Principal Scientist, Biomarker Assay Development Bench Scientist Novartis AGPrincipal Scientist, Biomarker Assay Development Bench ScientistCambridge, MA$108,500–$201,500 / yearNovartis Biomedical Research is seeking a highly skilled and motivated Principal Scientist (Level 4) to conduct bench research in a laboratory focused on preclinical and clinical biomarker assay development within Disease Area X (DAx). This position is integral to designing, developing, and qualifying biomarker assays that support drug discovery and development programs across DAx's diverse portfolio, including renal, liver, fibrosis, and exploratory indications.
Scientist/Senior Scientist, Viral Vector Analytical Development Obsidian Therapeutics IncScientist/Senior Scientist, Viral Vector Analytical DevelopmentCambridge, MA$130,500–$180,500 / yearThe Scientist/Senior Scientist, Viral Vector Analytical Development is a key role within our Technical Operations group and will serve as both a technical leader and hands-on scientist, contributing to the development, optimization, troubleshooting, transfer, and lifecycle management of analytical methods for viral vectors for our first clinical stage autologous cell therapy program targeting solid tumors. As a member of our Technical Operations team, you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE platform.
Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics Spear Bio IncScientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and BiophysicsWoburn, MATroubleshoot assay-performance issues, including low signal, nonspecific background, limited sensitivity, poor reproducibility, matrix effects, instability, and lot-to-lot variability, using a mechanistic understanding of binding kinetics, affinity, avidity, thermodynamics, steric effects, and molecular interactions. The Scientist / Senior Scientist will design, optimize, and troubleshoot innovative protein-detection assays that integrate antibody-based recognition, nucleic-acid interactions, conjugation chemistry, reaction kinetics, and quantitative analytical methods.
Scientist/Senior Scientist, Assay Development - Neuroscience Biomarkers Spear Bio IncScientist/Senior Scientist, Assay Development - Neuroscience BiomarkersWoburn, MAProvide scientific leadership and translate biomarker biology into assay-design strategies by optimizing for clinically relevant molecular forms, isoforms, post-translational modifications, cleavage fragments, aggregation states, epitopes, and sample types. The successful candidate will help optimize assay strategies, identify the most relevant molecular forms and epitopes, evaluate preanalytical variables and matrix effects, interpret clinical-sample data, and troubleshoot complex assay-development challenges.
Associate Scientist / Scientist I, Computational Test Development PrecedeAssociate Scientist / Scientist I, Computational Test DevelopmentBoston, MassachusettsWe are pioneering an advanced, minimally invasive, comprehensive epigenomics platform with the potential to profoundly impact the research and development of new medicines and the use of approved medicines in clinical practice across a number of conditions, including cancer. MSc in computational biology, bioinformatics, biostatistics, or a closely related quantitative field with 3–4 years of industry or post-graduate research experience in a data-intensive biological or biomedical setting, Ph.
Scientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and Biophysics Spear BioScientist/Senior Scientist, Assay Development - Molecular Assay Chemistry and BiophysicsWoburn, MassachusettsTroubleshoot assay-performance issues, including low signal, nonspecific background, limited sensitivity, poor reproducibility, matrix effects, instability, and lot-to-lot variability, using a mechanistic understanding of binding kinetics, affinity, avidity, thermodynamics, steric effects, and molecular interactions. The Scientist / Senior Scientist will design, optimize, and troubleshoot innovative protein-detection assays that integrate antibody-based recognition, nucleic-acid interactions, conjugation chemistry, reaction kinetics, and quantitative analytical methods.
Scientist/Senior Scientist, Assay Development - Neuroscience Biomarkers Spear BioScientist/Senior Scientist, Assay Development - Neuroscience BiomarkersWoburn, MassachusettsProvide scientific leadership and translate biomarker biology into assay-design strategies by optimizing for clinically relevant molecular forms, isoforms, post-translational modifications, cleavage fragments, aggregation states, epitopes, and sample types. The successful candidate will help optimize assay strategies, identify the most relevant molecular forms and epitopes, evaluate preanalytical variables and matrix effects, interpret clinical-sample data, and troubleshoot complex assay-development challenges.
Data Scientist II / Senior Data Scientist, Life Sciences Lila Sciences IncData Scientist II / Senior Data Scientist, Life SciencesCambridge, MA$140,800–$217,800 / yearFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. This person will turn experimental data into actionable scientific insight, translate bench workflows into validated analytical requirements, and build reproducible analysis patterns that scale across life sciences programs.
Scientist II/Sr. Scientist I, In-Vivo Pharmacology (Must Have Immunology Experience) Antares TherapeuticsScientist II/Sr. Scientist I, In-Vivo Pharmacology (Must Have Immunology Experience)Boston, MassachusettsThe successful candidate will contribute across multiple discovery-stage programs through IND-enabling studies, working closely with cross-functional partners in biology, medicinal chemistry, and DMPK. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job.
Scientist II / Senior ML Scientist, Data-Efficient Learning for Drug Discovery Lila Sciences IncScientist II / Senior ML Scientist, Data-Efficient Learning for Drug DiscoveryCambridge, MA$228,000–$358,000 / yearThis role connects model training with scientific decision-making: data acquisition plans should be useful to computational chemists evaluating compound priorities, computational biophysicists deciding when simulation is warranted, and cofolding modelers deciding which protein-ligand data would improve structure-aware models. You will use and develop approaches across active learning, meta-learning, fine-tuning, uncertainty estimation, experimental design, and multimodal modeling to help Lila build closed-loop systems that learn efficiently from targeted data acquisition.
Data Scientist II / Senior Data Scientist, Life Sciences Lila SciencesData Scientist II / Senior Data Scientist, Life SciencesCambridge, MassachusettsFull-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. This person will turn experimental data into actionable scientific insight, translate bench workflows into validated analytical requirements, and build reproducible analysis patterns that scale across life sciences programs.
NewRaven StealthCo - Scientist/Senior Scientist, Protein Engineering and Discovery Biology RavenRaven StealthCo - Scientist/Senior Scientist, Protein Engineering and Discovery BiologyBoston, MassachusettsThe ideal candidate combines deep knowledge of antibody structure and function with hands-on expertise in cell-based assay development, cell culture, and protein analytics, and is comfortable working at the interface of protein engineering and cell biology. We are building a platform to deliver oligos with high precision to previously untargeted cells, while focused on “undruggable” genes, alone or in combination with previously validated targets.
NewSenior Scientist I/Senior Scientist II, Analytical Sciences Sail BiomedicinesSenior Scientist I/Senior Scientist II, Analytical SciencesCambridge, MA$125,000–$175,000 / yearThis individual will apply strong scientific judgment to solve complex analytical challenges, generate high-quality data, and develop phase-appropriate methods and testing strategies that support preclinical and clinical program advancement. Hands-on experience with multiple analytical techniques, such as chromatography, capillary electrophoresis, UV-Vis spectroscopy, dynamic light scattering, plate-based assays, ligand-binding assays, molecular biology methods, or cell-based assays.
NewSenior Scientist I/Senior Scientist II, Analytical Sciences Senda Biosciences Inc (Inactive)Senior Scientist I/Senior Scientist II, Analytical SciencesCambridge, MA$125,000–$175,000 / yearThis individual will apply strong scientific judgment to solve complex analytical challenges, generate high-quality data, and develop phase-appropriate methods and testing strategies that support preclinical and clinical program advancement. Hands-on experience with multiple analytical techniques, such as chromatography, capillary electrophoresis, UV-Vis spectroscopy, dynamic light scattering, plate-based assays, ligand-binding assays, molecular biology methods, or cell-based assays.
Scientist/Senior Scientist, Viral Vector Analytical Development Obsidian TherapeuticsScientist/Senior Scientist, Viral Vector Analytical DevelopmentCambridge, MA$130,500–$180,500 / yearThe Scientist/Senior Scientist, Viral Vector Analytical Development is a key role within our Technical Operations group and will serve as both a technical leader and hands-on scientist, contributing to the development, optimization, troubleshooting, transfer, and lifecycle management of analytical methods for viral vectors for our first clinical stage autologous cell therapy program targeting solid tumors. As a member of our Technical Operations team, you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE platform.
NewAssociate Scientist/Scientist I, In Vivo Pharmacology Flagship Pioneering, Inc.Associate Scientist/Scientist I, In Vivo PharmacologyCambridge, MA USA$96,000–$126,500 / hourBy combining a large and growing proprietary in vivo biodistribution dataset, machine learning-guided lipid nanoparticle optimization, modular targeted particle design, and integrated translation and manufacturing capabilities, Mirai helps partners accelerate development, reduce technical risk, and pursue high-value programs making delivery a strategic advantage. This role requires greater independence than an entry-level associate position: the Scientist I is expected to design experiments, troubleshoot independently, and contribute to the direction of in vivo studies, while working closely and collaboratively with a cross-functional team.
Senior Scientist II/Principal Scientist, Molecular Cloning Technologies Flagship Pioneering IncSenior Scientist II/Principal Scientist, Molecular Cloning TechnologiesCambridge, MA$143,000–$214,500 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
NewScientist II or Senior Scientist, Protein Analytics Alloy TherapeuticsScientist II or Senior Scientist, Protein AnalyticsWaltham, MAFull timeAlloy’s Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities. Deliver : Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and developability packages that inform key program decisions.
Scientist II Or Senior Scientist, Protein Analytics Alloy TherapeuticsScientist II Or Senior Scientist, Protein AnalyticsWaltham, MA$130,000–$160,000 / yearAlloy's Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities. Deliver: Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and developability packages that inform key program decisions.
Pioneering Medicines: Scientist / Sr. Scientist, Translational Sciences T-cell focused Flagship Pioneering IncPioneering Medicines: Scientist / Sr. Scientist, Translational Sciences T-cell focusedCambridge, MA$100,000–$181,500 / yearFlagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Harnessing the drug development expertise of its team together with the power of Flagship''s multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies.