For that, we use mouse models, intravital and explant calcium imaging, genetically encoded calcium reporters, quantitative measurements of intestinal physiology, molecular immunology, viral-assisted neural circuit tracing, optogenetics and chemogenetics, CRISPR-Cas9 genetic alterations, single-cell genomics, and diet engineering. One objective of our studies is to develop dietary strategies that use the modulation of gut neurons to combat gastrointestinal-associated diseases, including inflammatory bowel disease, irritable bowel syndrome, gut infections, malabsorption conditions, and metabolic disturbances.