's degree (U.S. or foreign equivalent) in Mechanical Engineering, Technology Management, Business Administration or related field and five (5) years of experience in the job offered or related role OR Bachelor's degree (U.S. or foreign equivalent) in Mechanical Engineering, Technology Management, Business Administration or related field and seven (7) years of experience in the job offered or related role.
Senior Principal Ae-Rf Design Engineer CadenceSenior Principal Ae-Rf Design EngineerBurlington, MARequires a deep, specialized skill set: Building Blocks: Deep expertise in designing custom blocks such as Power Amplifiers (PAs), Low Noise Amplifiers (LNAs), mixers, and Voltage-Controlled Oscillators (VCOs). Validation: Extensive lab characterization experience utilizing high-frequency equipment like spectrum analyzers, VNAs, and probe stations.
Principal Software Engineer - Compiler Development CadencePrincipal Software Engineer - Compiler DevelopmentBurlington, MA$117,600–$218,400 / yearBy offering Electronic Design Automation (EDA) tools, they enable engineers to simulate, verify, and optimize chip designs for various high-growth industries, including automotive, 5G, and hyperscale computing. Design Scalability: Architect compiler and simulator specifically tuned for complex AI designs, ensuring the engine can handle the massive replicated and parallel structures inherent in next-gen neural processing units (NPUs).
Principal Systems Architect (Ist, North Reading, MA) Teradyne, Inc.Principal Systems Architect (Ist, North Reading, MA)North Reading, MA$166,300–$266,100 / yearThe Teradyne's Integrated Systems Test (IST) Hardware Engineering team is seeking a highly motivated, energetic, technically driven System Engineer to deliver world class System Level Test solutions to our growing portfolio of customers. You will be responsible for interpreting business requirements and developing system requirements and architectures for Teradyne's IST product lines with a focus on new product development, as well as supporting the product line's goals around customer satisfaction, revenue, profitability and KPI's.
Principal Mechanical Engineer / Systems Engineer HaloBraidPrincipal Mechanical Engineer / Systems EngineerCambridge, MassachusettsThis is one of the hardest unsolved problems in robotics, applied to a $270B salon services industry, and integrating computer vision, compliant fiber manipulation, and novel mechanisms. Understand the full HaloBraid machine and its architecture: identify design, tolerance, assembly, serviceability, and dependency issues, and drive them to resolution.
Sr Principal C++ Software Engineer CadenceSr Principal C++ Software EngineerBurlington, MA$140,000–$260,000 / yearThe team brings a unique focus to quality and innovation while designing state-of-the-art Cadence emulation products for use in developing today's multi-billion gate designs. You will work closely with a small team of exceptional engineers that are heavyweights in Cadence and EDA while developing the next generation Palladium emulation platform.
Principal Systems Architect (IST, North Reading, MA) TeradynePrincipal Systems Architect (IST, North Reading, MA)North Reading, MA$166,300–$266,100 / yearThe Teradyne’s Integrated Systems Test (IST) Hardware Engineering team is seeking a highly motivated, energetic, technically driven System Engineer to deliver world class System Level Test solutions to our growing portfolio of customers. You will be responsible for interpreting business requirements and developing system requirements and architectures for Teradyne’s IST product lines with a focus on new product development, as well as supporting the product line’s goals around customer satisfaction, revenue, profitability and KPI’s.
Principal, Fund Controller Partner's CapitalPrincipal, Fund ControllerBoston, MassachusettsStrategic Partnership and Other: You will serve as a trusted advisor to global client CIOs, fund PMs, and research teams, ensuring fund finance considerations are integrated into broader strategic decisions. The Firm designs bespoke investment policies reflecting each client’s unique circumstances and implements investment solutions that aim to deliver strong returns with resilience across market cycles.
NewAssociate Principal Scientist, Clinical Research Merck & Co IncAssociate Principal Scientist, Clinical ResearchBoston, MA$142,400–$224,100 / yearTranslational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Leads and directs teams through key study planning, development, and execution activities, including program overviews, issue escalation and mitigation, senior management presentations, cross-functional governance meetings, and advisory meeting preparation.